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In silico design of selective monoamine Oxidase B inhibitors using indane ring
(Kadir Has Üniversitesi, 2013)
in the present work 209952 analogs of an indane scaffold were created using various fragment moieties at different position of indane ring. CHEMPLP module of GOLD program is utilized in the screening process. in order to ...
De novo selective inhibitor design to neuronal NOS enzyme and exploration of the binding site
(Kadir Has Üniversitesi, 2013)
Neural Nitric Oxide Synthase (nNOS) is an enzyme that plays a significant role in neural signal transmission among brain cells by carrying on Nitric Oxide(NO) generation. nNOS is one of the member of Nitric Oxide Synthase ...
In silico design of selective neuronal nitric oxide synthase inhibitors in order to prevent neurodegenerative diseases
(Kadir Has Üniversitesi, 2013)
Nitric Oxide syntheses (NOS) are the family of enzymes which catalyzes the oxidation L-Arginine amino acid to nitric oxide molecule (NO) L-citrulline. Mammals contain three different NOS isozymes: Neuronal NOS (nNOS, in ...