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Now showing items 121-130 of 132
Exploration of the binding pocket of histone deacetylases: the design of potent and isoform-selective inhibitors
(Tübitak, 2017)
Histone deacetylases (HDACs) are enzymes that act on histone proteins to remove the acetyl group and thereby regulate the
chromatin state. HDACs act not only on histone protein but also nonhistone proteins that are key ...
Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies
(Frontiers Media Sa, 2016)
The diverse cerebral mechanisms implicated in Central Nervous System (CNS) diseases together with the heterogeneous and overlapping nature of phenotypes indicated that multitarget strategies may be appropriate for the ...
Network dynamics reconstruction from data
(Scıentıfıc Technıcal Research Councıl Turkey-Tubıtak, 2020)
We consider the problem of recovering the model of a complex network of interacting dynamical units from time series of observations. We focus on typical networks which exhibit heterogeneous degrees, i.e. where the number ...
"2-pirazolin yapısındaki yeni bir bileşiğin sentezi, moleküler modellemesi ve monoaminoksidaz inhibitörü etkisinin araştırılması"
(Türkiye Halk Sağlığı Kurumu, 2018)
Amaç: Nöromediatörlerin yıkımından sorumlu olan
monoamin oksidaz (MAO) enziminin izoformlarının
(MAO-A ve -B) birçok hastalık ile yakından ilişkili olduğu;
MAO inhibitörlerinin depresyon, Parkinson ve Alzheimer
hastalığı ...
A mathematical characterization of the gel point in sol-gel transition
(IOP Publishing Ltd, 2015)
We model the sol-gel transition in terms of Susceptible-Infected-Removed (SIR) and Susceptible-Exposed-Infected-Removed (SEIR) models and compare with experimental results. We show, numerically, that the "gel point" described ...
Soman as a wrench in the works of human acetylcholinesterase: Soman induced conformational changes revealed by molecular dynamics simulations
(Amer Chemical Soc, 2014)
[Abstract Not Available]
Conductivity Percolation of Carbon Nanotubes in Polyacrylamide Gels
(Intech Europe, 2011)
[Abstract Not Available]
Intermolecular interactions in human HDAC8 crystal structures and the stability of binding modes of co-crystallized inhibitors
(Amer Chemical Soc, 2019)
[Abstract Not Available]
Investigation of intrinsic dynamics and allosteric coupling in human beta 2-adrenergic receptor
(Springer, 2017)
[Abstract Not Available]
Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives
(Elsevier Masson s.r.l., 2020)
In this study, (S)-naproxen thiosemicarbazides (3a-d), 1,2,4-triazoles (4a-c), triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d, 4a and 5a-p) were confirmed by FT-IR, 1H NMR,13C ...