Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed by Institution Author "Akdoğan, Ebru Demet"
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Exploring distinct binding site regions of beta(2)-adrenergic receptor via coarse-grained molecular dynamics simulations
Cakan, Sibel; Akdoğan, Ebru Demet (Scientific Technical Research Council Turkey-Tubitak, 2013)beta(2)-Adrenergic receptor (beta(2)AR) is a G protein-coupled receptor that is highly flexible and able to recognize a wide range of ligands through its conformational variations. Active and inactive conformations revealed ... -
How an Inhibitor Bound to Subunit Interface Alters Triosephosphate Isomerase Dynamics
Kürkçüoğlu, Zeynep; Fındık, Doğa; Akdoğan, Ebru Demet; Doruker, Pemra (Cell Press, 2015)The tunnel region at triosephosphate isomerase (TIM)'s dimer interface distant from its catalytic site is a target site for certain benzothiazole derivatives that inhibit TIM's catalytic activity in Trypanosoma cruzi the ... -
In silico design of novel and highly selective lysine-specific histone demethylase inhibitors
Akdoğan, Ebru Demet; Erman, Burak; Yelekçi, Kemal (Scientific Technical Research Council Turkey-Tubitak, 2011)Histone lysine-specific demethylase (LSD1) is involved in a wide range of epigenetic processes and plays important roles in gene silencing DNA transcription DNA replication DNA repair and heterochromatin formation. Its ... -
Kompleks Proteinlerin Farklı Bölgelerindeki Amino Asit Dağılımı ve Etkileşimini Etkileyen Çevresel ve Yapısal Faktörlerin İncelenmesi: Hücre Zarı Ortamı, Sekonder Yapı ve Kompleks Yapıdaki Monomer Sayısı
Akdoğan, Ebru Demet (2020)Bu projede kompleks yapılardaki amino asit türleri, dagılımları, görülme sıklıkları, çözücü ersilir yüzey alanı (SASA), arayüzeyde etkilesen amino asit çiftlerinin görülme sıklıkları ve kontakt derecelerini etkileyen yapısal ...