PubMed İndeksli Yayınlar Koleksiyonu
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Article Citation Count: 3Abortion services at hospitals in Istanbul(Taylor & Francis Ltd, 2017) Louıse Şimşek, MaryObjective: Despite the existence of a liberal law on abortion in Turkey there is growing evidence that actually securing an abortion in Istanbul may prove difficult. This study aimed to determine whether or not state hospitals and private hospitals that accept state health insurance in Istanbul are providing abortion services and for what indications. Method: Between October and December 2015 a mystery patient telephone survey of 154 hospitals 43 public and 111 private in Istanbul was conducted. Results: 14% of the state hospitals in Istanbul perform abortions without restriction as to reason provided in the current law while 60% provide the service if there is a medical necessity. A quarter of state hospitals in Istanbul do not provide abortion services at all. 48.6% of private hospitals that accept the state health insurance also provide for abortion without restriction while 10% do not provide abortion services under any circumstances. Key conclusions: State and private hospitals in Istanbul are not providing abortion services to the full extent allowed under the law. The low numbers of state hospitals offering abortions without restriction indicates a de facto privatization of the service. This same trend is also visible in many private hospitals partnering with the state that do not provide abortion care. While many women may choose a private provider the lack of provision of abortion care at state hospitals and those private hospitals working with the state leaves women little option but to purchase these services from private providers at some times subtantial costs.Article Citation Count: 10Antihepatitis B response to hepatitis B vaccine administered simultaneously with tetanus toxoid in nonresponder individuals(Elsevier Science, 2002) Sönmez, Emine; Sönmez, Ali Suha; Bayındır, Yaşar; Coşkun, Diler; Ariturk, SedatIn this prospective study our aim was to test the effect of simultaneous administration of preS2 and S containing recombinant hepatitis B vaccine (S2SRHB) with tetanus toxoid (TT) to the individuals who did not respond after three doses of hepatitis B vaccine previously. There were three groups (healthy individuals pregnant women hemodialysis patients) each was divided into two subgroups as groups A and B. Group A received S2SRHB + TT and group B received only S2SRHB. We found that in groups receiving both vaccines both seroconversion rate and antibody titer level were significantly higher (P < 0.05). In conclusion simultaneous administration of S2SRHB + TT is more effective than administration of S2SRHB alone. (C) 2002 Elsevier Science Ltd. All rights reserved.Article Citation Count: 7Apolipoprotein B gene variants are involved in the determination of blood glucose and lipid levels in patients with non-insulin dependent diabetes mellitus(Wiley, 2006) Duman, Belgin Süsleyici; Öztürk, Melek; Yilmazer, Selma; Çağatay, Penbe; Hatemi, HüsrevWe have examined the frequency of the EcoRI XbaI and MspI RFLPs of the apolipoprotein B (apo 13) gene in I 10 type 2 diabetic patients and 9 1 healthy control subjects in order to ascertain whether variation in this gene may influence the development of non-insulin dependent diabetes mellitus (type 2 diabetes). Serum lipids including total-cholesterol (T-Chol) triacylglycerol (TAG) apolipoprotein E (apo E) apolipoprotein Al (apo Al) apolipoprotein B and lipoprotein (a) (Lp(a)) were analysed. Genomic DNA was extracted and the apo B polymorphic regions amplified by the polymerase chain reaction. Regions carrying EcoRI XbaI and MspI restriction sites present in the apo B gene were amplified and digested separately by the respective enzymes. No significant difference for genotypic frequencies was observed for the EcoRI XbaI and MspI restriction sites in type 2 diabetic patients as compared to controls. Type 2 diabetic patients and controls with EcoRI +/+ and XbaI +/+ genotypes had higher apo E levels. The MspI +/+ genotype is more frequent in the patient and control groups With elevated T-Chol. Furthermore the EcoRI -/- XbaI -/- and MspI +/+ genotypes were found to be significantly more frequent in type 2 diabetic patients with higher blood glucose levels. This study identifies the apo B gene polymorphisms in modulating plasma lipid/lipoprotein and glucose levels in patients with type 2 diabetes. Copyright 0 2005 John Wiley & Sons Ltd.Article Citation Count: 0Background TV and infant-family interactions: Insights from home observations(Wiley, 2024) Uzundag, Berna A.; Koskulu-Sancar, Suemeyye; Kuntay, Aylin C.Background television has been found to negatively impact children's language development and self-regulatory skills, possibly due to decreased parent-child interactions. Most of the research on the relationship between background TV and caregiver-child interactions has been conducted in laboratory settings. In the current study, we conducted home observations and investigated whether infants engage in fewer interactions with family members in homes where background TV is more prevalent. We observed 32 infants at the ages of 8, 10, and 18 months in their home environments, coding for dyadic interactions (e.g., parent talking to and/or engaging with the child), triadic interactions (e.g., parent and infant play with a toy together), and infants' individual activities. Our findings revealed that background TV was negatively associated with the time infants spent in triadic interactions, positively associated with time spent engaging in individual activities, and not significantly related to the time spent in dyadic interactions. Apart from the relationship between background TV and individual activity time at 8 months, these associations remained significant even after accounting for families' socioeconomic status. These findings imply a correlation between background TV exposure and caregiver-infant-object interactions, warranting a longitudinal analysis with larger sample sizes.Article Citation Count: 14Collective remembering and future forecasting during the COVID-19 pandemic: How the impact of COVID-19 affected the themes and phenomenology of global and national memories across 15 countries(Springer, 2023) Oner, Sezin; Watson, Lynn Ann; Adiguzel, Zeynep; Ergen, Irem; Bilgin, Ezgi; Curci, Antonietta; Cole, ScottThe COVID-19 pandemic created a unique set of circumstances in which to investigate collective memory and future simulations of events reported during the onset of a potentially historic event. Between early April and late June 2020, we asked over 4,000 individuals from 15 countries across four continents to report on remarkable (a) national and (b) global events that (i) had happened since the first cases of COVID-19 were reported, and (ii) they expected to happen in the future. Whereas themes of infections, lockdown, and politics dominated global and national past events in most countries, themes of economy, a second wave, and lockdown dominated future events. The themes and phenomenological characteristics of the events differed based on contextual group factors. First, across all conditions, the event themes differed to a small yet significant degree depending on the severity of the pandemic and stringency of governmental response at the national level. Second, participants reported national events as less negative and more vivid than global events, and group differences in emotional valence were largest for future events. This research demonstrates that even during the early stages of the pandemic, themes relating to its onset and course were shared across many countries, thus providing preliminary evidence for the emergence of collective memories of this event as it was occurring. Current findings provide a profile of past and future collective events from the early stages of the ongoing pandemic, and factors accounting for the consistencies and differences in event representations across 15 countries are discussed.Article Citation Count: 2Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source Turkish DeLight(Tubitak Scientific & Technological Research Council Turkey, 2023) Atalay, Necati; Akcan, Enver Kamil; Gul, Mehmet; Ayan, Esra; Destan, Ebru; Ertem, Fatma Betuel; Tokay, NurettinX-ray crystallography is a robust and powerful structural biology technique that provides high-resolution atomic structures of biomacromolecules. Scientists use this technique to unravel mechanistic and structural details of biological macromolecules (e.g., proteins, nucleic acids, protein complexes, protein-nucleic acid complexes, or large biological compartments). Since its inception, single-crystal cryocrystallography has never been performed in Turkiye due to the lack of a single-crystal X-ray diffractometer. The X-ray diffraction facility recently established at the University of Health Sciences, Istanbul, Turkiye will enable Turkish and international researchers to easily perform high-resolution structural analysis of biomacromolecules from single crystals. Here, we describe the technical and practical outlook of a state-of-the-art home-source X-ray, using lysozyme as a model protein. The methods and practice described in this article can be applied to any biological sample for structural studies. Therefore, this article will be a valuable practical guide from sample preparation to data analysis.Article Citation Count: 3Cultural differences in performance on Eriksen's flanker task(Springer, 2020) Arslan Uzundağ, Berna; Ksander, John; Millar, Peter R.; Arslan Uzundağ, Berna; Sekuler, Robert; Boduroğlu, AyşecanEriksen's zoom model of attention implies a trade-off between the breadth and resolution of representations of information. Following this perspective, we used Eriksen's flanker task to investigate culture's influence on attentional allocation and attentional resolution. In Experiment1, the spatial distance of the flankers was varied to test whether people from Eastern cultures (here, Turks) experienced more interference than people from Western cultures (here, Americans) when flankers were further from the target. In Experiment2, the contrast of the flankers was varied. The pattern of results shows that congruency of the flankers (Experiment1) as well as the degree of contrast of the flankers compared with the target (Experiment2) interact with participants' cultural background to differentially influence accuracy or reaction times. In addition, we used evidence accumulation modeling to jointly consider measures of speed and accuracy. Results indicate that to make decisions in the Eriksen flanker task, Turks both accumulate evidence faster and require more evidence than Americans do. These cultural differences in visual attention and decision-making have implications for a wide variety of cognitive processes.Article Citation Count: 2DNA polymorphism of Pvu II site in the lipoprotein lipase gene in patients with non-insulin dependent diabetes mellitus(Wiley, 2005) Duman, Belgin Süsleyici; Öztürk, Melek; Yilmazer, Selma; Çağatay, Penbe; Hatemi, HüsrevWe studied the effect of variation at the lipoprotein lipase (LPL) gene locus on the susceptibility of individuals with non-insulin dependent diabetes mellitus (NIDDM) in a population of 110 NIDDM patients and 91 controls. Our objective was to study the relationship between the LPL-Pvu II polymorphism and NIDDM and lipid metabolism. PCR-RFLP was used to determine the DNA polymorphism of the sixth intron of the LPL gene. The frequencies of the genotypes in case and control groups were 29.1 and 30.8% for P+/P+Article Citation Count: 18Does normoxemic cardiopulmonary bypass prevent myocardial reoxygenation injury in cyanotic children?(W.B. Saunders Co Ltd, 2002) Bulutcu, Füsun S.; Bayındır, Osman; Polat, Bülent; Yalçın, Yalim; Özbek, Uğur; Cakali, EmineObjective: To evaluate whether the deleterious effect of cardiopulmonary bypass (CPB) can be prevented by controlling PaO2 in cyanotic children. Design: Prospective randomized clinical study. Setting: Single university hospital. Participants: Pediatric patients undergoing cardiac surgery for repair of congenital heart disease (n = 24). Interventions: Patients were randomly allocated into 3 groups. Patients in the acyanotic group (group I n = 10) had CPB initiated at a fraction of inspired oxygen (F1O2) of 1.0 (PO2 300 to 350 mmHg). Cyanotic patients were subdivided as follows: Group 11 (n = 7) had CPB initiated at an F1O2 of 1.0 and group III (n = 7) had CPB initiated at an F1O2 of 0.21 (PO2 90 to 110 mmHg). A biopsy specimen of right atrial tissue was removed during venous cannulation and another sample was removed after CPB before aortic cross-clamping. The tissue was incubated in 4 mmol/L of t-butylhydroperoxide and the malondialdehyde (MDA) level was measured to determine the antioxidant reserve capacity. Blood samples for cytokine levels tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 response to CPB were collected after induction of anesthesia and at the end of CPB before prolamine administration. Measurements and Main Results: After initiation of CPB MDA level rose markedly in the cyanotic groups compared with the acyanotic group (210 +/- 118% v 52 +/- 34% p < 0.05) which indicated the depletion of antioxidants. After initiation of CPB TNF-&alphaArticle Citation Count: 3Effect of the treatment of brucellosis on leukocyte superoxide dismutase activity and plasma nitric oxide level(Sage Publications Inc, 2005) Karabulut, Aysun Bay; Sönmez, Emine; Bayındır, YaşarBackground: The mechanisms by which brucellae evade intracellular killing by polymorphonuclear leukocytes are incompletely understood. In this study we evaluated changes of leukocyte superoxide dismutase (SOD) activity and plasma total nitrite as an indicator of nitric oxide (NO) levels during brucellosis therapy. Methods: Thirty-two patients with acute brucellosis 27 patients with chronic brucellosis and 30 healthy controls were included in the study. Patients with acute brucellosis were tested for leukocyte SOD activity and plasma total nitrite levels before during (21st day) and at the end (45th day) of the combined therapy of rifampicin and doxycycline. The same parameters were also investigated in chronic cases and controls. Results: The SOD activities were lower in patients with acute brucellosis before therapy compared with those 21 and 45 days after starting therapy (P < 0.001). In contrast total nitrite levels did not change significantly (P > 0.05). Conclusions: In the present study leukocyte SOD activity was found to be decreased in patients with acute brucellosis. Enzyme activity was increased by treatment finally reaching the activity of healthy controls. Using an antioxidant agent in addition to classical antimicrobial therapy for acute brucellosis might be a therapeutic approach.Article Citation Count: 3The effect of weekend curfews on epidemics: a Monte Carlo simulation(Tubitak Scientific & Technical Research Council Turkey, 2021) Berker, Ahmet Nihat; Berker, A. NihatThe ongoing COVID-19 pandemic is being responded with various methods, applying vaccines, experimental treatment options, total lockdowns or partial curfews. Weekend curfews are among the methods for reducing the number of infected persons, and this method is practically applied in some countries such as Turkey. In this study, the effect of weekend curfews on reducing the spread of a contagious disease, such as COVID-19, is modeled using a Monte Carlo algorithm with a hybrid lattice model. In the simulation setup, a fictional country with three towns and 26,610 citizens were used as a model. Results indicate that applying a weekend curfew reduces the ratio of ill cases from 0.23 to 0.15. The results also show that applying personal precautions such as social distancing is important for reducing the number of cases and deaths. If the probability of disease spread can be reduced to 0.1, in that case, the death ratio can be minimized down to 0.Article Citation Count: 4The effects of prolactin on the immune system, its relationship with the severity of COVID-19, and its potential immunomodulatory therapeutic effect(Academic Press Ltd- Elsevier Science Ltd, 2023) Rasmi, Yousef; Jalali, Ladan; Khalid, Saliha; Shokati, Ameneh; Tyagi, Poonam; Ozturk, Alpaslan; Nasimfar, AmirProlactin (PRL) is an endocrine hormone secreted by the anterior pituitary gland that has a variety of physiological effects, including milk production, immune system regulation, and anti-inflammatory effects. Elevated levels of PRL have been found in several viral infections, including 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), a viral pathogen that has recently spread worldwide. PRL production is increased in SARS-CoV2 infection. While PRL can trigger the production of proinflammatory cytokines, it also has several anti-inflammatory effects that can reduce hyperinflammation. The exact mechanism of PRL's contribution to the severity of COVID-19 is unknown. The purpose of this review is to discuss the interaction between PRL and SARS-CoV2 infection and its possible association with the severity of COVID-19.Article Citation Count: 2Evaluation of the Potential Therapeutic Properties of Liquidambar orientalis Oil(Wiley-v C H verlag Gmbh, 2023) Baloglu, Mehmet Cengiz; Yildiz Ozer, Lutfiye; Pirci, Buket; Zengin, Gokhan; Uba, Abdullahi Ibrahim; Altunoglu, Yasemin CelikLiquidambar orientalis Mill., commonly called the Anatolian sweetgum or Sigla tree, is endemic to southwestern Turkey. It has been historically significant in traditional medicine. In our research, we delved into the therapeutic attributes of its oil, emphasizing its antioxidant, antimicrobial, and antitumor properties. The primary chemical constituent of the gum is styrene, accounting for 78.5 %. The gum demonstrated antioxidant capabilities in several assays, including in 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2 '-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP). It displayed bactericidal actions against various gram-positive bacteria, such as Staphylococcus aureus, and gram-negative strains, including Escherichia coli. Additionally, the oil showcased potent antitumor effects against breast (MDA-MB-231), lung (A549), and prostate (PC3) cancer cell lines. These effects were found to be both time- and dose-dependent. L. orientalis Mill. oil showed the best antitumor activity against breast, lung, and prostate cancer cell lines after the 24 h and 48 h treatment. Its oil might induce autophagy in the PC3 prostate cancer cell line, whereas its cytotoxicity against MDA-MB-231 and A549 cancer cell lines might not be correlated with autophagy or apoptosis pathways. In conclusion, the oil from the Sigla tree offers promising therapeutic potential and warrants further exploration.Article Citation Count: 14Exploration of the binding pocket of histone deacetylases: the design of potent and isoform-selective inhibitors(Tübitak, 2017) Yelekçi, Kemal; Yelekçi, KemalHistone deacetylases (HDACs) are enzymes that act on histone proteins to remove the acetyl group and thereby regulate the chromatin state. HDACs act not only on histone protein but also nonhistone proteins that are key players in cellular processes such as the cell cycle, signal transduction, apoptosis, and more. “Classical” HDACs have been shown to be promising targets for anticancer drug design and development. However, the selectivity of HDAC inhibitors for HDAC isoforms remains the motivation of current research in this field. Here, we explored Class I HDACs and HDAC6 by sequence alignment and structural superimposition, catalytic channel extraction, and identification of critical residues involved in HDAC catalysis. Based on the general pharmacophore features of known HDAC inhibitors, we developed a library of compounds by scaffold hopping on a fragment hit identified via structurebased virtual screening of the molecular fragment library retrieved from the Otava database. Molecular docking assay revealed five of these compounds to have increased potency and selectivity for HDACs 1 and 2. Furthermore, their predicted absorption, distribution, metabolism, elimination, and toxicity (ADMET) properties were consistent with those of drug-like compounds. With further modelingbased and experimental investigations, we believe that these findings may offer additional potential HDAC inhibitors with improved selectivityArticle Citation Count: 12Financial Literacy among Turkish College Students: The Role of Formal Education, Learning Approaches, and Parental Teaching(Ammons Scientific Ltd, 2014) Selçuk, Elif Akben; Altıok-Yılmaz, AyşeThis study assessed financial literacy and its correlates among Turkish college students with special emphasis on the role of formal education learning approaches and parental influences. Financial literacy was measured by the College Student Financial Literacy Survey which assesses knowledge in four areas: general financial management saving and borrowing insurance and investing. 853 Turkish university students were administered the survey (416 men 437 women ; M age = 20.3 yr. SD = 0.6). The mean percentage of correct responses was 45% (SD = 12.8%). Regression results showed that formal finance education in college a deep approach to learning and direct financial teaching by parents were significantly associated with higher financial literacy scores.Article Citation Count: 1The flashbulb-like nature of memory for the first COVID-19 case and the impact of the emergency. A cross-national survey(Routledge Journals, Taylor & Francis Ltd, 2024) Lanciano, Tiziana; Alfeo, Federica; Curci, Antonietta; Marin, Claudia; D'Uggento, Angela Maria; Decarolis, Diletta; Zheng, JinFlashbulb memories (FBMs) refer to vivid and long-lasting autobiographical memories for the circumstances in which people learned of a shocking and consequential public event. A cross-national study across eleven countries aimed to investigate FBM formation following the first COVID-19 case news in each country and test the effect of pandemic-related variables on FBM. Participants had detailed memories of the date and others present when they heard the news, and had partially detailed memories of the place, activity, and news source. China had the highest FBM specificity. All countries considered the COVID-19 emergency as highly significant at both the individual and global level. The Classification and Regression Tree Analysis revealed that FBM specificity might be influenced by participants' age, subjective severity (assessment of COVID-19 impact in each country and relative to others), residing in an area with stringent COVID-19 protection measures, and expecting the pandemic effects. Hierarchical regression models demonstrated that age and subjective severity negatively predicted FBM specificity, whereas sex, pandemic impact expectedness, and rehearsal showed positive associations in the total sample. Subjective severity negatively affected FBM specificity in Turkey, whereas pandemic impact expectedness positively influenced FBM specificity in China and negatively in Denmark.Article Citation Count: 4Gesture use in L1-Turkish and L2-English: Evidence from emotional narrative retellings(Sage Publications Ltd, 2023) Özer, Demet; Ozer, Demet; Goksun, TilbeBilinguals tend to produce more co-speech hand gestures to compensate for reduced communicative proficiency when speaking in their L2. We here investigated L1-Turkish and L2-English speakers' gesture use in an emotional context. We specifically asked whether and how (1) speakers gestured differently while retelling L1 versus L2 and positive versus negative narratives and (2) gesture production during retellings was associated with speakers' later subjective emotional intensity ratings of those narratives. We asked 22 participants to read and then retell eight emotion-laden narratives (half positive, half negative; half Turkish, half English). We analysed gesture frequency during the entire retelling and during emotional speech only (i.e., gestures that co-occur with emotional phrases such as happy). Our results showed that participants produced more representational gestures in L2 than in L1; however, they used more representational gestures during emotional content in L1 than in L2. Participants also produced more co-emotional speech gestures when retelling negative than positive narratives, regardless of language, and more beat gestures co-occurring with emotional speech in negative narratives in L1. Furthermore, using more gestures when retelling a narrative was associated with increased emotional intensity ratings for narratives. Overall, these findings suggest that (1) bilinguals might use representational gestures to compensate for reduced linguistic proficiency in their L2, (2) speakers use more gestures to express negative emotional information, particularly during emotional speech, and (3) gesture production may enhance the encoding of emotional information, which subsequently leads to the intensification of emotion perception.Article Citation Count: 0The Gtp-Tubulin Cap Is Not the Determinant of Microtubule End Stability in Cells(Amer Soc Cell Biology, 2024) Cassidy, Anna; Farmer, Veronica; Arpa, Goker; Zanic, MarijaMicrotubules are dynamic cytoskeletal polymers essential for cell division, motility, and intracellular transport. Microtubule dynamics are characterized by dynamic instability-the ability of individual microtubules to switch between phases of growth and shrinkage. Dynamic instability can be explained by the GTP-cap model, suggesting that a "cap" of GTP-tubulin subunits at the growing microtubule end has a stabilizing effect, protecting against microtubule catastrophe-the switch from growth to shrinkage. Although the GTP-cap is thought to protect the growing microtubule end, whether the GTP-cap size affects microtubule stability in cells is not known. Notably, microtubule end-binding proteins, EBs, recognize the nucleotide state of tubulin and display comet-like localization at growing microtubule ends, which can be used as a proxy for the GTP-cap. Here, we employ high spatiotemporal resolution imaging to compare the relationship between EB comet size and microtubule dynamics in interphase LLC-PK1 cells to that measured in vitro. Our data reveal that the GTP-cap size in cells scales with the microtubule growth rate in the same way as in vitro. However, we find that microtubule ends in cells can withstand transition to catastrophe even after the EB comet is lost. Thus, our findings suggest that the presence of the GTP-cap is not the determinant of microtubule end stability in cells.Article Citation Count: 9The impact of the COVID-19 pandemic and behavioral restrictions on electricity consumption and the daily demand curve in Turkey(Elsevier Sci Ltd, 2022) Bilge, Ayşe Hümeyra; Hekimoğlu, Mustafa; Yucekaya, A.; Bilge, A.; Aktunc, E. Agca; Hekimoglu, M.The rapid spread of COVID-19 has severely impacted many sectors, including the electricity sector. The reliability of the electricity sector is critical to the economy, health, and welfare of society; therefore, supply and demand need to be balanced in real-time, and the impact of unexpected factors should be analyzed. During the pandemic, behavioral restrictions such as lockdowns, closure of factories, schools, and shopping malls, and changing habits, such as shifted work and leisure hours at home, significantly affected the demand structure. In this research, the restrictions and their corresponding timing are classified and mapped with the Turkish electricity demand data to analyze the estimated impact of the restrictions on total demand and daily demand profile. A modulated Fourier Series Expansion evaluates deviations from normal conditions in the aggregate demand and the daily consumption profile. The aggregate demand shows a significant decrease in the early phase of the pandemic, during the period March-June 2020. The shape of the daily demand curve is analyzed to estimate how much demand shifted from daytime to night-time. A population-based restriction index is proposed to analyze the relationship between the strength and coverage of the restrictions and the total demand. The persistency of the changes in the daily demand curve in the post-contingency period is analyzed. These findings imply that new scheduling approaches for daily and weekly loads are required to avoid supply-demand mismatches in the future. The longterm policy implications for the energy transition and lessons learned from the COVID-19 pandemic experience are also presented.Article Citation Count: 0An Integrated Molecular Communication System Based on Acoustic Tweezers(IEEE-Inst Electrical Electronics Engineers Inc, 2023) Baykaş, Tunçer; Pusane, Ali Emre; Baykas, TuncerIn this work, a molecular communication link integrated with a micro-electro mechanical system (MEMS) based environment has been designed and simulated. The motivation behind this approach is to explore the possibility of merging acoustic tweezing technique with a molecular communication system to increase the accuracy and reliability of the overall communication link. The proposed design is simulated using finite element methods that mimic the actual environment for an accurate solution. We derive symbol error rate as a performance metric and further show that the proposed system outperforms the diffusion-based modulation techniques and facilitates a reliable communication in the presence of fluid flow and while being insusceptible to external factors.