Şahin, Hatice Bahar

Profile Picture
Name Variants
Şahin, Hatice Bahar
H.,Şahin
H. B. Şahin
Hatice Bahar, Şahin
Sahin, Hatice Bahar
H.,Sahin
H. B. Sahin
Hatice Bahar, Sahin
Şahin, H. Bahar
Job Title
Dr. Öğr. Üyesi
Email Address
Hbahar.sahın@khas.edu.tr
Main Affiliation
Molecular Biology and Genetics
Status
Former Staff
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output

4

Articles

4

Citation Count

0

Supervised Theses

0

Filters

2015 - 20162
Reset filters

Settings

Author: Bozzetti, Maria PiaHas files: true

Scholarly Output Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Article
    Citation - Scopus: 21
    The Drosophila Fragile X Mental Retardation Protein Participates in the Pirna Pathway
    (Company of Biologists Ltd, 2015) Bozzetti, Maria Pia; Şahin, Hatice Bahar; Specchia, Valeria; Cattenoz, Pierre B.; Laneve, Pietro; Geusa, Annamaria; Şahin, H. Bahar; Di Tommaso, Silvia D.; Friscini, Antonella; Massari, Serafina; Diebold, Celine; Giangrande, Angela
    RNA metabolism controls multiple biological processes and a specific class of small RNAs called piRNAs act as genome guardians by silencing the expression of transposons and repetitive sequences in the gonads. Defects in the piRNA pathway affect genome integrity and fertility. The possible implications in physiopathological mechanisms of human diseases have made the piRNA pathway the object of intense investigation and recent work suggests that there is a role for this pathway in somatic processes including synaptic plasticity. The RNA-binding fragile X mental retardation protein (FMRP also known as FMR1) controls translation and its loss triggers the most frequent syndromic form of mental retardation as well as gonadal defects in humans. Here we demonstrate for the first time that germline as well as somatic expression of Drosophila Fmr1 (denoted dFmr1) the Drosophila ortholog of FMRP are necessary in a pathway mediated by piRNAs. Moreover dFmr1 interacts genetically and biochemically with Aubergine an Argonaute protein and a key player in this pathway. Our data provide novel perspectives for understanding the phenotypes observed in Fragile X patients and support the view that piRNAs might be at work in the nervous system. © 2015.
  • Thumbnail Image
    Article
    Citation - WoS: 7
    Citation - Scopus: 8
    Novel Mutants of the Aubergine Gene
    (Taylor & Francis Inc, 2016) Şahin, Hatice Bahar; Karataş, Ömer Faruk; Specchia, Valeria; Di Tommaso, Silvia D.; Diebold, Celine; Bozzetti, Maria Pia; Giangrande, Angela
    Aubergine is an RNA-binding protein of the Piwi clade functioning in germline in the piRNA pathway that silences transposons and repetitive sequences. Several mutations of this gene exist but they mostly result in truncated proteins or correspond to mutations that also affect neighboring genes. We have generated complete aubergine knock-out mutants that do not disrupt the neighboring genes. These novel mutants are characterized by PCR and sequencing. Their nature is confirmed by female sterility and by the presence of crystals in testes common to the aubergine loss of function mutations. These mutants provide novel and more appropriate tools for the study of the piRNA pathway that controls genome stability.