Browsing Tez Koleksiyonu by Department "Enstitüler, Lisansüstü Eğitim Enstitüsü, Hesaplamalı Biyoloji ve Biyoinformatik Ana Bilim Dalı"
Now showing items 1-20 of 22
-
Applications of machine learning in classification of biological data
(Kadir Has Üniversitesi, 2018)Machine learning enables computers learn from the data. it has a wide range of application areas. Computational biology and bioinformatics are some areas in which machine learning applications provide accurate solutions ... -
Corrected PRA positivity rates for hypersensitized patients in Turkish population with calculated PRA-cPRA software
(Kadir Has Üniversitesi, 2017)Yüksek PRA (Panel Reaktif Antikor) oranları, böbrek nakli şansını düşürebilir ve nakilden önce uzun süre beklemeye yol açabilir. cPRA (Hesaplamalı Panel Reaktif Antikor), kabul edilemez (uyumsuz) HLA (Human Lökosit Antijen) ... -
Deep learning applications on biological data
(Kadir Has Üniversitesi, 2018)Biological sciences and medicine have been rapidly becoming data-intensive disciplines. Machine learning algorithms in particular deep learning methods are becoming essential tools of data analysis to facilitate our ... -
Design and implementation of a smart medicine regulator for elderly people with parkinson and alzheimer diseases
(Kadir Has Üniversitesi, 2023)Parkinson ve Alzheimer, esas olarak beyin performansını, özellikle de sinir sistemini etkileyen ilerleyici hastalıklardır. İlk başta, Parkinson hastalığı hastayı etkileyeb ilir ve titreme veya sallanma gib i kontrolsüz ... -
Design of novel and potent inhibitors for mPGES-1 enzyme via in silico screening
(Kadir Has Üniversitesi, 2021)To prevent inflammation in the body, non-steroidal anti-inflammatory drugs act by suppressing PGE2 production as a result of non-selective inhibition of both COX-1 and COX-2 enzymes. As a result of the inhibition of COX-1 ... -
Designing of selective and potent inhibitors against histone deacetylase enzymes (HDAC6 VE HDAC10) via in silico screening and molecular modeling techniques for the treatment of cancer
(Kadir Has Üniversitesi, 2021)HDACs are the class of enzymes that are involved in the process of cancer development by removing the acetyl groups from histone protein, inducing chromatin condensation and in this way regulating the expression of tumor ... -
Enhanced structural, optical and antibacterial properties of ZnO doped TiO2 composites
(Kadir Has Üniversitesi, 2021)Günlük yaşamda bakteriyel enfeksiyonlar insan sağlığı için yaygın bir sorundur. Bu nedenle araştırmacılar, antibakteriyel enfeksiyonları ve çevresel kirleticileri önlemek için değerli materyaller arıyorlar. İnce film, ... -
Exploring distinct conformers of B2-adrenergic receptor via coarse-grained molecular dynamics simulations
(Kadir Has Üniversitesi, 2012)ß2AR, G protein bağlantılı reseptör ve birçok ilaç için hedef moleküldür. Reseptörünson derece esnek olan yapısı bir çok ligant molekülünü tanıma özelliği sağlar. Sonyıllarda yapılan kristalografik çalışmalar reseptörün ... -
Homology modeling and normal mode analysis of human NR1-NR2A NMDA type receptors
(Kadir Has Üniversitesi, 2017)N-Methyl-D-Aspartate (NMDA) receptors are ionotropic glutamate receptors located in the membrane of the nerve cells. The normal receptor activity has a vital importance in consciousness and normal brain functions. Neuronal ... -
Identification of species-specific allosteric binding sites in phosphofructokinase for drug design studies
(Kadir Has Üniversitesi, 2020)Glikolitik yolaktaki en kritik enzimlerden biri olan fosfofruktokinaz (PFK), türe özgü ilaç tasarım çalışmalarında kullanılmak üzere hedeflenmiş ve bakteri, parazit ve insan olmak üzere üç türdeki allosterik bağlanma ... -
Identifying the working principles of human DNA methyltransferase 3A enzyme by computational methods
(Kadir Has Üniversitesi, 2021)DNA metilasyonu, metilasyon deseninin sürdürülmesi ve oluşturulmasından sorumlu epigenetik mekanizmalardan biridir. DNA metiltransferaz 3 (DNMT3) enzim ailesi DNA'nın sıfırdan metilasyonunu düzenler bu nedenle de novo ... -
In silico design and modeling of coumarin derivatives as selective monoamine oxidase a inhibitors
(Kadir Has Üniversitesi, 2014)Selective and reversible inhibition of Monoamine Oxidase (MAO) isoenzymes has an important place in treatment of various neurological disorders. Out of the two isoforms of Monoamine Oxidase enzymes inhibition of MAO-A have ... -
In silico design of novel and highly selective cyclooxygenase-2 inhibitors
(Kadir Has Üniversitesi, 2014)For many years, prevention of inflammation is achieved by inhibition of both cyclooxygenase (COX) enzymes; the eventual outcome is gastrointestinal toxicity. Selective inhibitor design for COX-2 initialized just after ... -
In silico identification of physiological substrates and inhibitors of serum paraoxonase 1 enzyme
(Kadir Has Üniversitesi, 2014)Paraoxonase 1 (PON1) as an important antioxidant enzyme against oxidative stress has been implicated in the pathogenesis of a number of disorders including cancer cardiovascular and several other diseases. Although there ... -
In silico screening of neuronal nitric oxide synthase enzyme inhibitors
(Kadir Has Üniversitesi, 2014)Three closely related isoforms of nitric oxide synthases (NOS) catalyze an important secondary messenger nitric oxide (NO) synthesis through oxidation of L-arginine to L-citrulline. These three NOS isoforms takes parts in ... -
In silico screening of potential peroxisome proliferator-activated receptors (Alpha-gamma) ppars ?/? for the treatment of human diabetic mellitus (DM)
(Kadir Has Üniversitesi, 2020)Diabetes mellitus (DM) means a metabolic ailment identified by hyperglycemia, obesity, hypertension, which can contribute to the metabolic disturbances on sugars, lipids, and protein. PPARα and PPARγ become signified the ... -
In silico screening of tangible-potential inhibitor of methionine aminopeptidase 2 for the treatment of cancer
(Kadir Has Üniversitesi, 2017)Methionine Aminopeptidases (MetAPs) are divalent-cofactor dependent enzymes that are responsible for cleaving the initiator Methionine from the newly synthesized polypeptides. These metalloproteases are classified into two ... -
Investigation of species-specific allosteric binding sites in glycolytic enzymes via AlloSigMA and molecular dynamics simulations
(Kadir Has Üniversitesi, 2021)In previous studies of our research group, allosteric sites have been proposed to be used as drug targets in species-specific drug design studies for phosphofructokinase (PFK), glyceraldehyde-3 phosphate dehydrogenase ... -
De novo selective inhibitor design to neuronal NOS enzyme and exploration of the binding site
(Kadir Has Üniversitesi, 2013)Neural Nitric Oxide Synthase (nNOS) is an enzyme that plays a significant role in neural signal transmission among brain cells by carrying on Nitric Oxide(NO) generation. nNOS is one of the member of Nitric Oxide Synthase ... -
Oscillations and chaos in gene network models
(Kadir Has Üniversitesi, 2017)Oscillations and chaos have always been interesting topics in the theory of dynamical systems. In systems biology, oscillations emerging from gene networks are known to be widespread as in circadian oscillations, various ...