Browsing by Subject "Yapı temelli ADMET öngörüsü"
Now showing items 1-1 of 1
Targeting cancer epigenetic modifiers: The design of isoform-selective histone deacetylase inhibitors Authors:
Publisher and Date:(Kadir Has University, 2018)Epigenetic alterations are believed to be the common hallmark of human cancers. Histone deacetylase (HDAC) inhibitors have proven to be effective in cancer cases where HDACs are up-regulated. However lack of selectivity of many of the HDAC inhibitors in clinical use and those at various stages of preclinical and clinical trials causes toxicity to the normal cells. it is believed that the continuous identification of isoform-selective HDAC inhibitors can eliminate this adverse effect — a task that ...