Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed by Institution Author "Yelekçi, Kemal"
Now showing items 21-40 of 52
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Histone Deacetylase Inhibition Activity and Molecular Docking of (E )-Resveratrol: Its Therapeutic Potential in Spinal Muscular Atrophy
Dayangac-Erden, Didem; Bora, Gamze; Ayhan, Peruze; Kocaefe, Çetin; Dalkara, Sevim; Yelekçi, Kemal; Demir, Ayhan S.; Erdem-Yurter, Hayat (Wiley, 2009)Spinal muscular atrophy is an autosomal recessive motor neuron disease that is caused by mutation of the survival motor neuron gene (SMN1) but all patients retain a nearly identical copy SMN2. The disease severity correlates ... -
Homology modeling andin silicodesign of novel and potential dual-acting inhibitors of human histone deacetylases HDAC5 and HDAC9 isozymes
Elmezayen, Ammar D.; Yelekçi, Kemal (2020)Histone deacetylases (HDACs) are a group of enzymes that have prominent and crucial effect on various biological systems, mainly by their suppressive effect on transcription. Searching for inhibitors targeting their ... -
Homology modeling of human GABA-AT and devise some novel and potent inhibitors via computer-aided drug design techniques
Al-Obaidi, Anas; Elmezayen, Ammar D; Yelekçi, Kemal (Taylor & Francis Inc, 2020)Gamma-aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5 '-phosphate (PLP)-dependent enzyme which degrades gamma-aminobutyric (GABA) in the brain. GABA is an important inhibitory neurotransmitter that plays ... -
Homology modeling of human histone deacetylase 10 and design of potential selective inhibitors
Uba, Abdullahi Ibrahim; Yelekçi, Kemal (Taylor & Francis Inc, 2019)Histone deacetylases (HDACs) are implicated in the pathology of various cancers, and their pharmacological blockade has proven to be promising in reversing the malignant phenotypes. However, lack of crystal structures of ... -
Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities
Djikic, Teodora; Marti, Yasmina; Spyrakis, Francesca; Lau, Thorsten; Benedetti, Paolo; Davey, Gavin; Schloss, Patrick; Yelekçi, Kemal (Taylor & Francis Inc, 2019)Parkinson's disease (PD) is characterized by the loss of dopamine-generating neurons in the substantia nigra and corpus striatum. Current treatments alleviate PD symptoms rather than exerting neuroprotective effect on ... -
Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and molecular dynamics studies
Weako, Jackson; Uba, Abdullahi Ibrahim; Keskin, Özlem; Gürsoy, Attila; Yelekçi, Kemal (Elsevier, 2020)Methionine Aminopeptidases MetAPs are divalent-cofactor dependent enzymes that are responsible for the cleavage of the initiator Methionine from the nascent polypeptides. MetAPs are classified into two isoforms: namely, ... -
Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening ADMET prediction and molecular dynamics simulation assay
Uba, Abdullahi İbrahim; Yelekçi, Kemal (Taylor & Francis Inc, 2018)Histone deacetylases (HDACs) have gained increased attention as targets for anticancer drug design and development. HDAC inhibitors have proven to be effective for reversing the malignant phenotype in HDAC-dependent cancer ... -
In silico design of novel and highly selective lysine-specific histone demethylase inhibitors
Akdoğan, Ebru Demet; Erman, Burak; Yelekçi, Kemal (Scientific Technical Research Council Turkey-Tubitak, 2011)Histone lysine-specific demethylase (LSD1) is involved in a wide range of epigenetic processes and plays important roles in gene silencing DNA transcription DNA replication DNA repair and heterochromatin formation. Its ... -
In silico identification of novel and selective monoamine oxidase B inhibitors
Yelekçi, Kemal; Büyüktürk, Bora; Kayrak, Nurdan (SPRINGER WIEN, 2013)Monoamine oxidases (MAO) A and B are flavin adenine dinucleotides containing enzymes bound to the mitochondrial outer membranes of the cells of the brain liver intestine and placenta as well as platelets. Recently selective ... -
Insights into the binding mode of new N-substituted pyrazoline derivatives to MAO-A: docking and quantum chemical calculations
Erdem, Safiye Sag; Turkkan, Seyhan; Yelekçi, Kemal; Gokhan-Kelekçi, Nesrin (SPRINGER WIEN, 2013)The binding modes of four N-substituted pyrazoline derivatives as novel MAO-A inhibitory agents were investigated using docking and quantum chemical molecular modelling tools. -
Intermolecular interactions in human HDAC8 crystal structures and the stability of binding modes of co-crystallized inhibitors
Yelekçi, Kemal; Uba, Abdullahi Ibrahim (Amer Chemical Soc, 2019)[Abstract Not Available] -
MEDI 333-Histone deacetylase inhibition activity of resveratrol and its analogs
Dayangac-Erden, Didem; Ayhan, Peruze; Bora, Gamze; Yelekçi, Kemal; Dalkara, Sevim; Demir, Ayhan S.; Erdem-Yurter, Hayat (Amer Chemical Soc, 2007)[Abstract Not Available] -
Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies
Bora-Tatar, Gamze; Dayangac-Erden, Didem; Demir, Ayhan S.; Dalkara, Sevim; Yelekçi, Kemal; Erdem-Yurter, Hayat (Pergamon-Elsevier Science Ltd, 2009)In the light of known HDAC inhibitors 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop the structure-activity ... -
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors
Salgın-Göksen, Umut; Telli, Gökçen; Erikci, Açelya; Dedecengiz, Ezgi; Tel, Banu Cahide; Kaynak, F. Betül; Yelekçi, Kemal; Ücar, Gülberk; Gökhan-Kelekçi, Nesrin (AMER CHEMICAL SOC, 2021-02)Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazoline structure and nine compounds having N'-(1,3-disubstitutedphenylallylidene)-2-(5-substituted- 2-benzoxazolin ... -
New Human Monoamine Oxidase A Inhibitors with Potential Anti- Depressant Activity: Design, Synthesis, Biological Screening and Evaluation of Pharmacological Activity
Evranos Aksöz, Begüm; Uçar, Gülberk; Taş, Sadık Taşkın; Aksöz, Erkan; Yelekçi, Kemal; Erikçi, Açelya; Sara, Yıldırım; İskit, Alper Bektaş (Bentham Science, 2017)Aim and objective: Depression is a momentous disease that can greatly reduce the quality of life and cause death. In depression, neurotransmitter levels such as serotonine, dopamine and noradrenaline are impaired. Monoamine ... -
Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6
Uba, Abdullahi Ibrahim; Yelekçi, Kemal (Elsevier Sci Ltd, 2018)Histone deacetylase (HDAC) 6 plays a role in oncogenic transformation and cancer metastasis via tubulin deacetylation, making it a critical target for anticancer drug design. However, lack of selectivity shown by many of ... -
Potential inhibitors of methionine aminopeptidase type II identified via structure-based pharmacophore modeling
Albayati, Safana; Uba, Abdullahi İbrahim; Yelekçi, Kemal (Springer Science and Business Media Deutschland GmbH, 2021)Methionine aminopeptidase (MetAP2) is a metal-containing enzyme that removes initiator methionine from the N-terminus of a newly synthesized protein. Inhibition of the enzyme is crucial in diminishing cancer growth and ... -
Power of inhibition activity screening and 3D molecular modeling approaches in HDAC 8 inhibitor design
Tatar, Gamze Bora; Tokluman, Tenzile Deniz; Yelekçi, Kemal; Yurter, Hayat (Scientific Technical Research Council Turkey-Tubitak, 2011)In-vitro inhibition activity screening and in-silico 3D molecular modeling approaches are important tools for design and development of specific histone deacetylase (HDAC) inhibitors. The objective of this study was to ... -
Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors
Gökhan-Kelekçi, Nesrin; Şimşek, O. Özgün; Ercan, Ayşe; Yelekçi, Kemal; Şahin, Z. Sibel; Işık, Şamil; Uçar, Gülberk; Bilgin, Abdullah Altan (Pergamon-Elsevier Science Ltd, 2009)A novel series of 2-thiocarbamoyl-234567-hexahydro-1H-indazole and 2-substituted thiocarbamoyl-33a 4567-hexahydro-2H-indazoles derivatives were synthesized and investigated for the ability to inhibit the activity of the A ... -
Synthesis and screening of hMAO inhibitory activities of some new 2-pyrazoline and hydrazone derivatives
Evranos-Aksoz, Begum; Yabanoglu-Ciftci, Samiye; Ucar, Gulberk; Yelekçi, Kemal; Ertan, Rahmiye (Wiley-Blackwell, 2014)[Abstract Not Available]