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dc.contributor.authorDuman, Belgin Süsleyici
dc.contributor.authorTürkoğlu, Caner
dc.contributor.authorAkpinar, Belhhan
dc.contributor.authorGüden, Mustafa
dc.contributor.authorVertii, Alexey
dc.contributor.authorDak, Esranur
dc.contributor.authorÇağatay, Tülin
dc.contributor.authorGünay, Demet
dc.contributor.authorBuyukdevrim, Ahmet Sevim
dc.date.accessioned2019-06-27T08:00:54Z
dc.date.available2019-06-27T08:00:54Z
dc.date.issued2004
dc.identifier.issn0003-9985
dc.identifier.issn1543-2165
dc.identifier.urihttps://hdl.handle.net/20.500.12469/151
dc.identifier.urihttps://www.archivesofpathology.org/doi/full/10.1043/1543-2165(2004)128%3C869:LLGPAL%3E2.0.CO;2
dc.description.abstractContext.-Lipoprotein lipase (LPL) plays a central role in lipid metabolism hydrolyzing triglyceride in chylomicrons and very-low-density lipoproteins. The PvuII polymorphic variant of LPL gene is common and might affect risk of coronary artery disease (CAD). Objective.-Our aim was to determine whether LPL-PvuII polymorphism can be considered to be an independent risk factor or a predictor for CAD in Turkish subjects. Design.-We used polymerase chain reaction and restriction enzyme digestion to determine the distribution of the previously described C-->T transition that causes a PvuII polymorphism in intron 6 among healthy blood donors of Turkish origin and among angiographically confirmed CAD patients with comparable ethnic backgrounds. Results.-For the PvuII genotypes within the CAD group (n = 80) the +/- genotype was found in 39 individuals (48.8%) whereas 25 (31.3%) carried the +/+ genotype and 14 (17.5%) carried the -/- genotype. Within the control group (n = 49) the -/- genotype was found in 19 individuals (38.8%) 16 (32.7%) carried the +/- genotype and 14 (28.6%) carried the +/+ genotype. The genotype frequency distribution was significantly different (P = .049) in the CAD and control study groups. The most frequent genotype among CAD patients was +/-
dc.description.abstractthis genotype was more frequent in patients than in control subjects. However the -/- genotype was more prevalent in the control group. Lipoprotein lipase-PvuII polymorphism was found to be associated with fasting total cholesterol and low-density lipoprotein cholesterol levels. The +/+ genotype was found to have higher levels of total cholesterol and low-density lipoprotein cholesterol in both the CAD and control groups. Conclusion.-There was a difference in the distribution of LPL-PvuII genotypes between the healthy subjects and the patients with CAD. Lipoprotein lipase-PvuII polymorphisms were not detected as independent risk factors for CAD in this study group but had associations with lipid levels.
dc.language.isoEnglish
dc.publisherCOLL AMER PATHOLOGISTS
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleLipoprotein lipase gene polymorphism and lipid profile in coronary artery disease
dc.typeArticle
dc.identifier.startpage869
dc.identifier.endpage874
dc.relation.journalArchives of Pathology & Laboratory Medicine
dc.identifier.issue8
dc.identifier.volume128
dc.identifier.wosWOS:000222998800007


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