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New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes

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New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes.pdf (2.024Mb)
Date
2017
Author
Abekhoukh, Sabiha
Şahin, H. Bahar
Grossi, Mauro
Zongaro, Samantha
Maurin, Thomas
Madrigal, Irene
Kazue-Sugioka, Daniele
Raas-Rothschild, Annick
Doulazmi, Mohamed
Carrera, Pilar
Stachon, Andrea
Scherer, Steven
Do Nascimento, Maria Rita Drula
Trembleau, Alain
Arroyo, Ignacio
Szatmari, Peter
Smith, Isabel M.
Mila, Montserrat
Smith, Adam C.
Giangrande, Angela
Caille, Isabelle
Bardoni, Barbara
Abstract
Cytoplasmic FMRP interacting protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID) autism schizophrenia and epilepsy. It is a member of a family of proteins that is highly conserved during evolution sharing high homology with its Drosophila homolog dCYFIP. CYFIP1 interacts with the Fragile X mental retardation protein (FMRP encoded by the FMR1 gene) whose absence causes Fragile X syndrome and with the translation initiation factor eIF4E. It is a member of theWAVE regulatory complex (WRC) thus representing a link between translational regulation and the actin cytoskeleton. Here we present data showing a correlation between mRNA levels of CYFIP1 and other members of the WRC. This suggests a tight regulation of the levels of the WRC members not only by post-translational mechanisms as previously hypothesized. Moreover we studied the impact of loss of function of both CYFIP1 and FMRP on neuronal growth and differentiation in two animal models -fly and mouse. We show that these two proteins antagonize each other's function not only during neuromuscular junction growth in the fly but also during new neuronal differentiation in the olfactory bulb of adult mice. Mechanistically FMRP and CYFIP1 modulate mTor signaling in an antagonistic manner likely via independent pathways supporting the results obtained in mouse as well as in fly at the morphological level. Collectively our results illustrate a new model to explain the cellular roles of FMRP and CYFIP1 and the molecular significance of their interaction.

Source

Disease Models & Mechanisms

Issue

4

Volume

10

Pages

463-474

URI

https://hdl.handle.net/20.500.12469/356
https://doi.org/10.1242/dmm.025809

Collections

  • Araştırma Çıktıları / Scopus [1565]
  • Araştırma Çıktıları / WOS [1518]
  • Biyoinformatik ve Genetik / Bioinformatics and Genetics [220]

Keywords

Fragile X
Intellectual disability
Autism
CYFIP1
BP1-BP2 deletion

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