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In silico screening of tangible-potential inhibitor of methionine aminopeptidase 2 for the treatment of cancer
(Kadir Has Üniversitesi, 2017)
Methionine Aminopeptidases (MetAPs) are divalent-cofactor dependent enzymes that are responsible for cleaving the initiator Methionine from the newly synthesized polypeptides. These metalloproteases are classified into two ...
De novo selective inhibitor design to neuronal NOS enzyme and exploration of the binding site
(Kadir Has Üniversitesi, 2013)
Neural Nitric Oxide Synthase (nNOS) is an enzyme that plays a significant role in neural signal transmission among brain cells by carrying on Nitric Oxide(NO) generation. nNOS is one of the member of Nitric Oxide Synthase ...
In silico design of novel and highly selective cyclooxygenase-2 inhibitors
(Kadir Has Üniversitesi, 2014)
For many years, prevention of inflammation is achieved by inhibition of both cyclooxygenase (COX) enzymes; the eventual outcome is gastrointestinal toxicity. Selective inhibitor design for COX-2 initialized just after ...
In silico screening of neuronal nitric oxide synthase enzyme inhibitors
(Kadir Has Üniversitesi, 2014)
Three closely related isoforms of nitric oxide synthases (NOS) catalyze an important secondary messenger nitric oxide (NO) synthesis through oxidation of L-arginine to L-citrulline. These three NOS isoforms takes parts in ...