Browsing Scopus İndeksli Yayınlar Koleksiyonu by Author "Akdoğan, Ebru Demet"
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Exploring distinct binding site regions of beta(2)-adrenergic receptor via coarse-grained molecular dynamics simulations
Cakan, Sibel; Akdoğan, Ebru Demet (Scientific Technical Research Council Turkey-Tubitak, 2013)beta(2)-Adrenergic receptor (beta(2)AR) is a G protein-coupled receptor that is highly flexible and able to recognize a wide range of ligands through its conformational variations. Active and inactive conformations revealed ... -
How an Inhibitor Bound to Subunit Interface Alters Triosephosphate Isomerase Dynamics
Kürkçüoğlu, Zeynep; Fındık, Doğa; Akdoğan, Ebru Demet; Doruker, Pemra (Cell Press, 2015)The tunnel region at triosephosphate isomerase (TIM)'s dimer interface distant from its catalytic site is a target site for certain benzothiazole derivatives that inhibit TIM's catalytic activity in Trypanosoma cruzi the ... -
In silico design of novel and highly selective lysine-specific histone demethylase inhibitors
Akdoğan, Ebru Demet; Erman, Burak; Yelekçi, Kemal (Scientific Technical Research Council Turkey-Tubitak, 2011)Histone lysine-specific demethylase (LSD1) is involved in a wide range of epigenetic processes and plays important roles in gene silencing DNA transcription DNA replication DNA repair and heterochromatin formation. Its ...