Browsing by Author "Ayyıldız, Merve"
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Identification of Alternative Allosteric Sites in Glycolytic Enzymes for Potential Use as Species-Specific Drug Targets
Ayyıldız, Merve; Çeliker, Serkan; Özhelvacı, Fatih; Akten, Ebru Demet (Frontiers Media, 2020)Three allosteric glycolytic enzymes, phosphofructokinase, glyceraldehyde-3 phosphate dehydrogenase and pyruvate kinase, associated with bacterial, parasitic and human species, were explored to identify potential allosteric ... -
Identification of species-specific allosteric binding sites in phosphofructokinase for drug design studies
Ayyıldız, Merve (Kadir Has Üniversitesi, 2020)Glikolitik yolaktaki en kritik enzimlerden biri olan fosfofruktokinaz (PFK), türe özgü ilaç tasarım çalışmalarında kullanılmak üzere hedeflenmiş ve bakteri, parazit ve insan olmak üzere üç türdeki allosterik bağlanma ...