Browsing PubMed İndeksli Yayınlar Koleksiyonu by Subject "Apoptosis"
Now showing items 1-7 of 7
-
Design, synthesis, molecular modeling, and bioactivity evaluation of 1,10-phenanthroline and prodigiosin (Ps) derivatives and their Copper(I) complexes against mTOR and HDAC enzymes as highly potent and effective new anticancer therapeutic drugs
(Frontiers Media Sa, 2022)Breast cancer is the second type of cancer with a high probability of brain metastasis and has always been one of the main problems of breast cancer research due to the lack of effective treatment methods. Demand for ... -
General anesthesia with thoracic epidural anesthesia in the cardiopulmonary bypass surgery reduces apoptosis by upregulating antiapoptotic protein Bcl-2
(Edizioni Minerva Medica, 2006)Aim. The aim of the paper was to investigate whether thoracic epidural anesthesia (TEA) together with general anaesthesia (GA) play a role on apoptosis in humans before cardiopulmonary bypass (CPB) before aortic cross clamp ... -
Ginkgo biloba extract regulates differentially the cell death induced by hydrogen peroxide and simvastatin
(Elsevier Science Bv, 2006)Several human diseases have been associated with the overproduction of reactive oxygen species (ROS) and subsequently various antioxidants emerged as potential therapeutic agents that scavenge ROS. As an oxidative stress ... -
A new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation
(Nature Portfolio, 2022)Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and resistant to both conventional and targeted chemotherapy. Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to decrease the incidence ... -
Protective effects of a calcium channel blocker on apoptosis in thymus of neonatal STZ-diabetic rats
(Elsevier GMBH Urban & Fischer Verlag, 2005)Streptozotocin (STZ) is known to induce insulin-dependent diabetes in experimental animals. In STZ-induced diabetes atrophy of the thymus is caused by elevated intracellular calcium levels leading to apoptosis. Hyperglycemia ... -
Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase
(Elsevier Ireland Ltd., 2004)The lipid-lowering drugs statins induce apoptosis in a variety of tumor cells. Here we investigated the apoptotic effect of the lipophilic statin simvastatin in C6 glioma cells and the underlying effects on intracellular ... -
Synthesis anticancer activity and molecular modeling of etodolac-thioether derivatives as potent methionine aminopeptidase (type II) inhibitors
(Wiley, 2018)A series of (RS)-1-{[5-(substituted)sulfanyl-4-substituted-4H-124-triazole-3-yl]methyl}-18-diethyl-1349-tetrahydropyrano[34-b]indoles (5a-v) were designed and synthesized using a five-step synthetic protocol that involves ...