Browsing Lisansüstü Eğitim Enstitüsü by Department "Enstitüler, Lisansüstü Eğitim Enstitüsü, Biyoinformatik ve Genetik Ana Bilim Dalı"
Now showing items 1-12 of 12
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Augmented virtual crossmatch for donor-induced antibody prediction by using high resolution human leukocyte antigen typing and human leukocyte antigen epitope mapping for better donor match
(Kadir Has Üniversitesi, 2023-01)The Human Leukocyte Antigen (HLA) disparity between donors and recipients is the primary driver of Donor Specific Antibodies (DSA) formation and graft rejection after transplantation. We aimed to predict the DSA by finding ... -
Classification of distinct conformers of beta-2 adrenergic receptor based on binding affinity of ligands through docking studies
(Kadir Has Üniversitesi, 2017)?2AR is an important drug target and plays a critical role in the relaxation of pulmonary tissues and cardiovascular physiology. We have developed a strategy for classifying various ?2AR conformers as active or inactive ... -
Development of novel and potent inhibitors for gaba-at enzyme via in silico screening methods
(Kadir Has Üniversitesi, 2020)γ-aminobütirik asit aminotransferaz (GABA-AT) piridoksal 5′-fosfat (PLP)- kofaktörlü bir enzimdir ve beyinde γ-aminobutirik asit (GABA) miktarını azaltır. GABA, beyinde önemli nörolojik görevleri olan engelleyici (inhibitory) ... -
Identification of distinct communication networks in human ?2 adrenergic receptor via molecular dynamics simulation
(Kadir Has Üniversitesi, 2020)G-protein-bağlı reseptörler (GPCR), hücre dışı ligand bağlanma işlemini hücre içi tepkilere dönüştürerek çok çeşitli insan fizyolojik fonksiyonlarına aracılık eden ve yedi transmembran (TM) yapısından oluşan proteinlerdir. ... -
In silico design and modeling of peptidomimetic drug candidates for methionine aminopeptidase 2 enzyme for prevention of cancer
(Kadir Has Üniversitesi, 2019)Birçok hastalık bir araya gelerek kanseri oluşturur. Kanser hücreleri kontrolsüz bir şekilde bölünür. Kanserde hücre çoğalması anormaldir. Yıllar içinde 200'den fazla kanser çeşidi teşhis edilmiştir. Bazı faktörler kansere ... -
In silico designing of isoform-selective inhibitors against class IIA histone deacetylases
(Kadir Has Üniversitesi, 2021)The fundamental cause of human cancer is strongly influenced by down- or upregulations of epigenetic factors. Upregulated histone deacetylases (HDAC) have been shown to be effectively neutralized by the action of HDACs ... -
In silico modeling of dopamine transporter and design of novel neuroprotective drugs for Parkinson's disease
(Kadir Has Üniversitesi, 2017)Parkinson hastalıgı (PH), substantia nigra (SN) ve corpus striatum (CS) bolgelerinde dopamin ureten noronların kaybedilmesi ile karakterize edilen bir olgudur. Yaygın olarak uygulanan tedavi dopamin noronlarının kaybolmalarının ... -
In silico screening of potent histon demethylase1 (lsd1) enzyme inhibitor
(Kadir Has Üniversitesi, 2020)Histone lysine specific demethylase (LSD1) is one of the main enzymes which regulates histone demethylation which in return regulates different epigenetic processes such DNA replication and transcription also gene silencing. ... -
In silico screening of potent HIV-1 integrase inhibitors for the treatment of human immunodeficiency virus (HIV)
(Kadir Has Üniversitesi, 2018)Bu araştırmanın amacı, AIDS olarak bilinen insan bağışıklık sistemine etki eden, duraksamayan ve depresif bir hastalığa neden olan HIV-1'in tedavisi için potansiyel inhibitörleri elde etmektir. HIV-1 integraz inhibitörleri, ... -
Investigation of allosteric inhibition effect in pyruvate kinase by constrained molecular dynamics simulation method Piruvat kinazın allosterik olarak inhibe edilmesinin kısıtlanmış moleküler dinamik similasyon methodu kullanılarak incelenmesi
(Kadir Has Üniversitesi, 2021)In previous studies, our research group identified species-specific allosteric sites in glycolytic enzymes from different organisms and identified candidate inhibitory molecules that strongly interact with the residues at ... -
Screening of novel and selective inhibitors for neuronal nitric oxide synthase (nNOS) via structure-based drug design techniques
(Kadir Has Üniversitesi, 2022-01)The overproduction of nitric oxide (NO) by neuronal nitric oxide synthase (nNOS) is the main cause of several neurodegenerative diseases such as Alzheimer’s Disease (AD), Parkinson’s Disease (PD), and Multiple Sclerosis ... -
Targeting cancer epigenetic modifiers: The design of isoform-selective histone deacetylase inhibitors
(Kadir Has Üniversitesi, 2018)Epigenetic alterations are believed to be the common hallmark of human cancers. Histone deacetylase (HDAC) inhibitors have proven to be effective in cancer cases where HDACs are up-regulated. However lack of selectivity ...