Browsing WoS İndeksli Yayınlar Koleksiyonu by Author "Uba, Abdullahi Ibrahim"
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Antioxidant and Enzyme Inhibitory Properties, and HPLC-MS/MS Profiles of Different Extracts of Arabis carduchorum Boiss.: An Endemic Plant to Turkey
Uba, Abdullahi Ibrahim; Zengin, Gokhan; Montesano, Domenico; Cakilcioglu, Ugur; Selvi, Selami; Ulusan, Musa Denizhan; Caprioli, Giovanni (Mdpi, 2022)In this study, six extracts of Arabis carduchorum prepared from solvents of varying polarity (water, methanol, ethyl acetate, dichloromethane, and n-hexane) were investigated for their chemical profiles and total phenolic ... -
Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves
Swiatek, Lukasz; Sieniawska, Elwira; Sinan, Kouadio Ibrahime; Zengin, Gokhan; Uba, Abdullahi Ibrahim; Bene, Kouadio; Maciejewska-Turska, Magdalena (Mdpi, 2022)Spathodea campanulata is an important medicinal plant with traditional uses in the tropical zone. In the current work, we aimed to determine the chemical profiles and biological effects of extracts (methanolic and infusion ... -
Carboxylic acid derivatives display potential selectivity for human histone deacetylase 6: Structure-based virtual screening molecular docking and dynamics simulation studies
Uba, Abdullahi Ibrahim; Yelekçi, Kemal (Elsevier Science, 2018)Human histone deacetylase 6 (HDAC6) has been shown to play a major role in oncogenic cell transformation via deacetylation of alpha-tubulin making it a viable target of anticancer drug design and development. The crystal ... -
Chemical and Biological Investigations of Allium scorodoprasum L. Flower Extracts
Dordevski, Nikoleta; Uba, Abdullahi Ibrahim; Zengin, Gokhan; Bozunovic, Jelena; Gasic, Uros; Ristanovic, Elizabeta; Ciric, Ana (Mdpi, 2023)This study was designed to investigate the impact of different extraction solvent systems on the chemical composition and biological activities of Allium scorodoprasum L. (Amaryllidaceae)-the medicinal plant that was ... -
Chemical profile, antiproliferative and antibacterial activities and docking studies of essential oil and hexane fraction of hydrosol from fresh leaf of Plectranthus amboinicus (Lour.) Spreng.
Ibrahim, Enas I. E.; Yagi, Sakina; Tzanova, Tzvetomira; Schohn, Herve; Uba, Abdullahi Ibrahim; Zengin, Gokhan (Pergamon-Elsevier Science Ltd, 2023)Essential oils are commonly extracted from plants by hydrodistillation in which an aqueous phase called hydrosol is obtained. Like essential oil, this by-product of distillation can be a source of natural bioactive molecules ... -
The design of potent HIV-1 integrase inhibitors by a combined approach of structure-based virtual screening and molecular dynamics simulation
Samorlu, Augustine S.; Yelekçi, Kemal; Uba, Abdullahi Ibrahim (Taylor & Francis Ltd, 2018)Bu araştırmanın amacı, AIDS olarak bilinen insan bağışıklık sistemine etki eden, duraksamayan ve depresif bir hastalığa neden olan HIV-1'in tedavisi için potansiyel inhibitörleri elde etmektir. HIV-1 integraz inhibitörleri, ... -
Differential Metabolomic Fingerprinting of the Crude Extracts of Three Asteraceae Species with Assessment of Their In Vitro Antioxidant and Enzyme-Inhibitory Activities Supported by In Silico Investigations
Zengin, Gokhan; Fahmy, Nouran M.; Sinan, Kouadio Ibrahime; Uba, Abdullahi Ibrahim; Bouyahya, Abdelhakim; Lorenzo, Jose M.; Yildiztugay, Evren (Mdpi, 2022)The Asteraceae is a large family, rich in ornamental, economical, and medicinally valuable plants. The current study involves the analytical and pharmacological assessment of the methanolic extracts of three less investigated ... -
Evaluating the phyto-complexity and poly-pharmacology of spices: The case of Aframomum melegueta K. Schum (Zingiberaceae)
Luca, Simon Vlad; Trifan, Adriana; Zengin, Gokhan; Sinan, Kouadio Ibrahim; Uba, Abdullahi Ibrahim; Korona-Glowniak, Izabela; Skalicka-Wozniak, Krystyna (Elsevier, 2022)The seeds of Aframomum melegueta K. Schum (grains of paradise, Zingiberaceae) are used as a common spice in African countries and a fine condiment in the European cuisine. In this study, we evaluated the phytochemical ... -
Examining the stability of binding modes of the co-crystallized inhibitors of human HDAC8 by molecular dynamics simulation
Uba, Abdullahi Ibrahim; Weako, Jackson; Keskin, Özlem; Gürsoy, Attila; Yelekçi, Kemal (Taylor & Francis Inc, 2019)Histone deacetylase (HDAC) 8 has been implicated as a potential therapeutic target in a variety of cancers neurodegenerative disorders metabolic dysregulation and autoimmune and inflammatory diseases. Several nonselective ... -
Gathering scientific evidence for a new bioactive natural ingredient: The combination between chemical profiles and biological activities of Flueggea virosa extracts
Zengin, Gokhan; Acqua, Stefano Dall'; Sinan, Kouadio Ibrahime; Uba, Abdullahi Ibrahim; Sut, Stefania; Peron, Gregorio; Etienne, Ouattara Katinan (Elsevier, 2022)Flueggea virosa (Roxb. ex Willd.) Royle is a plant with several traditional uses in tropical countries. To study the potential usefulness, extracts from stem barks and leaves of F. virosa were obtained with different ... -
Homology modeling of human histone deacetylase 10 and design of potential selective inhibitors
Uba, Abdullahi Ibrahim; Yelekçi, Kemal (Taylor & Francis Inc, 2019)Histone deacetylases (HDACs) are implicated in the pathology of various cancers, and their pharmacological blockade has proven to be promising in reversing the malignant phenotypes. However, lack of crystal structures of ... -
Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and molecular dynamics studies
Weako, Jackson; Uba, Abdullahi Ibrahim; Keskin, Özlem; Gürsoy, Attila; Yelekçi, Kemal (Elsevier, 2020)Methionine Aminopeptidases MetAPs are divalent-cofactor dependent enzymes that are responsible for the cleavage of the initiator Methionine from the nascent polypeptides. MetAPs are classified into two isoforms: namely, ... -
An In-Depth Study on the Metabolite Profile and Biological Properties of Primula auriculata Extracts: A Fascinating Sparkle on the Way from Nature to Functional Applications
Kurt-Celep, Inci; Zheleva-Dimitrova, Dimitrina; Gevrenova, Reneta; Uba, Abdullahi Ibrahim; Zengin, Gokhan; Yildiztugay, Evren; Picot-Allain, Carene Marie Nancy (Mdpi, 2022)The biological activity of the aerial part and rhizomes of Primula auriculata were assessed for the first time. The biological activities (antioxidant properties, enzyme inhibition, and AGE inhibition) as well as the ... -
Integration of in vitro and in silico approaches to assess three Astragalus species from Turkey flora: A novel spotlight from lab bench to functional applications
Zengin, Gokhan; Uba, Abdullahi Ibrahim; Ocal, Mustafa; Sharifi-Rad, Majid; Caprioli, Giovanni; Angeloni, Simone; Altunoglu, Yasemin Celik (Elsevier, 2022)Members of the genus Astragalus have a great interest as a source of natural bioactive compounds on a scientific platform. To provide multidirectional insights into three Astragalus species (A. setulosus, A. anthylloides, ... -
Intermolecular interactions in human HDAC8 crystal structures and the stability of binding modes of co-crystallized inhibitors
Yelekçi, Kemal; Uba, Abdullahi Ibrahim (Amer Chemical Soc, 2019)[Abstract Not Available] -
Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6
Uba, Abdullahi Ibrahim; Yelekçi, Kemal (Elsevier Sci Ltd, 2018)Histone deacetylase (HDAC) 6 plays a role in oncogenic transformation and cancer metastasis via tubulin deacetylation, making it a critical target for anticancer drug design. However, lack of selectivity shown by many of ... -
Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species
Omer, Haifa A. A.; Caprioli, Giovanni; Abouelenein, Doaa; Mustafa, Ahmed M.; Uba, Abdullahi Ibrahim; Ak, Gunes; Ozturk, Refiye Beyza (Mdpi, 2022)Several species within the genera Cassia or Senna have a treasure of traditional medicines worldwide and can be a promising source of bioactive molecules. The objective of the present study was to evaluate the phenolic ... -
Status of malondialdehyde, catalase and superoxide dismutase levels/activities in schoolchildren with iron deficiency and iron-deficiency anemia of Kashere and its environs in Gombe State, Nigeria
Usman, Sani Sharif; Dahiru, Musa; Abdullahir, Bashir; Abdullahir, Shariff Bilal; Maigari, Usman Muhammad; Uba, Abdullahi Ibrahim (Elsevier, 2019)Background: Iron-deficiency anemia (IDA) or iron deficiency (ID) is by far the most common form of disorder affecting the cognitive development, physical growth and school performance of children in developing countries ... -
Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives
Uba, Abdullahi Ibrahim; Karasulu, Hatice Yeşim; Karasulu, Ercüment; Birgül, Kaan; Yıldırım, Yeliz; Bekçi, Hatice; Cumaoğlu, Ahmet; Yılmaz, Özgür; Kabasakal, Levent; Küçükgüzel, Şükriye Güniz; Yelekçi, Kemal (Elsevier Masson s.r.l., 2020)In this study, (S)-naproxen thiosemicarbazides (3a-d), 1,2,4-triazoles (4a-c), triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d, 4a and 5a-p) were confirmed by FT-IR, 1H NMR,13C ... -
Which Extraction Solvents and Methods Are More Effective in Terms of Chemical Composition and Biological Activity of Alcea fasciculiflora from Turkey?
Ozturk, Refiye Beyza; Zengin, Gokhan; Sinan, Kouadio Ibrahime; Montesano, Domenico; Zheleva-Dimitrova, Dimitrina; Gevrenova, Reneta; Uba, Abdullahi Ibrahim (Mdpi, 2022)The bioactive content, antioxidant properties, and enzyme inhibition properties of extracts of Alcea fasciculiflora from Turkey prepared with different solvents (water, methanol, ethyl acetate) and extraction methods ...