Browsing PubMed İndeksli Yayınlar Koleksiyonu by Title
Now showing items 165-184 of 378
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Hemodilution during off-pump coronary artery bypass grafting: Can we improve flow and reduce hypercoagulability?
(Forum Multimedia Publishing LLC., 2003)Background: The aim of this study was to compare intraoperative coronary graft flows performed on pump and off pump and to evaluate the effects of hemodilution on coronary graft flows in off-pump coronary artery bypass ... -
Hip fracture-dislocation (Pipkin type IV) associated with an apparent traumatic aortic valve rupture. Case history
(2001)Traumatic aortic valve rupture with resultant aortic insufficiency is a rare complication of blunt trauma. Here reported is a case with a posterior fracture-dislocation of the hip (Pipkin type-IV) and an undisplaced sternum ... -
Histone Deacetylase Inhibition Activity and Molecular Docking of (E )-Resveratrol: Its Therapeutic Potential in Spinal Muscular Atrophy
(Wiley, 2009)Spinal muscular atrophy is an autosomal recessive motor neuron disease that is caused by mutation of the survival motor neuron gene (SMN1) but all patients retain a nearly identical copy SMN2. The disease severity correlates ... -
Homology modeling andin silicodesign of novel and potential dual-acting inhibitors of human histone deacetylases HDAC5 and HDAC9 isozymes
(2020)Histone deacetylases (HDACs) are a group of enzymes that have prominent and crucial effect on various biological systems, mainly by their suppressive effect on transcription. Searching for inhibitors targeting their ... -
Homology modeling of human GABA-AT and devise some novel and potent inhibitors via computer-aided drug design techniques
(Taylor & Francis Inc, 2020)Gamma-aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5 '-phosphate (PLP)-dependent enzyme which degrades gamma-aminobutyric (GABA) in the brain. GABA is an important inhibitory neurotransmitter that plays ... -
Homology modeling of human histone deacetylase 10 and design of potential selective inhibitors
(Taylor & Francis Inc, 2019)Histone deacetylases (HDACs) are implicated in the pathology of various cancers, and their pharmacological blockade has proven to be promising in reversing the malignant phenotypes. However, lack of crystal structures of ... -
How an Inhibitor Bound to Subunit Interface Alters Triosephosphate Isomerase Dynamics
(Cell Press, 2015)The tunnel region at triosephosphate isomerase (TIM)'s dimer interface distant from its catalytic site is a target site for certain benzothiazole derivatives that inhibit TIM's catalytic activity in Trypanosoma cruzi the ... -
How people can become persuaded by weak messages presented by credible communicators: Not all sleeper effects are created equal
(Academic Press Inc Elsevier Science, 2017)The sleeper effect has been proposed to describe temporal changes in persuasion for messages associated with noncredible sources. The present research introduces a new kind of sleeper effect denoting increases in persuasion ... -
How to activate intuitive and reflective thinking in behavior research? A comprehensive examination of experimental techniques
(Springer, 2022)Experiments comparing intuitive and reflective decisions provide insights into the cognitive foundations of human behavior. However, the relative strengths and weaknesses of the frequently used experimental techniques for ... -
Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities
(Taylor & Francis Inc, 2019)Parkinson's disease (PD) is characterized by the loss of dopamine-generating neurons in the substantia nigra and corpus striatum. Current treatments alleviate PD symptoms rather than exerting neuroprotective effect on ... -
Hyperuricemia in hypothyroidism: Is it associated with post-insulin infusion glycemic response?
(Tohoku Univ Medical Press, 2003)This experimental study was designed to examine whether hyperuricemia in hypothyroidism is associated with insulin resistance. For induction of hypothyroidism rabbits (n = 12) were administered methimazole orally (75 mg/100 ... -
Identification of Alternative Allosteric Sites in Glycolytic Enzymes for Potential Use as Species-Specific Drug Targets
(Frontiers Media, 2020)Three allosteric glycolytic enzymes, phosphofructokinase, glyceraldehyde-3 phosphate dehydrogenase and pyruvate kinase, associated with bacterial, parasitic and human species, were explored to identify potential allosteric ... -
Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and molecular dynamics studies
(Elsevier, 2020)Methionine Aminopeptidases MetAPs are divalent-cofactor dependent enzymes that are responsible for the cleavage of the initiator Methionine from the nascent polypeptides. MetAPs are classified into two isoforms: namely, ... -
Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening ADMET prediction and molecular dynamics simulation assay
(Taylor & Francis Inc, 2018)Histone deacetylases (HDACs) have gained increased attention as targets for anticancer drug design and development. HDAC inhibitors have proven to be effective for reversing the malignant phenotype in HDAC-dependent cancer ... -
The impact of the COVID-19 pandemic and behavioral restrictions on electricity consumption and the daily demand curve in Turkey
(Elsevier Sci Ltd, 2022)The rapid spread of COVID-19 has severely impacted many sectors, including the electricity sector. The reliability of the electricity sector is critical to the economy, health, and welfare of society; therefore, supply and ... -
Impacts of COVID-19 on changing patterns of household food consumption: An intercultural study of three countries
(Elsevier, 2021)In light of COVID-19's effects on individuals' social, economic, political, and psychological values, this paper aims to investigate the pandemic's role in possible changes to people's food consumption and meal habits in ... -
Improving performances of suboptimal greedy iterative biclustering heuristics via localization
(Oxford University Press, 2010)Motivation: Biclustering gene expression data is the problem of extracting submatrices of genes and conditions exhibiting significant correlation across both the rows and the columns of a data matrix of expression values. ... -
In silico identification of critical proteins associated with learning process and immune system for Down syndrome
(Public Library Science, 2019)Understanding expression levels of proteins and their interactions is a key factor to diagnose and explain the Down syndrome which can be considered as the most prevalent reason of intellectual disability in human beings. ... -
In silico identification of novel and selective monoamine oxidase B inhibitors
(SPRINGER WIEN, 2013)Monoamine oxidases (MAO) A and B are flavin adenine dinucleotides containing enzymes bound to the mitochondrial outer membranes of the cells of the brain liver intestine and placenta as well as platelets. Recently selective ... -
In situ split costal cartilage graft harvesting through a small incision using a gouge
(Lippincott Williams & Wilkins, 2000)A costal cartilage graft is one of the most useful materials in reconstructive plastic surgery. In this article a technique of in situ split costal cartilage graft harvesting through a small incision (2 to 3 cm) using a ...
