PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://gcris.khas.edu.tr/handle/20.500.12469/4466

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Citation Count: 0
The acquisition and use of relative clauses in Turkish-learning children's conversational interactions: a cross-linguistic approach (vol 46, pg 1142, 2019)
(Cambridge Univ Press, 2022) Uzundag, Berna A.; Kuntay, Aylin C.
[Abstract Not Available]
Citation Count: 40
Air quality prediction using CNN plus LSTM-based hybrid deep learning architecture
(Springer Heidelberg, 2022) Özmen, Atilla; Ogrenci, Arif Selcuk; Ozmen, Atilla
Air pollution prediction based on variables in environmental monitoring data gains further importance with increasing concerns about climate change and the sustainability of cities. Modeling of the complex relationships between these variables by sophisticated methods in machine learning is a promising field. The objectives of this work are to develop a supervised model for the prediction of air pollution by using real sensor data and to transfer the model between cities. The combination of a convolutional neural network and a long short-term memory deep neural network model was proposed to predict the concentration of air pollutants in multiple locations of a city by using spatial-temporal relationships. Two approaches have been adopted: the univariate model contains the information of one pollutant whereas the multivariate model contains the information of all pollutants and meteorology data for prediction. The study was carried out for different pollutants which are in the publicly available data of the cities of Barcelona, Kocaeli, and Istanbul. The hyperparameters of the model (filter, frame, and batch sizes; number of convolutional/LSTM layers and hidden units; learning rate; and parameters for sample selection, pooling, and validation) were tuned to determine the architecture that achieved the lowest test error. The proposed model improved the prediction performance (measured by the root mean square error) by 11-53% for particulate matter, 20-31% for ozone, 9-47% for nitrogenoxides, and 18-46% for sulfurdioxide with respect to the 1-hidden layer long short-term memory networks utilized in the literature. The multivariate model without using meteorological data revealed the best results. Regarding transfer learning, the network weights were transferred from the source city to the target city. The model has more accurate prediction performance with the transfer of the network from Kocaeli to Istanbul as those neighbor cities have similar air pollution and meteorological characteristics.
Citation Count: 2
Altered Dynamics of S. aureus Phosphofructokinase via Bond Restraints at Two Distinct Allosteric Binding Sites
(Academic Press Ltd- Elsevier Science Ltd, 2022) Akdoğan, Ebru Demet; Akten, Ebru Demet
The effect of perturbation at the allosteric site was investigated through several replicas of molecular dynamics (MD) simulations conducted on bacterial phosphofructokinase (SaPFK). In our previous work, an alternative binding site was estimated to be allosteric in addition to the experimentally reported one. To highlight the effect of both allosteric sites on receptor's dynamics, MD runs were carried out on apo forms with and without perturbation. Perturbation was achieved via incorporating multiple bond restraints for residue pairs located at the allosteric site. Restraints applied to the predicted site caused one dimer to stiffen, whereas an increase in mobility was detected in the same dimer when the experimentally resolved site was restrained. Fluctuations in C-alpha-C-alpha distances which is used to disclose residues with high potential of communication indicated a marked increase in signal transmission within each dimer as the receptor switched to a restrained state. Cross-correlation of positional fluctuations indicated an overall decrease in the magnitude of both positive and negative correlations when restraints were employed on the predicted allosteric site whereas an exact opposite effect was observed for the reported site. Finally, mutual correspondence between positional fluctuations noticeably increased with restraints on predicted allosteric site, whereas an opposite effect was observed for restraints applied on experimentally reported one. In view of these findings, it is clear that the perturbation of either one of two allosteric sites effected the dynamics of the receptor with a distinct and contrasting character. (c) 2022 Elsevier Ltd. All rights reserved.
Citation Count: 0
Analogy is Indispensable but Rule is a Must: Insights From Turkish
(Cambridge Univ Press, 2022) Nakipoglu, Mine; Uzundag, Berna A.; Ketrez, F. Nihan
Inflectional morphology provides a unique platform for a discussion of whether morphological productivity is rule-based or analogy-based. The present study testing 140 children (range = 29 to 97 months; M(SD) = 64.1(18.8)) on an elicited production task investigated the acquisition of the irregular distribution in the Turkish aorist. Results suggested that to discover the allomorphs of the Turkish aorist, children initially carried out similarity comparisons between analogous exemplars, which helped them tap into phonological features to induce generalizations for regulars and irregulars. Thereafter to tackle the irregularity, children entertained competing hypotheses yielding overregularizations and irregularizations. While the trajectory of overregularizations implicated the gradual formulation of an abstraction based on type-frequency, irregularizations suggested both intrusion of analogous exemplars and children's attempts to default to an erroneous micro-generalization. Our findings supported a model of morphological learning that is driven by analogy at the outset and that invokes rule-induction in later stages.
Citation Count: 1
Anomalous pancreaticobiliary junction (APBJ) with the drainage of the uncinate process into the minor papilla: demonstration by MRI
(BRITISH INST RADIOLOGY, 2005) Başaranoğlu, Metin; Balcı, Numan Cem; Kloer, Hans Ulrich
We report a case of a 30-year-old patient with anomalous pancreaticobiliary junction (APBJ) that has not been described before. The patient had a clinical history of recurrent attacks of pancreatitis cholangitis and cholecystitis that were confirmed by abnormal laboratory values. Endoscopic retrograde cholangiopancreatography revealed a 20 mm long junction of choledoc and pancreatic duct and uncinate process draining into the minor papilla. On MR cholangiopancreatography strictures at the junction of hepatic duct increased gallbladder wall thickness and intraductal stone in the pancreatic duct were demonstrated as complementary findings. Other MRI findings included decreased signal intensity of the pancreas consistent with fibrosis from past pancreatitis attacks and atrophy of the left liver lobe.
Citation Count: 9
Anterior instrumentation for adolescent idiopathic scoliosis
(Springer Verlag, 2001) Göğüş, Abdullah; Talu, Ufuk; Akman, Sümeyra; Sar, Can; Hamzaoğlu, Azmi; Eralp, Levent
Thirty-two patients with adolescent idiopathic scoliosis underwent anterior fusion with rigid single rod (third generation instrumentation) and titanium mesh cages. The mean follow-up was 31 (24-45) months and the mean age was 14.9 years. There were 8 patients with King type I 10 with type II 6 with type III 4 with type IV and 4 with lumbar curves. Titanium mesh cages were used in all the lumbar procedures and at the cranial and caudal ends of the instrumented area in thoracic cases. All the patients were immobilized in an orthosis for 3-6 months postoperatively. Mean preoperative primary coronal Cobb angle of 56 degrees was improved to 8.6 degrees. Average correction rate was 84%. Sagittal balance was restored with a mean thoracic kyphosis of 28 degrees and a mean lumbar lordosis of 38 degrees. Spontaneous secondary curve decompensation did not occur and postoperative thoracolumbar junctional kyphosis was not seen. One case had to be revised due to proximal screw pull out and loss of correction.
Citation Count: 1
Assessing protein-ligand binding modes with computational tools: the case of PDE4B
(Springer, 2017) Akdoğan, Ebru Demet; Aviyente, Viktorya; Akten, Ebru Demet; Monard, Gerald
In a first step in the discovery of novel potent inhibitor structures for the PDE4B family with limited side effects we present a protocol to rank newly designed molecules through the estimation of their IC values. Our protocol is based on reproducing the linear relationship between the logarithm of experimental IC values [(IC)] and their calculated binding free energies (). From 13 known PDE4B inhibitors we show here that (1) binding free energies obtained after a docking process by AutoDock are not accurate enough to reproduce this linear relationship
Citation Count: 6
Attachment anxiety benefits from security priming: Evidence from working memory performance
(Public Library Science, 2018) Gökçe, Ahu; Harma, Mehmet
The present study investigates the relationship between the attachment dimensions (anxious vs. avoidance) and the cognitive performance of individuals specifically whether the attachment dimensions would predict the working memory (WM) performance. In the n-back task reflecting the WM capacity both attachment related and non-attachment related words were used. Participants were randomly assigned into two groups that received either the secure or the neutral subliminal priming. In the secure priming condition the aim was to induce sense of security by presenting secure attachment words prior to the n-back task performance. In neutral priming condition neutral words that did not elicit sense of security were presented. Structural equation modeling revealed divergent patterns for attachment anxiety and avoidance dimensions under the different priming conditions. In neutral priming condition WM performance declined in terms of capacity in the n-back task for individuals who rated higher levels of attachment anxiety. However in the secure priming condition WM performance was boosted in the n-back task for individuals who rated higher levels of attachment anxiety. In other words the subliminal priming of the security led to increased WM capacity of individuals who rated higher levels of attachment anxiety. This effect however was not observed for higher levels of attachment avoidance. Results are discussed along the lines of hyperactivation and deactivation strategies of the attachment system.
Citation Count: 19
The availability of abortion at state hospitals in Turkey: A national study
(Elsevier, 2017) Louıse Şimşek, Mary
Introduction: Abortion in Turkey has been legal since 1983 and remains so today. Despite this in 2012 the Prime Minister declared that in his opinion abortion was murder. Since then there has been growing evidence that abortion access particularly in state hospitals is being restricted although no new legislation has been offered. Objectives: The study aimed to determine the number of state hospitals in Turkey that provide abortions. Study design: The study employed a telephone survey in 2015-2016 where 431 state hospitals were contacted and asked a set of questions by a mystery patient. If possible information was obtained directly from the obstetrics/gynecology department. I removed specialist hospitals from the data set and the remaining data were analyzed for frequency and cross-tabulations were performed. Results: Only 7.8% of state hospitals provide abortion services without regard to reason which is provided for by the current law while 78% provide abortions when there is a medical necessity. Of the 58 teaching and research hospitals in Turkey 9 (15.5%) provide abortion care without restriction to reason 38 (65.5%) will do the procedure if there is a medical necessity and 11 (11.4%) of these hospitals refuse to provide abortion services under any circumstances. There are two regions encompassing 1.5 million women of childbearing age where no state hospital provides for abortion without restriction as to reason. Conclusion: The vast majority of state hospitals only provide abortions in the narrow context of a medical necessity and thus are not implementing the law to its full extent. It is clear that although no new legislation restricting abortion has been enacted state hospitals are reducing the provision of abortion services without restriction as to reason. Implications: This is the only nationwide study to focus on abortion provision at state hospitals. (C) 2017 Elsevier Inc. All rights reserved.
Citation Count: 3
The availability of emergency contraception from family health centers in Turkey
(Elsevier Ireland Ltd, 2022) Louıse Şimşek, Mary; Aldanmaz, Bahar; Altuntas, Deniz
Reproductive health care, including contraception, is a fundamental aspect of any public health care system and it is important to reduce barriers to access to all forms of contraception, including emergency contraception. In recent years, the rhetoric of pronatalism in Turkey has come to dominate and raises questions about the availability of reproductive health care services, in particular contraception, from state run facilities. This study aimed to determine the availability of dedicated emergency contraception (EC) from government run Family Health Centers (FHCs) in Turkey. In 2019, a team of trained researchers called a random sample of 583 FHCs located in the largest cities in twelve regions across Turkey asking for dedicated EC. Dedicated EC is largely unavailable from government supported FHCs. Only 6.1% stated that they provided EC while 53.8% stated that it was not available and that they could provide no alternative. A further 28.3% declared that they could provide an alternative to dedicated EC that almost always consisted of oral contraceptives. We found statistically significant variations in response rate and availability among cities as well as the rate of referral to pharmacies. There is little access to EC from government sponsored health clinics designated to provide family planning services, which hinders access to an essential reproductive health care service that should be available to women everywhere.
Citation Count: 12
Blind Dockings of Benzothiazoles to Multiple Receptor Conformations of Triosephosphate Isomerase from Trypanosoma cruzi and Human
(Wiley-VCH Verlag GmbH, 2011) Akdoğan, Ebru Demet; Ural, Gulgun; Akten, Ebru Demet; Doruker, Pemra
We aim to uncover the binding modes of benzothiazoles which have been reported as specific inhibitors of triosephosphate isomerase from the parasite Trypanosoma cruzi (TcTIM) by performing blind dockings on both TcTIM and human TIM (hTIM). Detailed analysis of binding sites and specific interactions are carried out based on ensemble dockings to multiple receptor conformers obtained from molecular dynamics simulations. In TcTIM dimer dockings the inhibitors preferentially bind to the tunnel-shaped cavity formed at the interface of the subunits whereas non-inhibitors mostly choose other sites. In contrast TcTIM monomer binding interface and hTIM dimer interface do not present a specific binding site for the inhibitors. These findings point to the importance of the tunnel and of the dimeric form for inhibition of TcTIM. Specific interactions of the inhibitors and their sulfonate-free derivatives with the receptor residues indicate the significance of sulfonate group for binding affinity and positioning on the TcTIM dimer interface. One of the inhibitors also binds to the active site which may explain its relatively higher inhibition effect on hTIM.
Citation Count: 2
Captain or deckhand? The impact of self-leadership on employees' work role performance under remote work
(Frontiers Media Sa, 2022) Maden-Eyiusta, Ceyda; Alparslan, Suzan Ece
Relying on self-determination theory, this study investigates the mediating role of psychological empowerment in the relationship between self-leadership and work role performance (task proficiency, task adaptivity, and task proactivity) in remote work settings. It also explores whether and how supervisor close monitoring moderates the indirect impact of self-leadership on work role performance. Hypotheses were tested using a two-study design including white-collar employees from a broad range of jobs and companies (Study 1) and employee-supervisor dyads working in small and medium-sized firms (Study 2) in Turkey. In Study 1, results showed that self-leadership had a positive indirect effect on employees' work role performance through psychological empowerment. In Study 2, the cross-lagged two-wave design provided support for this indirect effect while demonstrating partial support for the moderating role of supervisor close monitoring. The current study contributes to research on self-leadership and work role performance by providing a detailed understanding of the motivational process through which self-leadership leads to increased work role performance. It also offers practical insights for enhancing self-leaders' work role performance, particularly within the remote work context.
Citation Count: 0
Children's questions and teachers' responses about COVID-19 in Türkiye and the US
(Public Library Science, 2024) Unlutabak, Burcu; Trujillo Hernandez, Graciela; Velioglu, Ilayda; Menendez, David; Rosengren, Karl S.
Question-asking is a crucial tool for acquiring information about unseen entities, such as viruses; thus, examining children's questions within the context of COVID-19 is particularly important for understanding children's learning about the coronavirus. The study examined 3-12-year-old children's questions and teachers' responses about the COVID-19 pandemic in T & uuml;rkiye, a non-Western developing context, and the United States, a Western cultural context. A total of 119 teachers from T & uuml;rkiye and 95 teachers from the US participated in the study. Teachers completed an online survey consisting of a demographic form and a questionnaire asking them to report three questions about COVID-19 asked by children in their classrooms and their responses to these questions. We analyzed children's questions and teachers' responses for their type and content and examined demographic factors associated with children's questions and teachers' responses. Consistent with the literature, children from T & uuml;rkiye asked fewer explanation-seeking (i.e., why/how) questions than children from the United States. Children asked questions about viruses and precautions. Teachers responded to children's questions realistically in both countries. The findings have important implications for how children gain knowledge from teachers when discussing health, disease, and virus topics in two countries.
Citation Count: 0
Decoding cultural conflicts
(Frontiers Media Sa, 2023) Yegin, Afşar; Puranam, Phanish; Yegin, Afsar
As pioneers of the Carnegie Perspective recognized, conflicts in organizations can exist even when incentives of all parties are aligned. These can often be traced to differences in cognitions such as beliefs and values, which are foundational components of any given culture. This paper refines the operationalization of cultural clashes by identifying differences in beliefs about causality (which actions cause which outcomes) and morality (in the broad sense of what is evaluated as desirable) as two fundamental sources of conflict. In our first study, we demonstrate empirically that participants recognize and distinguish between these two sources of conflict. In our second study, we test the hypotheses that while misalignments in either causal or moral codes increase observers' perceptions of relationship conflict, negative affect, likelihood of avoidance, and lower perceived likelihood of conflict resolution, the effects are stronger for misalignments in moral codes than misalignments in causal codes and strongest when both causal and moral codes are misaligned. We test these arguments using vignette-based experimental studies. Our findings support our hypotheses. This research has significant implications for the understanding of conflict dynamics within and beyond organizational contexts. By recognizing the pivotal role of cultural differences in shaping conflicts, organizations and decision-makers can better anticipate, manage, and potentially preempt such conflicts.
Citation Count: 2
Decrease in Staphylococcus aureus surgical site infections following cardiovascular surgery
(W.B. Saunders Co Ltd, 2005) Coşkun, Diler; Aytaç, Jale
[Abstract Not Available]
Citation Count: 13
Decrease in Staphylococcus aureus surgical-site infection rates after orthopaedic surgery after intranasal mupirocin ointment
(W B Saunders Co Ltd, 2004) Coskun, D; Aytac, J
[Abstract Not Available]
Citation Count: 7
Direct Bullying and Cyberbullying: Experimental Study of Bystanders' Motivation to Defend Victims and the Role of Anxiety and Identification With the Bully
(FRONTIERS MEDIA SA, 2021-01) Jungert, Tomas; Karataş, Pınar; Iotti, Nathalie Ophelia; Perrin, Sean
School bullying among young adolescents is a globally pervasive problem, but is less common when bystanders are motivated to defend victims. Thus, the focus of this experimental study is on motivation to defend victims of bullying. Methods: A total of 388 students (M (age) = 12.22 years, 49.7% girls) from two Turkish public schools (5th-8th grade) participated in a vignette experiment. Students were randomized to one of two vignettes (direct vs. cyberbullying). Self-report measures of motivation to defend, trait anxiety, depression, and identification with the victim or bully were used. Results: Participants reported more autonomous motivation in the cyberbullying condition, while those who witnessed direct bullying reported higher anxiety and depression. Results also revealed that this type of condition was associated with anxiety and depression, while anxiety was associated with autonomous motivation to defend. Finally, participants in the direct bullying condition were more likely to identify with the bully. Conclusion: Findings advance our understanding of when and why adolescents are motivated to help victims of bullying because they give a richer picture of what they assess when deciding whether or not they should intervene.
Citation Count: 5
Distinctive communication networks in inactive states of beta(2)-adrenergic receptor: Mutual information and entropy transfer analysis
(Wiley, 2020) Söğünmez Erdoğan, Nuray; Akdoğan, Ebru Demet
Mutual information and entropy transfer analysis employed on two inactive states of human beta-2 adrenergic receptor (beta(2)-AR) unraveled distinct communication pathways. Previously, a so-called "highly" inactive state of the receptor was observed during 1.5 microsecond long molecular dynamics simulation where the largest intracellular loop (ICL3) was swiftly packed onto the G-protein binding cavity, becoming entirely inaccessible. Mutual information quantifying the degree of correspondence between backbone-C(alpha)fluctuations was mostly shared between intra- and extra-cellular loop regions in the original inactive state, but shifted to entirely different regions in this latest inactive state. Interestingly, the largest amount of mutual information was always shared among the mobile regions. Irrespective of the conformational state, polar residues always contributed more to mutual information than hydrophobic residues, and also the number of polar-polar residue pairs shared the highest degree of mutual information compared to those incorporating hydrophobic residues. Entropy transfer, quantifying the correspondence between backbone-C(alpha)fluctuations at different timesteps, revealed a distinctive pathway directed from the extracellular site toward intracellular portions in this recently exposed inactive state for which the direction of information flow was the reverse of that observed in the original inactive state where the mobile ICL3 and its intracellular surroundings drove the future fluctuations of extracellular regions.
Citation Count: 0
Do autistic adults spontaneously reason about belief? A detailed exploration of alternative explanations
(Royal Soc, 2024) Wu, Ruihan; Lim, Jing Tian; Ahmed, Zahra; Berger, Rachael; Acem, Ensar; Chowdhury, Ishita; White, Sarah J.
Southgate et al.'s (Southgate 2007 Psychol. Sci. 18, 587-92 (doi:10.1111/j.1467-9280.2007.01944.x)) anticipatory-looking paradigm has presented exciting yet inconclusive evidence surrounding spontaneous mentalizing in autism. The present study aimed to develop this paradigm to address alternative explanations for the lack of predictive eye movements on false-belief tasks by autistic adults. This was achieved through implementing a multi-trial design with matched true-belief conditions, and both high and low inhibitory demand false-belief conditions. We also sought to inspect if any group differences were related to group-specific patterns of attention on key events. Autistic adults were compared with non-autistic adults on this adapted implicit mentalizing task and an established explicit task. The two groups performed equally well in the explicit task; however, autistic adults did not show anticipatory-looking behaviour in the false-belief trials of the implicit task. Critically, both groups showed the same attentional distribution in the implicit task prior to action prediction, indicating that autistic adults process information from social cues in the same way as non-autistic adults, but this information is not then used to update mental representations. Our findings further document that many autistic people struggle to spontaneously mentalize others' beliefs, and this non-verbal paradigm holds promise for use with a wide range of ages and abilities.
Citation Count: 2
Early parental causal language input predicts children's later causal verb understanding
(Cambridge Univ Press, 2023) Aktan-Erciyes, Asli; Goksun, Tilbe
How does parental causal input relate to children's later comprehension of causal verbs? Causal constructions in verbs differ across languages. Turkish has both lexical and morphological causatives. We asked whether (1) parental causal language input varied for different types of play (guided vs. free play), (2) early parental causal language input predicted children's causal verb understanding. Twenty-nine infants participated at three timepoints. Parents used lexical causatives more than morphological ones for guided-play for both timepoints, but for free-play, the same difference was only found at Time 2. For Time 3, children were tested on a verb comprehension and a vocabulary task. Morphological causative input, but not lexical causative input, during free-play predicted children's causal verb comprehension. For guided-play, the same relation did not hold. Findings suggest a role of specific types of causal input on children's understanding of causal verbs that are received in certain play contexts.

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