Show simple item record

dc.contributor.authorYılmaz, Mert
dc.contributor.authorEner, Serdar
dc.contributor.authorAkalın, Halis
dc.contributor.authorSağdıç, Kadir
dc.contributor.authorSerdar, O. Akin
dc.contributor.authorCengiz, Mete
dc.date.accessioned2019-06-27T08:01:07Z
dc.date.available2019-06-27T08:01:07Z
dc.date.issued1999
dc.identifier.issn0267-6591
dc.identifier.urihttps://hdl.handle.net/20.500.12469/264
dc.identifier.urihttps://doi.org/10.1177/026765919901400308
dc.description.abstractThe systemic inflammatory response to cardiopulmonary bypass (CPB) is associated with increased production of cytokines. This systemic inflammatory response characterized by the activation of interleukin-6 (IL-6) and interleukin-8 (IL-8) during and after CPB is well documented. A prospective randomized double-blind study was performed so as to understand the effects of low-dose methyl prednisolone sodium succinate (MPSS) on the circulating levels of serum cytokines and clinical outcome. Twenty patients were randomly divided into two groups on the basis of the administration of low-dose(1 mg/kg) MPSS in = 10) and placebo in = 10) into the pump prime solution. All patients were scheduled to undergo a primary
dc.description.abstractelective coronary artery bypass grafting operation. Patients receiving concurrent corticosteroids salicylates dipyridamol or anticoagulants were excluded from the study. Other exclusion criteria were concurrent chronic obstructive pulmonary disease chronic renal failure insulin-dependent diabetes congestive cardiac failure peptic ulcer history prior cardiac operations recent tin a one-month period) myocardial infarction and steroid dependency. Mild systemic hypothermia (30-32 degrees C rectal) was assured during the CPB. Four blood samples were drawn from the radial artery catheter immediately before starting CPB (T1) following protamine administration (T2) and at 24 (T3) and 48 h (T4) after completion of CPB. In each sample creatine kinase-myocardial band (CK-MB) white blood cell (WBC) IL-6 and IL-8 levels were measured. IL-6 and IL-8 concentrations were measured by enzyme immunoassay and enzyme-linked immunoabsorbant assay methods.
dc.language.isoEnglish
dc.publisherArnold Hodder Headline Plc.
dc.titleEffect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation
dc.typeArticle
dc.identifier.startpage201
dc.identifier.endpage206
dc.relation.journalPerfusion
dc.identifier.issue3
dc.identifier.volume14
dc.identifier.wosWOS:000082332100008
dc.identifier.doi10.1177/026765919901400308
dc.contributor.khasauthorYılmaz, Mert


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record