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Absolute configuration and biological profile of pyrazoline enantiomers as MAO inhibitory activity
(Wiley, 2019)
A new racemic pyrazoline derivative was synthesized and resolved to its enantiomers using analytic and semipreparative high-pressure liquid chromatography. The absolute configuration of both fractions was established using ...
Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities
(Taylor & Francis Inc, 2019)
Parkinson's disease (PD) is characterized by the loss of dopamine-generating neurons in the substantia nigra and corpus striatum. Current treatments alleviate PD symptoms rather than exerting neuroprotective effect on ...
Potent inhibitors designed for methionine aminopeptidase II using pharmocophore modeling /
(Kadir Has Üniversitesi, 2019)
Metaloenzimlerden Metiyonin Aminopeptidazlar (MetAP2), yeni sentezlenmiş polipep-titlerin başından metionin amino asidini kesmekle sorumludur. MetAP2'nin seçimli olarak engellenmesi damar oluşumunu baskıladığını, katı ...
Intermolecular interactions in human HDAC8 crystal structures and the stability of binding modes of co-crystallized inhibitors
(Amer Chemical Soc, 2019)
[Abstract Not Available]