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Now showing items 81-90 of 113
New azole derivatives showing antimicrobial effects and their mechanism of antifungal activity by molecular modeling studies
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)
Azole antifungals are potent inhibitors of fungal lanosterol 14 alpha demethylase (CYP51) and have been used for eradication of systemic candidiasis clinically. Herein we report the design synthesis and biological evaluation ...
Assessing protein-ligand binding modes with computational tools: the case of PDE4B
(Springer, 2017)
In a first step in the discovery of novel potent inhibitor structures for the PDE4B family with limited side effects we present a protocol to rank newly designed molecules through the estimation of their IC values. Our ...
Surfactant and Metal Ion Effects on the Mechanical Properties of Alginate Hydrogels
(Elsevier Science Bv, 2016)
This paper addresses the controlled variation of the mechanical properties of alginate gel beads by changing the alginate concentration or by adding different surfactants or cross-linking cations. Alginate beads containing ...
Investigation of Allosteric Coupling in Human Beta(2)-Adrenergic Receptor in the Presence of Intracellular Loop 3
(BMC, 2016)
Background: This study investigates the allosteric coupling that exists between the intra- and extracellular parts of human beta(2)-adrenergic receptor (beta(2)-AR) in the presence of the intracellular loop 3 (ICL3) which ...
The Electrochromic Performances of Single Phase VO2 Nanoparticled Films
(Elsevier Science SA, 2016)
In the present work pure phase vanadium oxide VO2 nanoparticled films were synthesized using acetate based sol-gel precursors. The effect of the water: Vanadyl acetylacetonate ratio on electrochemical and structural ...
Determination of growth kinetics and size dependent structural morphological optical characteristics of sol-gel derived silica nanoparticles in silica matrix
(De Gruyter Poland Sp Zoo, 2019)
Nanocomposite silica thin films made using the sol-gel method were studied. The nano-silica films were prepared using a mixture of tetraethyl orthosilicate (TEOS) deionized water ethanol and ammonia solution. To control ...
Universality in gelation of epoxy acrylate with various photoinitiators: a photo differential scanning calorimetric study
(Taylor & Francis Ltd, 2008)
Photo-differential scanning calorimetric (Photo-DSC) technique was used to study the gelation of P-3038 (epoxy acrylate (EA) 75% and tripropyleneglycoldiacrylate (TPGDA) 25%) in the presence of various thioxanthone-based ...
Thermal rearrangement of 2-acetoxy-266-trimethylbicyclo[3.1.0]hexane: Theoretical elucidation of the mechanism
(Elsevier Science, 2007)
Bicyclohexenes are believed to be the immediate precursors of aromatic compounds. As a part of the exploratory study of thermal aromatization reactions 266-trimethylbicyclo[3.1.0]hexan-2-ol and its ester derivative ...
The Drosophila fragile X mental retardation protein participates in the piRNA pathway
(Company of Biologists Ltd, 2015)
RNA metabolism controls multiple biological processes and a specific class of small RNAs called piRNAs act as genome guardians by silencing the expression of transposons and repetitive sequences in the gonads. Defects in ...
Exploring distinct binding site regions of beta(2)-adrenergic receptor via coarse-grained molecular dynamics simulations
(Scientific Technical Research Council Turkey-Tubitak, 2013)
beta(2)-Adrenergic receptor (beta(2)AR) is a G protein-coupled receptor that is highly flexible and able to recognize a wide range of ligands through its conformational variations. Active and inactive conformations revealed ...