Advanced Search

Show simple item record

dc.contributor.authorAlMasraf, G.
dc.contributor.authorAlbayati, S.
dc.date.accessioned2023-10-19T15:05:20Z
dc.date.available2023-10-19T15:05:20Z
dc.date.issued2021
dc.identifier.issn1742-6588
dc.identifier.urihttps://doi.org/10.1088/1742-6596/2114/1/012069
dc.identifier.urihttps://hdl.handle.net/20.500.12469/4833
dc.description3rd International Conference in Physical Science and Advanced Materials, PAM 2021 --24 September 2021 through 28 September 2021 -- --176186en_US
dc.description.abstractThis research aims to find a new approach to deal with cancer, by targeting a protein that controls the growth and increases the size of the tumour. The approach uses computer-aid drug designed to find the best drug for inhibiting f Methionine Aminopeptidase (Metap2) which is an enzyme that is responsible for starting the synthesis of new protein. The inhibition of the enzyme was found to be crucial in stopping the growth of the tumour and its development. In this research, an in-silico approach was conducted to obtain compounds that are capable of inhibiting the enzyme with non-toxic features. This is done by using Ligand-Based. The Zinc15 and National Institute of Cancer Data (NCI) Databases were screened to attain a variety of manufactured Compounds. Then, molecular docking filtration process was carried out using PyRx, and Autodock4. Finally, SwissADME protocol was used to show the ADMET properties and that compounds can permit the blood barriers and validate better pharmacokinetic properties than the Fumagillin. © 2021 Institute of Physics Publishing. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherIOP Publishing Ltden_US
dc.relation.ispartofJournal of Physics: Conference Seriesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCanceren_US
dc.subjectComputational Drug designen_US
dc.subjectDrug designen_US
dc.subjectProteinen_US
dc.subjectTumouren_US
dc.subjectAmino acidsen_US
dc.subjectBiosynthesisen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectLead compoundsen_US
dc.subjectTumorsen_US
dc.subjectAIDS drugsen_US
dc.subjectAmino peptidaseen_US
dc.subjectComputational drug designen_US
dc.subjectDrug Designen_US
dc.subjectIn-silicoen_US
dc.subjectMethionineen_US
dc.subjectMethionine aminopeptidaseen_US
dc.subjectNew approachesen_US
dc.subjectNon-toxicen_US
dc.subjectDiseasesen_US
dc.titleLead-like compounds for inhibiting Methionine amino peptidase 2 (MetAP2)en_US
dc.typeconferenceObjecten_US
dc.identifier.issue1en_US
dc.identifier.volume2114en_US
dc.departmentN/Aen_US
dc.identifier.doi10.1088/1742-6596/2114/1/012069en_US
dc.identifier.scopus2-s2.0-85123385865en_US
dc.institutionauthorN/A
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.authorscopusid57423648800
dc.authorscopusid57222873065
dc.khas20231019-Scopusen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record