Browsing Tez Koleksiyonu by Author "Yelekçi, Kemal"
Now showing items 21-25 of 25
-
De novo selective inhibitor design to neuronal NOS enzyme and exploration of the binding site
Büyüktürk, Bora (Kadir Has Üniversitesi, 2013)Neural Nitric Oxide Synthase (nNOS) is an enzyme that plays a significant role in neural signal transmission among brain cells by carrying on Nitric Oxide(NO) generation. nNOS is one of the member of Nitric Oxide Synthase ... -
Potent inhibitors designed for methionine aminopeptidase II using pharmocophore modeling /
Bayatı, Safanah A. Al; Yelekçi, Kemal (Kadir Has Üniversitesi, 2019)Metaloenzimlerden Metiyonin Aminopeptidazlar (MetAP2), yeni sentezlenmiş polipep-titlerin başından metionin amino asidini kesmekle sorumludur. MetAP2'nin seçimli olarak engellenmesi damar oluşumunu baskıladığını, katı ... -
Repurposing of existing drugs for treatment of Covid-19 target RNA-dependent RNA polymerase (RdRp) enzyme-using in silico screening techniques
Kiliç, Meltem (Kadir Has Üniversitesi, 2021)Korona virüsü 2019'dan bu yana dünya genelinde 5 milyondan fazla insanın hayatını kaybetmesine neden olan hastalıktır. 2020 yılında dünya sağlık örgütü tarafından pandemi oluşturan hastalıklar arasına adını yazdıran korona ... -
Structure Prediction of TB RPOB and its Mutations Binding Analysis
Dinçer, Erçin (Kadir Has Üniversitesi, 2012)--Today Tuberculosis is a disease that is still a high-risk categories. Rifampicin is a drug that.s used common in the treatment of TB. We know that the effect of this drug in the region of RNA polymerase on TB. Unfortunately ... -
Targeting cancer epigenetic modifiers: The design of isoform-selective histone deacetylase inhibitors
Uba, Abdullahi İbrahim (Kadir Has Üniversitesi, 2018)Epigenetic alterations are believed to be the common hallmark of human cancers. Histone deacetylase (HDAC) inhibitors have proven to be effective in cancer cases where HDACs are up-regulated. However lack of selectivity ...