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In silico design and modeling of coumarin derivatives as selective monoamine oxidase a inhibitors
(Kadir Has Üniversitesi, 2014)
Selective and reversible inhibition of Monoamine Oxidase (MAO) isoenzymes has an important place in treatment of various neurological disorders. Out of the two isoforms of Monoamine Oxidase enzymes inhibition of MAO-A have ...
In silico design of novel and highly selective cyclooxygenase-2 inhibitors
(Kadir Has Üniversitesi, 2014)
For many years, prevention of inflammation is achieved by inhibition of both cyclooxygenase (COX) enzymes; the eventual outcome is gastrointestinal toxicity. Selective inhibitor design for COX-2 initialized just after ...