Browsing Mühendislik ve Doğa Bilimleri Fakültesi by Author "Bora-Tatar, Gamze"
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Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies
Bora-Tatar, Gamze; Dayangac-Erden, Didem; Demir, Ayhan S.; Dalkara, Sevim; Yelekçi, Kemal; Erdem-Yurter, Hayat (Pergamon-Elsevier Science Ltd, 2009)In the light of known HDAC inhibitors 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop the structure-activity ...