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Antihepatitis B response to hepatitis B vaccine administered simultaneously with tetanus toxoid in nonresponder individuals

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Antihepatitis B response to hepatitis B vaccine administered simultaneously with tetanus toxoid in nonresponder individuals.pdf (53.79Kb)
Date
2002
Author
Sönmez, Emine
Sonmez, Ali Suha
Bayindir, Yaşar
Coskun, Diler
Ariturk, Sedat
Abstract
In this prospective study our aim was to test the effect of simultaneous administration of preS2 and S containing recombinant hepatitis B vaccine (S2SRHB) with tetanus toxoid (TT) to the individuals who did not respond after three doses of hepatitis B vaccine previously. There were three groups (healthy individuals pregnant women hemodialysis patients) each was divided into two subgroups as groups A and B. Group A received S2SRHB + TT and group B received only S2SRHB. We found that in groups receiving both vaccines both seroconversion rate and antibody titer level were significantly higher (P < 0.05). In conclusion simultaneous administration of S2SRHB + TT is more effective than administration of S2SRHB alone. (C) 2002 Elsevier Science Ltd. All rights reserved.

Source

Vaccine

Volume

21

Pages

243-246

URI

https://hdl.handle.net/20.500.12469/201
https://doi.org/10.1016/S0264-410X(02)00452-8

Collections

  • Araştırma Çıktıları / PubMed [187]
  • Araştırma Çıktıları / Scopus [1345]
  • Araştırma Çıktıları / WOS [1335]

Keywords

Hepatitis B vaccine
Tetanus toxoid
Nonresponder

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