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Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening ADMET prediction and molecular dynamics simulation assay
(Taylor & Francis Inc, 2018)
Histone deacetylases (HDACs) have gained increased attention as targets for anticancer drug design and development. HDAC inhibitors have proven to be effective for reversing the malignant phenotype in HDAC-dependent cancer ...
Electrical and optical percolations in PMMA/GNP composite films
(Taylor & Francis Ltd, 2018)
Effects of graphene nanoplatelet (GNP) addition on the electrical conductivity and optical absorbance of poly(methyl methacrylate)/graphene nanoplatelet (PMMA/GNP) composite films were studied. Optical absorbance and two ...
Ligand-binding affinity of alternative conformers of human beta(2)-adrenergic receptor in the presence of intracellular loop 3 (ICL3) and their potential use in virtual screening studies
(Wiley, 2019)
This study investigates the structural distinctiveness of orthosteric ligand-binding sites of several human beta(2) adrenergic receptor (beta(2)-AR) conformations that have been obtained from a set of independent molecular ...
Optical energy band gap of PAAm-GO composites
(Elsevier Science, 2018)
Graphene oxide (GO) can be used as an electron acceptor for polymers. The generation of the exciton in such materials is intimately related to the optical band gap. Polyacrylamide (PAAm) - graphene oxide (GO) composites ...
Temperature Effect on the Elasticity of Acrylamide-n-Isopropylacrylamide Copolymers
(Taylor & Francis Inc, 2018)
Acrylamide (AAm) - N-isopropylacrylamide (NIPA) copolymers were prepared via free radical crosslinking copolymerization with various weight percentages (wt%) of AAm and NIPA. The temperature dependence of the compressive ...
Epitope Based Hla Matching By Using Antibody Reactivity With High Resolution Allele Typing And Hlamatchmaker Algorithm Based Software
(Wiley, 2017)
[Abstract Not Available]
Fluorescence technique for monitoring swelling of PAAm-kappa-carrageenan gel composites
(Shaker Publishing, 2009)
Steady-state fluorescence (SSF) technique was employed for studying swelling of polyacrylamide (PAAm) gels with various content of kappa- carrageenan. Disc shaped composite gels were prepared by free-radical cross/inking ...
Synthesis anticancer activity and molecular modeling of etodolac-thioether derivatives as potent methionine aminopeptidase (type II) inhibitors
(Wiley, 2018)
A series of (RS)-1-{[5-(substituted)sulfanyl-4-substituted-4H-124-triazole-3-yl]methyl}-18-diethyl-1349-tetrahydropyrano[34-b]indoles (5a-v) were designed and synthesized using a five-step synthetic protocol that involves ...
Oxygen Diffusion into Polymer-Clay Composite Films as a Function of Clay Content and Temperature
(Wiley-VCH Verlag GmbH, 2009)
A simple fluorescence technique is proposed for the measurement of the diffusion coefficient of oxygen into polystyrene-clay composite films as a function of clay content and temperature. The composite films were prepared ...
Mechanical properties of graphene oxide-polyacrylamide composites before and after swelling in water
(Springer, 2018)
Polyacrylamide (PAAm) hydrogels have been proposed for use as promising biomaterials in biomedical and tissue engineering but their poor mechanical and water-retention properties have hindered their development. Graphene ...