Browsing Biyoinformatik ve Genetik Bölümü Koleksiyonu by Author "Şahin, H. Bahar"
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The Drosophila fragile X mental retardation protein participates in the piRNA pathway
Bozzetti, Maria Pia; Specchia, Valeria; Cattenoz, Pierre B.; Laneve, Pietro; Geusa, Annamaria; Şahin, H. Bahar; Di Tommaso, Silvia D.; Friscini, Antonella; Massari, Serafina; Diebold, Celine; Giangrande, Angela (Company of Biologists Ltd, 2015)RNA metabolism controls multiple biological processes and a specific class of small RNAs called piRNAs act as genome guardians by silencing the expression of transposons and repetitive sequences in the gonads. Defects in ... -
New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes
Abekhoukh, Sabiha; Şahin, H. Bahar; Grossi, Mauro; Zongaro, Samantha; Maurin, Thomas; Madrigal, Irene; Kazue-Sugioka, Daniele; Raas-Rothschild, Annick; Doulazmi, Mohamed; Carrera, Pilar; Stachon, Andrea; Scherer, Steven; Do Nascimento, Maria Rita Drula; Trembleau, Alain; Arroyo, Ignacio; Szatmari, Peter; Smith, Isabel M.; Mila, Montserrat; Smith, Adam C.; Giangrande, Angela; Caille, Isabelle; Bardoni, Barbara (Company of Biologists Ltd, 2017)Cytoplasmic FMRP interacting protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID) autism schizophrenia and epilepsy. It is a member of a family of proteins that is highly conserved during evolution sharing ... -
Novel Mutants of the Aubergine Gene
Şahin, H. Bahar; Karataş, Ömer Faruk; Specchia, Valeria; Di Tommaso, Silvia D.; Diebold, Celine; Bozzetti, Maria Pia; Giangrande, Angela (Taylor & Francis Inc, 2016)Aubergine is an RNA-binding protein of the Piwi clade functioning in germline in the piRNA pathway that silences transposons and repetitive sequences. Several mutations of this gene exist but they mostly result in truncated ... -
Salt inducible kinases as novel Notch interactors in the developing Drosophilaretina
Şahin, H. Bahar; Sayın, Sercan; Holder, Maxine; Bugra, Kuyaş; Çelik, Arzu (Public Library Science, 2020)Developmental processes require strict regulation of proliferation, differentiation and patterning for the generation of final organ size. Aberrations in these fundamental events are critically important in tumorigenesis ...