dc.contributor.author | Tatar, Gamze Bora | |
dc.contributor.author | Tokluman, Tenzile Deniz | |
dc.contributor.author | Yelekçi, Kemal | |
dc.contributor.author | Yurter, Hayat | |
dc.date.accessioned | 2019-06-27T08:05:03Z | |
dc.date.available | 2019-06-27T08:05:03Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1300-0527 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12469/1023 | |
dc.identifier.uri | https://doi.org/10.3906/kim-1107-34 | |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/121953 | |
dc.description.abstract | In-vitro inhibition activity screening and in-silico 3D molecular modeling approaches are important tools for design and development of specific histone deacetylase (HDAC) inhibitors. The objective of this study was to investigate the consistency between these 2 approaches. The HDAC 8 inhibition activities of 8 randomly selected different carboxylic acid derivatives were screened and in-vitro experimental results were compared with in-silico molecular modeling calculations. This study demonstrated that there is no sole gold standard technique for inhibitor design and it was concluded that a combination of molecular modeling and activity screening assays will ensure more comprehensive and dependable results. | en_US] |
dc.language.iso | eng | en_US |
dc.publisher | Scientific Technical Research Council Turkey-Tubitak | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Carboxylic acids | en_US |
dc.subject | HDAC 8 inhibitor | en_US |
dc.subject | Activity screening | en_US |
dc.subject | 3D molecular modeling | en_US |
dc.title | Power of inhibition activity screening and 3D molecular modeling approaches in HDAC 8 inhibitor design | en_US |
dc.type | article | en_US |
dc.identifier.startpage | 861 | en_US |
dc.identifier.endpage | 870 | |
dc.relation.journal | Turk J Chem | en_US |
dc.identifier.issue | 6 | |
dc.identifier.volume | 35 | en_US |
dc.department | Fakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Biyoinformatik ve Genetik Bölümü | en_US |
dc.identifier.wos | WOS:000299013000004 | en_US |
dc.identifier.doi | 10.3906/kim-1107-34 | en_US |
dc.identifier.scopus | 2-s2.0-81255177496 | en_US |
dc.institutionauthor | Yelekçi, Kemal | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.trdizinid | 121953 | en_US |