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Programmed cell death in heart failure: Review [Programlı hücre ölümünün kalp yetersizliǧindeki yeri]

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PROGRAMMED CELL DEATH IN HEART FAILURE REVIEW.pdf (203.8Kb)
Date
2005
Author
Süsleyici Duman, Belgin
Türkoǧlu, Çavlan
Öztürk, Melek
Abstract
The molecular and biochemical mechanisms of programmed cell death also known as apoptosis have not yet to be fully elucidated. Apoptosis is characterized by active intracellular communication loss of cellular attachment cell shrinkage DNA fragmentation and phagocytosis. Recently accumulated evidence indicates that apoptosis is involved in both physiological and pathophysiological processes of heart failure. Many factors have been identified that induce cardiomyocyte apoptosis during heart failure. However many questions remain to be answered regarding the pathophysiological triggers of apoptosis and their mechanisms. As such due to the incipient state of research regarding the question as to whether apoptotic inhibition delays or prevents heart failure it appears advanced molecular and pharmaco-genomic studies will be essential in identifying potential targets in prospective therapies for the prevention of apoptosis. Copyright © 2005 by Türkiye Klinikleri.

Source

Turkiye Klinikleri Journal of Medical Sciences

Issue

1

Volume

25

Pages

85-92

URI

https://hdl.handle.net/20.500.12469/1684
https://www.turkiyeklinikleri.com/article/tr-programli-hucre-olumunun-kalp-yetersizligindeki-yeri-7282.html

Collections

  • Araştırma Çıktıları / Scopus [1565]

Keywords

Apoptosis
Heart failure

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