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Now showing items 1951-1970 of 4497
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In Between Two Screens: Trauma, Memory, and Subjectivity in Gulsun Karamustafa's Work
(Routledge Journals, Taylor & Francis Ltd, 2023)Informed by psychoanalytic theory, this essay analyses two major video installations, namely The Settler (2003) and Memory of a Square (2005) by Gulsun Karamustafa, who is one of the best-known artists from Turkey. These ... -
In Focus: Non-Western Historiography? Introduction
(Univ Texas Press, 2010)[Abstract Not Available] -
In search of a comprehensive approach to improve civil-military cooperation: The cases of IFOR, SFOR, KFOR and ISAF
(Kadir Has Üniversitesi, 2020)1990'lı yılların başlarından itibaren Yugoslavya'nın dağılması sürecinde yaşanan savaş ve müteakiben önce Bosna-Hersek ve daha sonra Kosova'da icra edilen Barış Harekâtları sivil ve asker oluşumların harekât alanında daha ... -
In silico design and modeling of coumarin derivatives as selective monoamine oxidase a inhibitors
(Kadir Has Üniversitesi, 2014)Selective and reversible inhibition of Monoamine Oxidase (MAO) isoenzymes has an important place in treatment of various neurological disorders. Out of the two isoforms of Monoamine Oxidase enzymes inhibition of MAO-A have ... -
In silico design and modeling of peptidomimetic drug candidates for methionine aminopeptidase 2 enzyme for prevention of cancer
(Kadir Has Üniversitesi, 2019)Birçok hastalık bir araya gelerek kanseri oluşturur. Kanser hücreleri kontrolsüz bir şekilde bölünür. Kanserde hücre çoğalması anormaldir. Yıllar içinde 200'den fazla kanser çeşidi teşhis edilmiştir. Bazı faktörler kansere ... -
In silico design of novel and highly selective cyclooxygenase-2 inhibitors
(Kadir Has Üniversitesi, 2014)For many years, prevention of inflammation is achieved by inhibition of both cyclooxygenase (COX) enzymes; the eventual outcome is gastrointestinal toxicity. Selective inhibitor design for COX-2 initialized just after ... -
In silico design of novel and highly selective lysine-specific histone demethylase inhibitors
(Scientific Technical Research Council Turkey-Tubitak, 2011)Histone lysine-specific demethylase (LSD1) is involved in a wide range of epigenetic processes and plays important roles in gene silencing DNA transcription DNA replication DNA repair and heterochromatin formation. Its ... -
In silico design of selective monoamine Oxidase B inhibitors using indane ring
(Kadir Has Üniversitesi, 2013)in the present work 209952 analogs of an indane scaffold were created using various fragment moieties at different position of indane ring. CHEMPLP module of GOLD program is utilized in the screening process. in order to ... -
In silico design of selective neuronal nitric oxide synthase inhibitors in order to prevent neurodegenerative diseases
(Kadir Has Üniversitesi, 2013)Nitric Oxide syntheses (NOS) are the family of enzymes which catalyzes the oxidation L-Arginine amino acid to nitric oxide molecule (NO) L-citrulline. Mammals contain three different NOS isozymes: Neuronal NOS (nNOS, in ... -
In silico designing of isoform-selective inhibitors against class IIA histone deacetylases
(Kadir Has Üniversitesi, 2021)The fundamental cause of human cancer is strongly influenced by down- or upregulations of epigenetic factors. Upregulated histone deacetylases (HDAC) have been shown to be effectively neutralized by the action of HDACs ... -
In silico identification of critical proteins associated with learning process and immune system for Down syndrome
(Public Library Science, 2019)Understanding expression levels of proteins and their interactions is a key factor to diagnose and explain the Down syndrome which can be considered as the most prevalent reason of intellectual disability in human beings. ... -
In silico identification of novel and selective monoamine oxidase B inhibitors
(SPRINGER WIEN, 2013)Monoamine oxidases (MAO) A and B are flavin adenine dinucleotides containing enzymes bound to the mitochondrial outer membranes of the cells of the brain liver intestine and placenta as well as platelets. Recently selective ... -
In silico identification of physiological substrates and inhibitors of serum paraoxonase 1 enzyme
(Kadir Has Üniversitesi, 2014)Paraoxonase 1 (PON1) as an important antioxidant enzyme against oxidative stress has been implicated in the pathogenesis of a number of disorders including cancer cardiovascular and several other diseases. Although there ... -
In Silico Inhibitor Design For Monomine Oxidase A And B Isozymes
(Kadir Has Üniversitesi, 2012)in this thesis study MAO-A and MAO-B isozymes are selected as target enzymes that have important role of regulation of diseases such as ..Parkinson Alzheimer and depression... MAO isozymes which catalyze the oxidation of ... -
In silico investigation of wound healing potential of some compounds in tubers of Asphodelus species with GSK3-? protein
(Marmara Univ, 2021)Wound healing is a process that involves biochemical processes such as inflammation and cell proliferation and is controlled by many proteins. It is known that one of the most effective factors in this process is the ... -
In Silico Modeling of Dopamine Transporter and Design of Novel Neuroprotective Agents
(Amer Chemical Soc, 2016)[Abstract Not Available] -
In silico modeling of dopamine transporter and design of novel neuroprotective drugs for Parkinson's disease
(Kadir Has Üniversitesi, 2017)Parkinson hastalıgı (PH), substantia nigra (SN) ve corpus striatum (CS) bolgelerinde dopamin ureten noronların kaybedilmesi ile karakterize edilen bir olgudur. Yaygın olarak uygulanan tedavi dopamin noronlarının kaybolmalarının ... -
In silico screening of multi target drug for alzheimer'sdisease and parkinson's disease using pharmacophore-baseddrug discovery approach
(Kadir Has Üniversitesi, 2019)Research on neurodegenerative diseases (NDD), commonly known as Alzheimer's and Parkinson's disease are the most important concern in this aging society. Among the other causes the main suspected reasons are the production ... -
In silico screening of neuronal nitric oxide synthase enzyme inhibitors
(Kadir Has Üniversitesi, 2014)Three closely related isoforms of nitric oxide synthases (NOS) catalyze an important secondary messenger nitric oxide (NO) synthesis through oxidation of L-arginine to L-citrulline. These three NOS isoforms takes parts in ... -
In silico screening of potent histon demethylase1 (lsd1) enzyme inhibitor
(Kadir Has Üniversitesi, 2020)Histone lysine specific demethylase (LSD1) is one of the main enzymes which regulates histone demethylation which in return regulates different epigenetic processes such DNA replication and transcription also gene silencing. ...
