Browsing Tez Koleksiyonu by Author "Yelekçi, Kemal"
Now showing items 1-20 of 25
-
Augmented virtual crossmatch for donor-induced antibody prediction by using high resolution human leukocyte antigen typing and human leukocyte antigen epitope mapping for better donor match
Karadeniz, Sedat Tanju (Kadir Has Üniversitesi, 2023-01)The Human Leukocyte Antigen (HLA) disparity between donors and recipients is the primary driver of Donor Specific Antibodies (DSA) formation and graft rejection after transplantation. We aimed to predict the DSA by finding ... -
Corrected PRA positivity rates for hypersensitized patients in Turkish population with calculated PRA-cPRA software
Karadeniz, Sedat Tanju (Kadir Has Üniversitesi, 2017)Yüksek PRA (Panel Reaktif Antikor) oranları, böbrek nakli şansını düşürebilir ve nakilden önce uzun süre beklemeye yol açabilir. cPRA (Hesaplamalı Panel Reaktif Antikor), kabul edilemez (uyumsuz) HLA (Human Lökosit Antijen) ... -
Design of novel and potent inhibitors for mPGES-1 enzyme via in silico screening
Çiftçi, Gamze (Kadir Has Üniversitesi, 2021)To prevent inflammation in the body, non-steroidal anti-inflammatory drugs act by suppressing PGE2 production as a result of non-selective inhibition of both COX-1 and COX-2 enzymes. As a result of the inhibition of COX-1 ... -
Designing inhibitors via molecular modelling methods for monoamine oxidase isozymes a and b
Varnalı, Filiz (Kadir Has Üniversitesi, 2012)in drug development studies a large number of new drug candidates (leads)have to be synthesized and optimized by changing several moieties of the leads in order to increase efficacies and decrease toxicities. Each synthesis ... -
Designing of selective and potent inhibitors against histone deacetylase enzymes (HDAC6 VE HDAC10) via in silico screening and molecular modeling techniques for the treatment of cancer
Mert, Naz Mina (Kadir Has Üniversitesi, 2021)HDACs are the class of enzymes that are involved in the process of cancer development by removing the acetyl groups from histone protein, inducing chromatin condensation and in this way regulating the expression of tumor ... -
Docking study of resveratrol like molecules on histone deacetylase
Alnemsi, Fatma (Kadir Has Üniversitesi, 2016)The modulation of histone acetylation plays a pivotal role in the regulation of gene expression by governing the state of lysine residues located on the amino – terminal tails of histone proteins. A dynamic balance of ... -
In silico design and modeling of coumarin derivatives as selective monoamine oxidase a inhibitors
Karaman, Dilara (Kadir Has Üniversitesi, 2014)Selective and reversible inhibition of Monoamine Oxidase (MAO) isoenzymes has an important place in treatment of various neurological disorders. Out of the two isoforms of Monoamine Oxidase enzymes inhibition of MAO-A have ... -
In silico design of novel and highly selective cyclooxygenase-2 inhibitors
Mehmetoğlu, Tuğba (Kadir Has Üniversitesi, 2014)For many years, prevention of inflammation is achieved by inhibition of both cyclooxygenase (COX) enzymes; the eventual outcome is gastrointestinal toxicity. Selective inhibitor design for COX-2 initialized just after ... -
In silico design of selective monoamine Oxidase B inhibitors using indane ring
Altuntas, Serkan (Kadir Has Üniversitesi, 2013)in the present work 209952 analogs of an indane scaffold were created using various fragment moieties at different position of indane ring. CHEMPLP module of GOLD program is utilized in the screening process. in order to ... -
In silico design of selective neuronal nitric oxide synthase inhibitors in order to prevent neurodegenerative diseases
Kayrak, Nurdan (Kadir Has Üniversitesi, 2013)Nitric Oxide syntheses (NOS) are the family of enzymes which catalyzes the oxidation L-Arginine amino acid to nitric oxide molecule (NO) L-citrulline. Mammals contain three different NOS isozymes: Neuronal NOS (nNOS, in ... -
In silico designing of isoform-selective inhibitors against class IIA histone deacetylases
Elmezayen, Ammar Dawoud Ahmed Mahmoud (Kadir Has Üniversitesi, 2021)The fundamental cause of human cancer is strongly influenced by down- or upregulations of epigenetic factors. Upregulated histone deacetylases (HDAC) have been shown to be effectively neutralized by the action of HDACs ... -
In silico identification of physiological substrates and inhibitors of serum paraoxonase 1 enzyme
Karabıyık, Talha (Kadir Has Üniversitesi, 2014)Paraoxonase 1 (PON1) as an important antioxidant enzyme against oxidative stress has been implicated in the pathogenesis of a number of disorders including cancer cardiovascular and several other diseases. Although there ... -
In Silico Inhibitor Design For Monomine Oxidase A And B Isozymes
Mıdık, Çağla (Kadir Has Üniversitesi, 2012)in this thesis study MAO-A and MAO-B isozymes are selected as target enzymes that have important role of regulation of diseases such as ..Parkinson Alzheimer and depression... MAO isozymes which catalyze the oxidation of ... -
In silico modeling of dopamine transporter and design of novel neuroprotective drugs for Parkinson's disease
Dikic, Teodora (Kadir Has Üniversitesi, 2017)Parkinson hastalıgı (PH), substantia nigra (SN) ve corpus striatum (CS) bolgelerinde dopamin ureten noronların kaybedilmesi ile karakterize edilen bir olgudur. Yaygın olarak uygulanan tedavi dopamin noronlarının kaybolmalarının ... -
In silico screening of multi target drug for alzheimer'sdisease and parkinson's disease using pharmacophore-baseddrug discovery approach
Raji, Sarah Mohammed Jaafar (Kadir Has Üniversitesi, 2019)Research on neurodegenerative diseases (NDD), commonly known as Alzheimer's and Parkinson's disease are the most important concern in this aging society. Among the other causes the main suspected reasons are the production ... -
In silico screening of neuronal nitric oxide synthase enzyme inhibitors
Örtmen, Bahanur (Kadir Has Üniversitesi, 2014)Three closely related isoforms of nitric oxide synthases (NOS) catalyze an important secondary messenger nitric oxide (NO) synthesis through oxidation of L-arginine to L-citrulline. These three NOS isoforms takes parts in ... -
In silico screening of potent histon demethylase1 (lsd1) enzyme inhibitor
TAHER AL-RIKABI, MARYAM MUHSIN (Kadir Has Üniversitesi, 2020)Histone lysine specific demethylase (LSD1) is one of the main enzymes which regulates histone demethylation which in return regulates different epigenetic processes such DNA replication and transcription also gene silencing. ... -
In silico screening of potent HIV-1 integrase inhibitors for the treatment of human immunodeficiency virus (HIV)
Samorlu, Augustine (Kadir Has Üniversitesi, 2018)Bu araştırmanın amacı, AIDS olarak bilinen insan bağışıklık sistemine etki eden, duraksamayan ve depresif bir hastalığa neden olan HIV-1'in tedavisi için potansiyel inhibitörleri elde etmektir. HIV-1 integraz inhibitörleri, ... -
In silico screening of potential peroxisome proliferator-activated receptors (Alpha-gamma) ppars ?/? for the treatment of human diabetic mellitus (DM)
ABDULJABBAR, Farah Ismael (Kadir Has Üniversitesi, 2020)Diabetes mellitus (DM) means a metabolic ailment identified by hyperglycemia, obesity, hypertension, which can contribute to the metabolic disturbances on sugars, lipids, and protein. PPARα and PPARγ become signified the ... -
In silico screening of tangible-potential inhibitor of methionine aminopeptidase 2 for the treatment of cancer
Weako, Jackson (Kadir Has Üniversitesi, 2017)Methionine Aminopeptidases (MetAPs) are divalent-cofactor dependent enzymes that are responsible for cleaving the initiator Methionine from the newly synthesized polypeptides. These metalloproteases are classified into two ...