Browsing PubMed İndeksli Yayınlar Koleksiyonu by Title
Now showing items 176-195 of 378
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Identification of Alternative Allosteric Sites in Glycolytic Enzymes for Potential Use as Species-Specific Drug Targets
(Frontiers Media, 2020)Three allosteric glycolytic enzymes, phosphofructokinase, glyceraldehyde-3 phosphate dehydrogenase and pyruvate kinase, associated with bacterial, parasitic and human species, were explored to identify potential allosteric ... -
Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and molecular dynamics studies
(Elsevier, 2020)Methionine Aminopeptidases MetAPs are divalent-cofactor dependent enzymes that are responsible for the cleavage of the initiator Methionine from the nascent polypeptides. MetAPs are classified into two isoforms: namely, ... -
Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening ADMET prediction and molecular dynamics simulation assay
(Taylor & Francis Inc, 2018)Histone deacetylases (HDACs) have gained increased attention as targets for anticancer drug design and development. HDAC inhibitors have proven to be effective for reversing the malignant phenotype in HDAC-dependent cancer ... -
The impact of the COVID-19 pandemic and behavioral restrictions on electricity consumption and the daily demand curve in Turkey
(Elsevier Sci Ltd, 2022)The rapid spread of COVID-19 has severely impacted many sectors, including the electricity sector. The reliability of the electricity sector is critical to the economy, health, and welfare of society; therefore, supply and ... -
Impacts of COVID-19 on changing patterns of household food consumption: An intercultural study of three countries
(Elsevier, 2021)In light of COVID-19's effects on individuals' social, economic, political, and psychological values, this paper aims to investigate the pandemic's role in possible changes to people's food consumption and meal habits in ... -
Improving performances of suboptimal greedy iterative biclustering heuristics via localization
(Oxford University Press, 2010)Motivation: Biclustering gene expression data is the problem of extracting submatrices of genes and conditions exhibiting significant correlation across both the rows and the columns of a data matrix of expression values. ... -
In silico identification of critical proteins associated with learning process and immune system for Down syndrome
(Public Library Science, 2019)Understanding expression levels of proteins and their interactions is a key factor to diagnose and explain the Down syndrome which can be considered as the most prevalent reason of intellectual disability in human beings. ... -
In silico identification of novel and selective monoamine oxidase B inhibitors
(SPRINGER WIEN, 2013)Monoamine oxidases (MAO) A and B are flavin adenine dinucleotides containing enzymes bound to the mitochondrial outer membranes of the cells of the brain liver intestine and placenta as well as platelets. Recently selective ... -
In situ split costal cartilage graft harvesting through a small incision using a gouge
(Lippincott Williams & Wilkins, 2000)A costal cartilage graft is one of the most useful materials in reconstructive plastic surgery. In this article a technique of in situ split costal cartilage graft harvesting through a small incision (2 to 3 cm) using a ... -
An In-Depth Study on the Metabolite Profile and Biological Properties of Primula auriculata Extracts: A Fascinating Sparkle on the Way from Nature to Functional Applications
(Mdpi, 2022)The biological activity of the aerial part and rhizomes of Primula auriculata were assessed for the first time. The biological activities (antioxidant properties, enzyme inhibition, and AGE inhibition) as well as the ... -
The in-vivo assessment of Turkish propolis and its nano form on testicular damage induced by cisplatin
(Elsevier, 2021)Objective: Chemotherapeutic drugs, such as cisplatin (CP), which are associated with oxidative stress and apoptosis, may adversely affect the reproductive system. This study tests whether administration of propolis and ... -
Influence of cardiovascular risk factors on the outcome of coronary artery bypass surgery
(Springer Verlag, 2003)Purpose. To assess the impact of gender age and other cardiovascular risk factors on the outcomes of patients undergoing coronary artery bypass grafting (CABG). Methods. A total of 5 067 consecutive patients undergoing ... -
Influence of combined antioxidants against cadmium induced testicular damage
(Elsevier Science Bv, 2006)Acute effects ofcadmium (Cd) and combined antioxidants were evaluated in Sprague-Dawley rat testes. The rats were subdivided into four groups. Cadmium chloride (2 mg/kg day) injected intraperitoneally during 8 days. Vitamin ... -
Insights into the binding mode of new N-substituted pyrazoline derivatives to MAO-A: docking and quantum chemical calculations
(SPRINGER WIEN, 2013)The binding modes of four N-substituted pyrazoline derivatives as novel MAO-A inhibitory agents were investigated using docking and quantum chemical molecular modelling tools. -
An Integrated Molecular Communication System Based on Acoustic Tweezers
(IEEE-Inst Electrical Electronics Engineers Inc, 2023)In this work, a molecular communication link integrated with a micro-electro mechanical system (MEMS) based environment has been designed and simulated. The motivation behind this approach is to explore the possibility of ... -
Inter-trial effects in priming of pop-out: Comparison of computational updating models
(Public Library Science, 2021)In visual search tasks, repeating features or the position of the target results in faster response times. Such inter-trial 'priming' effects occur not just for repetitions from the immediately preceding trial but also ... -
The interrelationship between insulin secretion and action in Type 2 diabetes mellitus with different degrees of obesity: Evidence supporting central obesity
(Editrice Kurtis S R L, 2003)This paper investigates the relative role of the impairment of insulin secretion and action in the pathogenesis of Type 2 diabetes mellitus (T2DM). The parameters indicating insulin secretion and action were calculated ... -
Intraoperative saline-irrigated radiofrequency modified maze procedure for atrial fibrillation
(Elsevier Science Inc, 2002)Background. This study was conducted to evaluate the effectiveness of the saline-irrigated radiofrequency modified Maze operation for treatment of chronic atrial fibrillation and to compare the results of the left and ... -
Intraspinal metalloma resulting in late paraparesis
(Springer, 2005)The metal-related complications caused by orthopedic implants have long been a concern but these problems have been considered mostly in the field of arthroplasty or internal fixation of fractures. The recent prevalence ... -
Intravertebral vacuum phenomenon that developed during transpedicular biopsy
(W.B. Saunders Co Ltd, 2002)[Abstract Not Available]
