Browsing Lisansüstü Eğitim Enstitüsü by Title
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In silico design and modeling of peptidomimetic drug candidates for methionine aminopeptidase 2 enzyme for prevention of cancer
(Kadir Has Üniversitesi, 2019)Birçok hastalık bir araya gelerek kanseri oluşturur. Kanser hücreleri kontrolsüz bir şekilde bölünür. Kanserde hücre çoğalması anormaldir. Yıllar içinde 200'den fazla kanser çeşidi teşhis edilmiştir. Bazı faktörler kansere ... -
In silico design of novel and highly selective cyclooxygenase-2 inhibitors
(Kadir Has Üniversitesi, 2014)For many years, prevention of inflammation is achieved by inhibition of both cyclooxygenase (COX) enzymes; the eventual outcome is gastrointestinal toxicity. Selective inhibitor design for COX-2 initialized just after ... -
In silico design of selective monoamine Oxidase B inhibitors using indane ring
(Kadir Has Üniversitesi, 2013)in the present work 209952 analogs of an indane scaffold were created using various fragment moieties at different position of indane ring. CHEMPLP module of GOLD program is utilized in the screening process. in order to ... -
In silico design of selective neuronal nitric oxide synthase inhibitors in order to prevent neurodegenerative diseases
(Kadir Has Üniversitesi, 2013)Nitric Oxide syntheses (NOS) are the family of enzymes which catalyzes the oxidation L-Arginine amino acid to nitric oxide molecule (NO) L-citrulline. Mammals contain three different NOS isozymes: Neuronal NOS (nNOS, in ... -
In silico designing of isoform-selective inhibitors against class IIA histone deacetylases
(Kadir Has Üniversitesi, 2021)The fundamental cause of human cancer is strongly influenced by down- or upregulations of epigenetic factors. Upregulated histone deacetylases (HDAC) have been shown to be effectively neutralized by the action of HDACs ... -
In silico identification of physiological substrates and inhibitors of serum paraoxonase 1 enzyme
(Kadir Has Üniversitesi, 2014)Paraoxonase 1 (PON1) as an important antioxidant enzyme against oxidative stress has been implicated in the pathogenesis of a number of disorders including cancer cardiovascular and several other diseases. Although there ... -
In Silico Inhibitor Design For Monomine Oxidase A And B Isozymes
(Kadir Has Üniversitesi, 2012)in this thesis study MAO-A and MAO-B isozymes are selected as target enzymes that have important role of regulation of diseases such as ..Parkinson Alzheimer and depression... MAO isozymes which catalyze the oxidation of ... -
In silico modeling of dopamine transporter and design of novel neuroprotective drugs for Parkinson's disease
(Kadir Has Üniversitesi, 2017)Parkinson hastalıgı (PH), substantia nigra (SN) ve corpus striatum (CS) bolgelerinde dopamin ureten noronların kaybedilmesi ile karakterize edilen bir olgudur. Yaygın olarak uygulanan tedavi dopamin noronlarının kaybolmalarının ... -
In silico screening of multi target drug for alzheimer'sdisease and parkinson's disease using pharmacophore-baseddrug discovery approach
(Kadir Has Üniversitesi, 2019)Research on neurodegenerative diseases (NDD), commonly known as Alzheimer's and Parkinson's disease are the most important concern in this aging society. Among the other causes the main suspected reasons are the production ... -
In silico screening of neuronal nitric oxide synthase enzyme inhibitors
(Kadir Has Üniversitesi, 2014)Three closely related isoforms of nitric oxide synthases (NOS) catalyze an important secondary messenger nitric oxide (NO) synthesis through oxidation of L-arginine to L-citrulline. These three NOS isoforms takes parts in ... -
In silico screening of potent histon demethylase1 (lsd1) enzyme inhibitor
(Kadir Has Üniversitesi, 2020)Histone lysine specific demethylase (LSD1) is one of the main enzymes which regulates histone demethylation which in return regulates different epigenetic processes such DNA replication and transcription also gene silencing. ... -
In silico screening of potent HIV-1 integrase inhibitors for the treatment of human immunodeficiency virus (HIV)
(Kadir Has Üniversitesi, 2018)Bu araştırmanın amacı, AIDS olarak bilinen insan bağışıklık sistemine etki eden, duraksamayan ve depresif bir hastalığa neden olan HIV-1'in tedavisi için potansiyel inhibitörleri elde etmektir. HIV-1 integraz inhibitörleri, ... -
In silico screening of potential peroxisome proliferator-activated receptors (Alpha-gamma) ppars ?/? for the treatment of human diabetic mellitus (DM)
(Kadir Has Üniversitesi, 2020)Diabetes mellitus (DM) means a metabolic ailment identified by hyperglycemia, obesity, hypertension, which can contribute to the metabolic disturbances on sugars, lipids, and protein. PPARα and PPARγ become signified the ... -
In silico screening of tangible-potential inhibitor of methionine aminopeptidase 2 for the treatment of cancer
(Kadir Has Üniversitesi, 2017)Methionine Aminopeptidases (MetAPs) are divalent-cofactor dependent enzymes that are responsible for cleaving the initiator Methionine from the newly synthesized polypeptides. These metalloproteases are classified into two ... -
Incorporating the non-expert publıic to heritage practices from below
(Kadir Has Üniversitesi, 2018)in our 21st century cultural heritage field grows to be much more dynamic participatory open to change and dialogue. The scope of cultural heritage too broadens. People who are supposed to inherit heritage are acknowledged ... -
Index composition changes around the world: A comprehensive literature review
(Kadir Has Üniversitesi, 2023-01)This paper aims to provide a comprehensive literature review on composition changes for benchmark indexes not only for popular indexes such as the S&P 500 but for also global counterparts both in the developed world and ... -
Individual freedom and the position of the supernatural in Ancient Greek and modern American tragedy
(Kadir Has Üniversitesi, 2010)The purpose of this master thesis study is to claim that in the tragedy form, it is not possible to interpret all the acts through a fatalistic reading, whether it is an Ancient Greek play or a modern play. It suggests ... -
Indoor location estimation through redundant lateration for indoor positioning system
(Kadir Has Üniversitesi, 2017)The simplest way to describe indoor Positioning Systems (iPS) is that it’s like a Global Positioning System (GPS) for indoor environments. iPS can be used to locate objects or people inside buildings typically via a mobile ... -
Indoor positioning system development
(Kadir Has Üniversitesi, 2015)Nowadays, smartphone market penetration continues to grow with developing technology. Accordingly, position detection in closed areas has become an important research area. For instance; finding a direct route to the gate ... -
The influence of business on foreign economic policy: The case of Turkey and MUSIAD
(Kadir Has Üniversitesi, 2022-09)With the effect of neo-liberal policies and globalization, especially in the last 40 years, the business world has gradually gained influence both economically and politically. In this research, we have addressed the ...