Browsing by Subject "GABA-AT"

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Homology modeling of human GABA-AT and devise some novel and potent inhibitors via computer-aided drug design techniques

Authors:Al-Obaidi, Anas; Elmezayen, Ammar D; Yelekçi, Kemal
Publisher and Date:(Taylor & Francis Inc, 2020)

Gamma-aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5 '-phosphate (PLP)-dependent enzyme which degrades gamma-aminobutyric (GABA) in the brain. GABA is an important inhibitory neurotransmitter that plays important neurological roles in the brain. Therefore, GABA-AT is an important drug target which regulates the GABA level. Novel and potent drug development to inhibit GABA-AT is still very challenging task. In this study, we aimed to devise novel and potent inhibitors against GABA-AT ...