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Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities
(Taylor & Francis Inc, 2019)
Parkinson's disease (PD) is characterized by the loss of dopamine-generating neurons in the substantia nigra and corpus striatum. Current treatments alleviate PD symptoms rather than exerting neuroprotective effect on ...
Detached eddy simulation of shallow mixing layer development between parallel streams
(Elsevier Science Bv, 2015)
Results of a high resolution Detached Eddy Simulation (DES) are used to characterize the evolution of a shallow mixing layer developing between two parallel streams in a long open channel with a smooth flat bed and medium ...
Markov-modulated analysis of a spare parts system with random lead times and disruption risks
(Elsevier Science Bv, 2018)
Spare parts supply chains are highly dependent on the dynamics of their installed bases. A decreasing number of capital products in use increases the nonstationary supply-side risk especially towards the end-of-life of ...
The neural gamma(2)alpha(1)beta(2)alpha(1)beta(2) gamma amino butyric acid ion channel receptor: structural analysis of the effects of the ivermectin molecule and disulfide bridges
(Springer, 2018)
While similar to 30% of the human genome encodes membrane proteins only a handful of structures of membrane proteins have been resolved to high resolution. Here we studied the structure of a member of the Cys-loop ligand ...
Carboxylic acid derivatives display potential selectivity for human histone deacetylase 6: Structure-based virtual screening molecular docking and dynamics simulation studies
(Elsevier Science, 2018)
Human histone deacetylase 6 (HDAC6) has been shown to play a major role in oncogenic cell transformation via deacetylation of alpha-tubulin making it a viable target of anticancer drug design and development. The crystal ...
Low-Complexity MAP-Based Successive Data Detection for Coded OFDM Systems Over Highly Mobile Wireless Channels
(IEEE-INST Electrical Electronics Engineers Inc, 2011)
This paper is concerned with the challenging and timely problem of data detection for coded orthogonal frequency-division multiplexing (OFDM) systems in the presence of frequency-selective and very rapidly time varying ...
A Fuzzy AHP-TOPSIS-Based Group Decision-Making Approach to IT Personnel Selection
(Springer, 2018)
Global competition and the rapid development of information technologies force organizations to continuously change their ways. Nowadays organizations need personnel who make a difference through innovative ideas and who ...
Thermal Phase Transitions of IOTA Carrageenan in CaCl2 Solutions: A Fluorescence Study
(Taylor & Francis Inc, 2011)
The fluorescence technique was employed to study thermal phase transitions of iota (-) carrageenan (IC) in CaCl2 solution. IC gels underwent coil to double helix (c-h) and double helix to dimer (h-d) transitions upon ...
Modelling of Swelling by the Fluorescence Technique in Kappa Carrageenan Gels
(Amer Inst Physics, 2011)
Kappa (-kappa) carrageenan gels prepared with various carrageenan concentrations in pure water were completely dried and then swelled in water vapor. Steady state fluorescence measurements were performed using a spectrometer ...
The Effect Of Surfaces On The Orientational Properties and Phase Transitions Peculiarities Of A Nonpolar Smectogen
(World Scientific Publ Co Pte Ltd, 2010)
The effect of thin films on the orientational and optical properties of nonpolar monolayer smectogen 4-butoxyphenyl-4'-decyloxybenzoate ((10) over barO (4) over bar) liquid crystal has been studied by polarizing microscopy ...