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Carboxylic acid derivatives display potential selectivity for human histone deacetylase 6: Structure-based virtual screening molecular docking and dynamics simulation studies
(Elsevier Science, 2018)
Human histone deacetylase 6 (HDAC6) has been shown to play a major role in oncogenic cell transformation via deacetylation of alpha-tubulin making it a viable target of anticancer drug design and development. The crystal ...
Fluorescence study on drying of iota-carrageenan gels at different temperatures prepared with various CaCl2 content
(Springer, 2011)
The influence of temperature and salt content on drying was investigated by using steady-state fluorescence (SSF) technique. Supporting gravimetric and volumetric measurements were also carried out during drying of gels ...
Synthesis and Screening of Human Monoamine Oxidase-A Inhibitor Effect of New 2-Pyrazoline and Hydrazone Derivatives
(Wiley-VCH Verlag GmbH, 2015)
A group of 35-diaryl-2-pyrazoline and hydrazone derivatives was prepared via the reaction of various chalcones with hydrazide compounds in ethanol. Twenty original compounds were synthesized. Ten of these original compounds ...
A comparison of fluorescence and UV-visible spectrometry techniques for thermal phase transitions of agarose gels
(Springer, 2015)
In this study thermoreversible phase transitions of high (HMP) and low (LMP) melting point agarose gels were investigated by using the UV-vis and fluorescence spectroscopy techniques. Pyranine was added to the aqueous ...
Spectroscopic study of film formation from polystyrene latex/TiO2 nanocomposites prepared by dip-coating method
(Wiley-Blackwell, 2014)
In this study we investigated the influence of TiO2 content and thickness of polystyrene (PS) template on film-formation behavior of PS/TiO2 composites using fluorescence and ultraviolet-visible techniques in conjunction ...
Electrical optical and fluorescence percolations in P(VAc-co-BuA)/MWCNT composite films
(Taylor & Francis Ltd, 2013)
Effects of multiwall carbon nanotube (MWCNT) addition on the electrical conductivities optical transparencies and fluorescence emissions of poly(vinyl acetate-co-butyl acrylate) (P(VAc-co-BuA))/MWCNT composite films were ...
In silico design of novel and highly selective lysine-specific histone demethylase inhibitors
(Scientific Technical Research Council Turkey-Tubitak, 2011)
Histone lysine-specific demethylase (LSD1) is involved in a wide range of epigenetic processes and plays important roles in gene silencing DNA transcription DNA replication DNA repair and heterochromatin formation. Its ...
Power of inhibition activity screening and 3D molecular modeling approaches in HDAC 8 inhibitor design
(Scientific Technical Research Council Turkey-Tubitak, 2011)
In-vitro inhibition activity screening and in-silico 3D molecular modeling approaches are important tools for design and development of specific histone deacetylase (HDAC) inhibitors. The objective of this study was to ...
Thermal Phase Transitions of IOTA Carrageenan in CaCl2 Solutions: A Fluorescence Study
(Taylor & Francis Inc, 2011)
The fluorescence technique was employed to study thermal phase transitions of iota (-) carrageenan (IC) in CaCl2 solution. IC gels underwent coil to double helix (c-h) and double helix to dimer (h-d) transitions upon ...
The Effect Of Surfaces On The Orientational Properties and Phase Transitions Peculiarities Of A Nonpolar Smectogen
(World Scientific Publ Co Pte Ltd, 2010)
The effect of thin films on the orientational and optical properties of nonpolar monolayer smectogen 4-butoxyphenyl-4'-decyloxybenzoate ((10) over barO (4) over bar) liquid crystal has been studied by polarizing microscopy ...