• English
    • Türkçe
  • English 
    • English
    • Türkçe
  • Login
View Item 
  •   DSpace Home
  • Araştırma Çıktıları / WOS
  • Araştırma Çıktıları / WOS
  • View Item
  •   DSpace Home
  • Araştırma Çıktıları / WOS
  • Araştırma Çıktıları / WOS
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

DNA polymorphism of Pvu II site in the lipoprotein lipase gene in patients with non-insulin dependent diabetes mellitus

Thumbnail
View/Open
DNA polymorphism of Pvu II site in the lipoprotein lipase gene in patients with non-insulin dependent diabetes mellitus.pdf (72.12Kb)
Date
2005
Author
Duman, Belgin Süsleyici
Öztürk, Melek
Yilmazer, Selma
Çaǧatay, Penbe
Hatemi, Hüsrev
Abstract
We studied the effect of variation at the lipoprotein lipase (LPL) gene locus on the susceptibility of individuals with non-insulin dependent diabetes mellitus (NIDDM) in a population of 110 NIDDM patients and 91 controls. Our objective was to study the relationship between the LPL-Pvu II polymorphism and NIDDM and lipid metabolism. PCR-RFLP was used to determine the DNA polymorphism of the sixth intron of the LPL gene. The frequencies of the genotypes in case and control groups were 29.1 and 30.8% for P+/P+
 
45.5 and 36.3% for P+/P-
 
25.5 and 33% for P-/P- respectively. There was no significant difference in frequencies of genotypes between the two groups. Logistic regression analysis revealed that triacylglycerol (TAG) and apolipoprotein E levels were associated with NIDDM whereas Pvu II genotypes were not found as independent risk factors for the disease. Overall this study demonstrates the role of the Pvu II polymorphism in the LPL gene in modulating plasma lipid/lipoprotein levels in patients with NIDDM. Copyright (c) 2004 John Wiley & Sons Ltd.
 

Source

Cell Biochemistry and Function

Issue

6

Volume

23

Pages

399-404

URI

https://hdl.handle.net/20.500.12469/116
https://dx.doi.org/10.1027/cbf.1162

Collections

  • Araştırma Çıktıları / PubMed [194]
  • Araştırma Çıktıları / Scopus [1565]
  • Araştırma Çıktıları / WOS [1518]

Keywords

NIDDM
Lipoprotein lipase
Polymorphism
Pvu II
Lipoprotein

Share


DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateBy AuthorsBy TitlesBy SubjectsBy TypesBy LanguagesBy DepartmentsBy PublishersBy KHAS AuthorsBy Access TypesThis CollectionBy Issue DateBy AuthorsBy TitlesBy SubjectsBy TypesBy LanguagesBy DepartmentsBy PublishersBy KHAS AuthorsBy Access Types

My Account

LoginRegister

Statistics

View Google Analytics Statistics

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV