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Homology modeling andin silicodesign of novel and potential dual-acting inhibitors of human histone deacetylases HDAC5 and HDAC9 isozymes
(2020)
Histone deacetylases (HDACs) are a group of enzymes that have prominent and crucial effect on various biological systems, mainly by their suppressive effect on transcription. Searching for inhibitors targeting their ...
The WS(2)dependence on the elasticity and optical band gap energies of swollen PAAm composites
(Sage Publications, 2020)
New generation nano-filler polymer composites have many applications including biomedical, electronic and maritime related applications because of their mechanical, electronic and optical properties. The properties of ...
Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (Type II)
(Bentham Science PUBL LTD, 2020)
Background: Prostate cancer is still one of the serious causes of mortality and morbidity in men. Despite recent advances in anticancer therapy, there is a still need of novel agents with more efficacy and specificity in ...
Network dynamics reconstruction from data
(Scıentıfıc Technıcal Research Councıl Turkey-Tubıtak, 2020)
We consider the problem of recovering the model of a complex network of interacting dynamical units from time series of observations. We focus on typical networks which exhibit heterogeneous degrees, i.e. where the number ...
Surfactant-free one-step fabrication of gelatin/PAAm/MWCNT composites for biomedical applications
(Springer, 2021)
Well-dispersed multiwalled carbon nanotube (MWCNT) and gelatin-enhanced polyacrylamide (PAAm) composites were synthesized via a free-radical copolymerization method. MWCNTs were added to the composite mixture in various ...
Post-synthetically elaborated BODIPY-based porous organic polymers (POPs) for the photochemical detoxification of a sulfur mustard simulant
(American Chemical Society, 2020)
Designing new materials for the effective detoxification of chemical warfare agents (CWAs) is of current interest given the recent use of CWAs. Although halogenated borondipyrromethene derivatives (4,4-difluoro-4-bora-3a ...
Evaluation of the fractal dimension of polyacrylamide during gelation and swelling
(Elsevier, 2021)
[Abstract Not Available]
Crystallographic structure versus homology model: a case study of molecular dynamics simulation of human and zebrafish histone deacetylase 10
(Taylor & Francis, 2020)
Histone deacetylase (HDAC) 10 has been implicated in the pathology of various cancers and neurodegenerative disorders, making the discovery of novel inhibitors of the isoform an important endeavor. However, the unavailability ...
Holocene climate forcings and lacustrine regime shifts in the Indian summer monsoon realm
(Wıley, 2020)
Extreme climate events have been identified both in meteorological and long-term proxy records from the Indian summer monsoon (ISM) realm. However, the potential of palaeoclimate data for understanding mechanisms triggering ...
Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives
(Elsevier Masson s.r.l., 2020)
In this study, (S)-naproxen thiosemicarbazides (3a-d), 1,2,4-triazoles (4a-c), triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d, 4a and 5a-p) were confirmed by FT-IR, 1H NMR,13C ...