PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12469/4466

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Citation - WoS: 2
Jejunojejunal Intussusception Secondary To Lipoma in an Adult -: a Case Report
(Blackwell Munksgaard, 2002) Çakirer, S; Sirvanci, M; Duran, C
Lipoma is a rare cause of adult intussusception. We present the CT findings of an adult patient with jejunojejunal intussusception secondary to submucosal lipoma as the lead point in this case report.
Citation - Scopus: 1
Understanding the Dynamics of Compliance To Smoke-Free Policy Regulations: Exploring the Perspectives of Venue Owners and Staff in Türkiye
(European Publishing, 2024) Baltaci, Ezgi; Carkoglu, Asli; Saraf, Sejal; Ergueder, Toker; Ergoer, Guel; Hayran, Mutlu; Hoe, Connie
INTRODUCTION The study aims to understand the facilitators and barriers associated with enforcing and complying with Turkiye's smoke-free policy from the perspective of hospitality venue owners and employees. METHODS A qualitative open-ended survey was conducted in Istanbul and Ankara in 2021 with 58 respondents from 3 different districts in each city from four types of venues: restaurants, traditional coffee and waterpipe houses, and European-style cafes. The open-ended survey included questions to understand the knowledge, beliefs, and attitudes of respondents about Turkiye's smoke-free policy and their perceptions of the facilitators and/or barriers to smoke-free policy implementation and changes after COVID-19. The data were analyzed using an inductive approach to identify patterns and categorize the data into themes. RESULTS The respondents expressed that the smoke-free policy aimed to protect employees and customers from secondhand smoke (SHS), respect human health, and improve air quality. Findings suggest that the positive attitude of venue owners and staff toward the smoke-free policy serves as a facilitator. However, fear of financial impact, customers' negative attitudes, difficulties in meeting physical requirements, and insufficient enforcement were found to be barriers to implementing the smoke-free policy. The effects of the COVID-19 pandemic were reported as an initial increase in compliance and awareness among customers and staff, but some respondents noted negative changes due to the emotional and financial effects of prolonged restrictions. These challenges have led to decreased attention on the smoke-free policy among venue owners, staff and customers. Respondents' suggested improvements were related to building infrastructure, such as the ventilation systems and educating the public on the harmful health effects of smoking. CONCLUSIONS Despite the general understanding of the dangers of secondhand smoke and the smoke-free policy, this study highlights the challenges in implementing smoke-free policy measures and the continued need to raise awareness about the importance of a 100% smoke-free venue. A comprehensive approach to addressing the tobacco epidemic as a multifaceted public health issue is essential.
Citation - WoS: 1
Citation - Scopus: 1
Can Reflection Mitigate Covid-19 Vaccine Conspiracy Beliefs and Hesitancy
(Routledge, 2025) Bayrak, F.; Kayatepe, E.; Özman, N.; Yilmaz, O.; Isler, O.; Saribay, S.A.
Objective design: Periods of social turmoil, such as the COVID-19 pandemic, tend to amplify conspiracy beliefs, evidenced by increased vaccine hesitancy. Despite this trend, effective interventions targeting vaccine-related conspiracy beliefs remain scarce, partly due to underexplored cognitive processes. Three competing theoretical accounts offer differing predictions about the role of reflective thinking in supporting conspiracy beliefs: the Motivated Reasoning Account suggests reflection strengthens commitment to pre-existing attitudes; the Reflective Reasoning Account posits that reflection enhances belief accuracy; and the Reflective Doubt Account proposes reflection fosters general scepticism. Main outcome measures: Utilising open science practices and a validated technique to activate reflection, we conducted an experimental investigation with a diverse sample (N = 1483) segmented by vaccine attitudes. We investigated the impact of reflection on specific and generic COVID-19 conspiracy beliefs and vaccine-support behaviours across pro-vaccine, neutral, and vaccine-hesitant groups, while examining the moderating effects of scientific literacy, intellectual humility, and actively open-minded thinking. Results: The confirmatory analysis provided no direct support for the theoretical predictions. However, findings indicated that intellectual humility significantly moderated the effect of reflection, enhancing vaccine-support behaviour among participants with high intellectual humility, highlighting the complex interplay of cognitive style and prior attitudes in shaping responses to conspiracy beliefs and vaccine-support actions. Conclusion: The study highlights that while reflective thinking alone did not directly influence vaccine support behavior, its positive effect emerged among individuals with higher intellectual humility, emphasizing the importance of individual differences in shaping belief-related outcomes. © 2025 Informa UK Limited, trading as Taylor & Francis Group.
Citation - WoS: 1
Citation - Scopus: 1
Gamifying Haptics User Studies: Comparison of Response Times From Smartphone Interfaces
(IEEE Computer Soc, 2025) Kudsi, Bushra; Xu, Doris; Sen, Umit; Yoshida, Kyle T.; Stroppa, Fabio; Nunez, Cara M.; Sarac, Mine
Haptics user studies are often restricted to a set, physical location and use methods that do not captivate the user. Applying game design elements can create an entertaining environment and increase user engagement. Using ubiquitous tools, like smartphones, to conduct haptics user studies could allow researchers to access larger participant groups while a gamified approach could facilitate the data collection by making the experiment more enjoyable. To explore this concept, this work presents a gamified version of an existing psychophysical experiment that investigates response time to multisensory cues using a smartphone based on "Whac-A-Mole". We conducted a user study to compare our gamified interface with an existing psychophysical interface with thirteen participants exploring the response time from eighteen combinations of auditory, haptic, and visual stimuli at different levels of intensities and participant preferences for both interfaces. The results demonstrate that the gamified interface successfully captured similar trends in response times and significantly elevated participant enjoyment ($p < 0.003$), but did not result in equivalent response times to the original interface. This work shows the benefits and drawbacks of following a gamification approach when designing haptics user studies and discusses factors and trade-offs to consider when gamifying studies.
Citation - WoS: 1
Citation - Scopus: 2
Haptic Relocation Away From the Fingertip: Where, Why, and How
(IEEE Computer Soc, 2025) Sarac, Mine
Tactile haptic devices are often designed to render meaningful, complex, and realistic touch-based information on users' skin. While fingertips and hands are the most preferred body locations to render haptic feedback, recent trends allow such feedback to be extended to alternative body locations (e.g., wrist, arm, torso, foot) for various scenarios due to reasons such as wearability and needs of the application. In this paper, I address the new concept of haptic relocation. It refers to scenarios in which the expected feedback is related to the fingertips but rendered on a different body location instead - e.g., contact forces registered by two robotic fingers during teleoperation rendered to the users' wrist instead of the fingers. I investigated the design choices of wearable haptic devices for haptic relocation concerning different body locations, targeted applications, and actuator selection. I discuss approaches and design choices from the literature by speculating on the possible reasons, and conclude the paper by highlighting some challenges and issues to be mindful of in the future. This paper will guide engineers and researchers in searching for alternative haptic rendering solutions - especially when fingers and hands are not available for haptic interaction.
Citation - WoS: 2
Citation - Scopus: 2
Interaction Between Varying Social Ties on Health: Perceived Partner Responsiveness and Institutional Trust
(John Wiley & Sons Ltd, 2024) Tosyali, Furkan; Harma, Mehmet
The interplay between different forms of social relationships, that is, perceived partner responsiveness and institutional trust, on subjective health evaluations was examined for the first time. There were 1241 respondents who had a romantic relationship. After adjusting for the covariates, findings suggested that greater perceived partner responsiveness and institutional trust led respondents to report better subjective health. The positive link between perceived partner responsiveness and subjective health was more pronounced among the respondents reporting a lower level of institutional trust. Such an interaction could be an indicator pointing out the compensatory role of close relationship dynamics. Given that finding, public health authorities and practitioners could be encouraged to be aware of the adaptive function of social ties on health and focus on maintaining the strength of intimate social ties and building trust between authority gradients. This suggestion could especially be adaptive not only during "normal" times but also during post-disaster circumstances (e.g., COVID-19).
Metabolic Syndrome and Coronary Heart Disease;
(2004) Türkoǧlu,Ç.
[No abstract available]
Narratives of Preterm and Full-Term Preschool-Aged Children: Analyses of Different Narrative Dimensions
(Wiley, 2025) Akkan, Ibrahim; Esmer, Seref Can; Dogan, Isil; Aktan-Erciyes, Asli; Demir-Lira, o. Ece; Goksun, Tilbe
Preterm birth increases the likelihood of early language and cognitive delays, but less is known about later aspects of language development, such as narrative generation. Narrative skills involve dimensions, such as linguistic and narrative complexity, and preterm (PT) and full-term (FT) children's narrative performances may vary across these dimensions. We investigated the role of neonatal status on the total number of words produced, linguistic complexity, and narrative complexity across two presentation modes: narrative generation while seeing pictures and narrative generation after watching an animated video. Seventy-one Turkish-reared preschool-aged children (31 PT [Mage = 48.70, SD = 1.53] and 40 FT [Mage = 48.83, SD = 1.63]) participated in the study. Despite having lower expressive vocabulary skills (assessed by a standardized task) than full-term children, preterm children performed comparably in both picture and animated video-stories, except PT children tended to produce longer narratives in the picture story, possibly due to the different demand characteristics of the tasks. Overall, our findings support the possibility of interacting factors that may help PT children overcome challenges in narrative development.
Citation - WoS: 2
Citation - Scopus: 3
Biocontrol Potential of Vibrio Maritimus Chitinase: Heterologous Expression and Insecticidal Activity Against Acanthoscelides Obtectus
(Elsevier, 2025) Dikbas, Neslihan; Tulek, Ahmet; Ucar, Sevda; Alim, Seyma; Servili, Burak; Pacal, Nurettin; Ercisli, Sezai
In this study, the chitinase gene from the marine bacterium Vibrio maritimus was heterologously expressed in Escherichia coli, purified via affinity chromatography and tested for its insecticidal activity against the storage pest Acanthoscelides obtectus. The recombinant VmChiA protein exhibited a molecular mass of similar to 60 kDa, with optimum activity observed at pH 6.0 and 40 degrees C. Enzyme kinetic analysis revealed a K-m value of 0.042 mM, V-max of 17.48 mu mol min(-1), k(cat) of 1.75 min(-1) and catalytic efficiency of 41.61 mM(-1) min(-1), respectively. Furthermore, a dose of 40 U mL(-1) of recombinant VmChiA showed similar efficacy to malathion insecticide against A. obtectus, with 100 % mortality in both treatments. LC50 and LC90 values of VmChiA were 13.95 U mL(-1) and 27.66 U mL(-1), respectively. Furthermore, the three-dimensional structure of the catalytic site of VmChiA was modeled. Molecular dynamics simulation technique was used to explore and analyze the dynamics and interactions. A salt bridge (GLU274-ARG296) in the alpha + beta domain was observed as a critical feature facilitating substrate (GlcNAc)(2) binding and enzymatic activity. These findings demonstrate that recombinant VmChiA possesses potent insecticidal properties, highlighting its potential as a bio-based, eco-friendly alternative for managing significant agricultural pests.
Does Your Love Lift Me Higher? A Direct Replication of the Energising Role of Secure Relationships
(John Wiley & Sons Ltd, 2025) Lagap, Adar Cem; Harma, Mehmet
Previous work has revealed that priming people with significant others increases feelings of security and energy, and in turn, boosts exploration motivations. In this preregistered study, we directly replicated Luke et al.'s (2012) Study 2 (N = 281). We found similar results as the replicated study regarding increased security feelings and exploration motivations on the self-report measures after the priming. However, we did not find any support for the increased energy feelings after the attachment security priming. In addition, contrary to Luke et al.'s (2012) results, energy feelings did not mediate the relationship between security priming and exploration motivations. A discussion of null findings, along with the limitations of self-reports and potential misinterpretation of the mediational analyses, follows. We also discuss possible future implications of the current findings.
Hands-On Docking With Molegro Virtual Docker
(Humana Press Inc., 2026) Dere, D.; Pehlivan, S.N.; da Silva, A.D.; de Azevedo Junior, W.F.
Molegro Virtual Docker (MVD) integrates state-of-the-art search algorithms and scoring functions dedicated to protein-ligand docking simulations. It implements differential evolution as a search engine and MolDock and Plants scores to calculate binding affinity. In this work, we describe a workflow focused on how to build regression models to predict the inhibition of cyclin-dependent kinase 2 (CDK2). We employ available structural and binding data to construct machine learning models to calculate CDK2 inhibition based on the atomic coordinates obtained through docking simulations performed with MVD. We present a hands-on approach to show how to integrate docking results and machine learning methods available at Scikit-Learn to build targeted scoring functions. Our regression models show superior predictive performance compared with classical scoring functions. All CDK2 datasets and Jupyter Notebooks discussed in this work are available at GitHub: https://github.com/azevedolab/docking#readme. We made the source code of the program SAnDReS 2.0 available at https://github.com/azevedolab/sandres. © 2025 Elsevier B.V., All rights reserved.
Citation - Scopus: 11
Beyond Sightseeing: How Can Tourism Affect Public/Global Health in Modern Society?
(University of Edinburgh, 2022) Wen,J.; Kozak,M.; Jiang,Y.
[No abstract available]
Reshaping Globular Dynamics of S. Aureus Pyruvate Kinase via Bond Restraints to Allosteric Sites
(Springer, 2025) Fidan, Vahap Gazi; Aydin, Dilvin; Yazgi, Irem; Akten, E. Demet
The global dynamics of pyruvate kinase were examined using molecular dynamics (MD) simulations to investigate the effects of allosteric inhibition through bond restraints applied at two key allosteric sites. The study employed the experimentally resolved structure of the enzyme complexed with the allosteric inhibitor IS-130 at the small C-C interface, serving as a reference for analyzing an additional, computationally predicted allosteric site at the large A-A interface. Simulations identified the B and CT domains as the most mobile regions, with bond restraints at either interface significantly reducing CT domain flexibility up to 9 & Aring; across all chains. Restraints at the C-C interface limited minimal global conformational sampling, whereas restraints at the A-A interface altered the dynamic profile without narrowing the sampled conformational space, suggesting distinct regulatory roles for each interface. Distance fluctuation analyses revealed enhanced interchain communication and reduced mobility near restrained sites, suggesting that these restraints reinforce allosteric inhibition by stabilizing otherwise flexible domains. Cross-correlation analysis showed a marked reduction in long-range residue-residue correspondence, especially under C-C restraints, indicating disrupted dynamic coordination essential for catalytic activity. Mutual information analysis, capturing both linear and non-linear dependencies, further supported these findings by showing a widespread loss of dynamic correspondence in positional fluctuations across the receptor upon restraint application. Notably, although the C-C interface has been experimentally linked to inhibition, these results suggest that the computationally predicted large A-A interface may also contribute to allosteric regulation. Together, these findings highlight the distributed and cooperative nature of allosteric control in pyruvate kinase.
Citation - Scopus: 6
Solidarity Tourism: a Pathway To Revitalising the Health of Vulnerable War-Affected Populations?
(University of Edinburgh, 2023) Wen,J.; Hu,F.; Zheng,D.; Phau,I.; Kozak,M.; Hou,H.; Wang,W.
[No abstract available]
Citation - WoS: 1
Citation - Scopus: 1
From 'Safe Haven' To 'zone of Precarity': Locating Istanbul Through the Perceptions and Everyday Urban Practices of Skilled Migrants
(Springernature, 2025) Tuncer, Ezgi
This article seeks to position Istanbul through the practices of everyday life of middle-class, skilled migrants from both the Global North and South and their perceptions of urban safety and precarity. It examines individuals' processes of migration to Turkey, revealing their initial impressions of Istanbul as a safe city of opportunities, and then analyses their everyday urban lives, highlighting hidden forms of precarity and discrimination. Through in-depth interviews with 45 women and 34 men-more than half of whom are North American and European-and participant observation in people's living environments and at various social events, I argue that Istanbul, while perceived as a 'safe haven' at first, becomes a 'zone of precarity' where most of the participants have experienced intersectional forms of precarity, latent patterns of discrimination, and insecurities that belie the common perception that skilled migrants are privileged. To substantiate this argument, this ethno-spatial study presents an analysis of qualitative data as well as an online subjective mapping of Istanbul, where perceptions of urban safety and spatial precarity are displayed through socio-spatial experiences encountered in neighbourhoods, workplaces, and public spaces.
Investigation and Development of Novel Synthetic Approaches for Synthesis of Euxanthone and Derived Dyes
(Royal Soc Chemistry, 2024) Cetin, M. Mustafa
The historical dye Indian yellow, derived from euxanthic acid formed from 1,7-dihydroxyxanthone (euxanthone) and methyl (tri-O-acetyl-alpha-d-glucopyranosyl bromide) uronate, has significantly influenced the art world due to its vibrant color and unique production process. Studying Indian yellow is important for its historical relevance and impact on various art forms, as well as the challenges in its synthetic production. Herein, this work investigates the synthesis of the two main components, a novel method for obtaining euxanthone, and attempts to produce euxanthic acid and Indian yellow. All key intermediates and desired compounds have successfully been synthesized with good to high isolated yields, and characterized using different analytical and spectroscopic techniques. A proposed mechanism for euxanthone synthesis via 2,6,2 ',5 '-tetramethoxybenzophenone formation is also offered. During this process, 2,7-dihydroxyxanthone has also been synthesized, revealing an equilibration reaction that produced three isomeric tetramethoxybenzophenones, confirmed by both GC/MS and NMR. Following the synthesis of euxanthone and clarification of the equilibration, the production of Indian yellow via euxanthic acid formation has further been explored.
Citation - WoS: 3
Citation - Scopus: 3
The Gtp-Tubulin Cap Is Not the Determinant of Microtubule End Stability in Cells
(Amer Soc Cell Biology, 2024) Cassidy,A.; Farmer,V.; Arpağ,G.; Zanic,M.
Microtubules are dynamic cytoskeletal polymers essential for cell division, motility, and intracellular transport. Microtubule dynamics are characterized by dynamic instability-the ability of individual microtubules to switch between phases of growth and shrinkage. Dynamic instability can be explained by the GTP-cap model, suggesting that a "cap" of GTP-tubulin subunits at the growing microtubule end has a stabilizing effect, protecting against microtubule catastrophe-the switch from growth to shrinkage. Although the GTP-cap is thought to protect the growing microtubule end, whether the GTP-cap size affects microtubule stability in cells is not known. Notably, microtubule end-binding proteins, EBs, recognize the nucleotide state of tubulin and display comet-like localization at growing microtubule ends, which can be used as a proxy for the GTP-cap. Here, we employ high spatiotemporal resolution imaging to compare the relationship between EB comet size and microtubule dynamics in interphase LLC-PK1 cells to that measured in vitro. Our data reveal that the GTP-cap size in cells scales with the microtubule growth rate in the same way as in vitro. However, we find that microtubule ends in cells can withstand transition to catastrophe even after the EB comet is lost. Thus, our findings suggest that the presence of the GTP-cap is not the determinant of microtubule end stability in cells.
Data from SymSPAN and OSPAN Working Memory Capacity Tasks in Online and Laboratory Settings
(Elsevier, 2025) Wereszczynski, Michal; Chwilka, Paulina; Smolka, Ewa; Ilczuk, Ewa; Oner, Sezin; Barzykowski, Krystian
The present dataset comprises the performance of adult participants on two experimental tasks designed to measure working memory capacity: the Symmetry Span (SymSPAN) and Operation Span (OSPAN) tasks. Initially, a large sample of 566 participants completed these tasks online. From this pool, a random subset of individuals representing low, medium, and high levels of working memory capacity were invited to participate in two laboratory sessions. In these sessions, spaced one week apart, participants completed the same tasks again. The dataset includes complete performance data from both tasks, along with demographic information such as participants' age and gender. This relatively large dataset offers valuable opportunities for exploratory research on working memory capacity, including analyses of its relative stability, variations over time and across testing environments, individual differences, and contributions to meta-analyses. (c) 2025 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Solar Photovoltaic Development in West Africa Will Face Million-Ton Waste Challenges, and Off-Grid Systems Will Dominate
(Amer Chemical Soc, 2025) Dong, Di; Emem, Onis; Liu, Litao; Sen, Burak; Rasmussen, Kasper; Edomah, Norbert; Liu, Gang
Solar photovoltaic (PV), especially off-grid systems, is a low-hanging fruit option among various renewable energy technology choices to address universal energy access, energy security, and climate challenges for vulnerable regions like West Africa. West Africa dominates in the uptake of solar PV solutions, while little attention has been paid to the potential PV waste generation. In this study, we developed a technology-specific, prospective material flow analysis model to investigate material stocks and flows of both on-grid and off-grid solar PV systems for 15 West African countries up to 2050. We show that the cumulative solar PV waste generation ranges from 2.3 to 7.8 million tons by 2050 in West Africa under different scenarios, around 70% of which comes from off-grid PV systems. The potential secondary materials supply ranges from 213 to 704 kilotons, which have potential economic value amounting to 143-475 million dollars or material equivalent to produce 6-19 GW of solar PV capacity. These results call for urgent policy attention, technology development, and infrastructure investment for future PV waste management and highlight the significance of addressing off-grid PV waste in Africa.
Citation - WoS: 117
Citation - Scopus: 183
Opportunities and Challenges of Artificial Intelligence and Distributed Systems To Improve the Quality of Healthcare Service
(Elsevier, 2024) Aminizadeh, Sarina; Heidari, Arash; Dehghan, Mahshid; Toumaj, Shiva; Rezaei, Mahsa; Navimipour, Nima Jafari; Unal, Mehmet
The healthcare sector, characterized by vast datasets and many diseases, is pivotal in shaping community health and overall quality of life. Traditional healthcare methods, often characterized by limitations in disease prevention, predominantly react to illnesses after their onset rather than proactively averting them. The advent of Artificial Intelligence (AI) has ushered in a wave of transformative applications designed to enhance healthcare services, with Machine Learning (ML) as a noteworthy subset of AI. ML empowers computers to analyze extensive datasets, while Deep Learning (DL), a specific ML methodology, excels at extracting meaningful patterns from these data troves. Despite notable technological advancements in recent years, the full potential of these applications within medical contexts remains largely untapped, primarily due to the medical community's cautious stance toward novel technologies. The motivation of this paper lies in recognizing the pivotal role of the healthcare sector in community well-being and the necessity for a shift toward proactive healthcare approaches. To our knowledge, there is a notable absence of a comprehensive published review that delves into ML, DL and distributed systems, all aimed at elevating the Quality of Service (QoS) in healthcare. This study seeks to bridge this gap by presenting a systematic and organized review of prevailing ML, DL, and distributed system algorithms as applied in healthcare settings. Within our work, we outline key challenges that both current and future developers may encounter, with a particular focus on aspects such as approach, data utilization, strategy, and development processes. Our study findings reveal that the Internet of Things (IoT) stands out as the most frequently utilized platform (44.3 %), with disease diagnosis emerging as the predominant healthcare application (47.8 %). Notably, discussions center significantly on the prevention and identification of cardiovascular diseases (29.2 %). The studies under examination employ a diverse range of ML and DL methods, along with distributed systems, with Convolutional Neural Networks (CNNs) being the most commonly used (16.7 %), followed by Long Short -Term Memory (LSTM) networks (14.6 %) and shallow learning networks (12.5 %). In evaluating QoS, the predominant emphasis revolves around the accuracy parameter (80 %). This study highlights how ML, DL, and distributed systems reshape healthcare. It contributes to advancing healthcare quality, bridging the gap between technology and medical adoption, and benefiting practitioners and patients.

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