Istıf, Emın
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Name Variants
Istıf, Emın
E.,Istıf
E. Istıf
Emın, Istıf
Istif, Emin
E.,Istif
E. Istif
Emin, Istif
E.,Istıf
E. Istıf
Emın, Istıf
Istif, Emin
E.,Istif
E. Istif
Emin, Istif
Job Title
Dr. Öğr. Üyesi
Email Address
Emın.ıstıf@khas.edu.tr
Main Affiliation
Molecular Biology and Genetics
Status
Former Staff
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Sustainable Development Goals Report Points
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Scholarly Output
12
Articles
10
Citation Count
0
Supervised Theses
0
12 results
Scholarly Output Search Results
Now showing 1 - 10 of 12
Article Citation - WoS: 1Citation - Scopus: 1Investigation of dynamic micromechanical properties of biodegradable elastic material by continuous stiffness measurement analysis(Sage Publications Ltd, 2023) Istıf, Emın; Istif, Emin; Bathaei, Mohammad Javad; Beker, Levent; Molecular Biology and GeneticsMicromechanical properties of polymeric materials play a critical role in various biological applications in terms of their biocompatibility and mechanical durability. Apart from material properties such as modulus and density, viscoelastic properties play a crucial role during the design and fabrication of devices. Here, we investigated the viscoelastic properties of poly (glycerol sebacate) (PGS), a widely used bioresorbable elastic material, through the nanoindentation technique, configured by the continuous stiffness measurement (CSM) method at frequencies from 10 Hz to 50 Hz. The results revealed that the storage modulus (E') depends on the test frequency and cannot be ignored as the results showed significant changes. Additionally, increasing the curing temperature of PGS specimens between 150 to 170 & DEG;C allows modifying the storage modulus of samples between 0.52 MPa and 1.05 MPa at 10 Hz. The results were also confirmed using the dynamic mechanical measurements to validate the reliability of the CSM nanoindentation technique.Article Citation - WoS: 42Citation - Scopus: 41Miniaturized Wireless Sensor Enables Real-Time Monitoring of Food Spoilage(Nature Portfolio, 2023) Istif, Emin; Istıf, Emın; Mirzajani, Hadi; Dag, Cagdas; Mirlou, Fariborz; Ozuaciksoz, Elif Yaren; Cakir, Cengiz; Koydemir, Hatice Ceylan; Molecular Biology and GeneticsFood spoilage results in food waste and food-borne diseases. Yet, standard laboratory tests to determine spoilage (mainly volatile biogenic amines) are not performed regularly by supply chain personnel or end customers. Here we developed a poly(styrene-co-maleic anhydride)-based, miniature (2 x 2 cm(2)) sensor for on-demand spoilage analysis via mobile phones. To demonstrate a real-life application, the wireless sensor was embedded into packaged chicken and beef; consecutive readings from meat samples using the sensor under various storage conditions enabled the monitoring of spoilage. While samples stored at room temperature showed an almost 700% change in sensor response on the third day, those stored in the freezer resulted in an insignificant change in sensor output. The proposed low-cost, miniature wireless sensor nodes can be integrated into packaged foods, helping consumers and suppliers detect spoilage of protein-rich foods on demand, and ultimately preventing food waste and food-borne diseases. Standard tests to determine food spoilage are costly and time consuming. A poly(styrene-co-maleic anhydride)-based sensor offers a low-cost alternative that can be linked to mobile phones for real-time spoilage analysis. The device was tested on chicken and beef samples under various storage conditions.Article Citation - WoS: 0Citation - Scopus: 0Near-Infrared Triggered Degradation for Transient Electronics(Amer Chemical Soc, 2024) Istıf, Emın; Ali, Mohsin; Ozuaciksoz, Elif Yaren; Morova, Yagiz; Beker, Levent; Molecular Biology and GeneticsElectronics that disintegrate after stable operation present exciting opportunities for niche medical implant and consumer electronics applications. The disintegration of these devices can be initiated due to their medium conditions or triggered by external stimuli, which enables on-demand transition. An external stimulation method that can penetrate deep inside the body could revolutionize the use of transient electronics as implantable medical devices (IMDs), eliminating the need for secondary surgery to remove the IMDs. We report near-infrared (NIR) light-triggered transition of metastable cyclic poly-(phthalaldehyde) (cPPA) polymers. The transition of the encapsulation layer is achieved through the conversion of NIR light to heat, facilitated by bioresorbable metals, such as molybdenum (Mo). We reported a rapid degradation of cPPA encapsulation layer about 1 min, and the rate of degradation can be controlled by laser power and exposure time. This study offers a new approach for light triggerable transient electronics for IMDs due to the deep penetration depth of NIR light through to organs and tissues.Review Citation - WoS: 70Citation - Scopus: 80Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications(Wiley, 2023) Istıf, Emın; Bathaei, Mohammad Javad; Istif, Emin; Karimi, Seyed Nasir Hosseini; Beker, Levent; Molecular Biology and GeneticsRecent materials, microfabrication, and biotechnology improvements have introduced numerous exciting bioelectronic devices based on piezoelectric materials. There is an intriguing evolution from conventional unrecyclable materials to biodegradable, green, and biocompatible functional materials. As a fundamental electromechanical coupling material in numerous applications, novel piezoelectric materials with a feature of degradability and desired electrical and mechanical properties are being developed for future wearable and implantable bioelectronics. These bioelectronics can be easily integrated with biological systems for applications, including sensing physiological signals, diagnosing medical problems, opening the blood-brain barrier, and stimulating healing or tissue growth. Therefore, the generation of piezoelectricity from natural and synthetic bioresorbable polymers has drawn great attention in the research field. Herein, the significant and recent advancements in biodegradable piezoelectric materials, including natural and synthetic polymers, their principles, advanced applications, and challenges for medical uses, are reviewed thoroughly. The degradation methods of these piezoelectric materials through in vitro and in vivo studies are also investigated. These improvements in biodegradable piezoelectric materials and microsystems could enable new applications in the biomedical field. In the end, potential research opportunities regarding the practical applications are pointed out that might be significant for new materials research.Article Citation - WoS: 1Citation - Scopus: 1Microneedles With Interdigitated Electrodes for in Situ Impedimetric Vegf Sensing(Wiley, 2025) Istıf, Emın; Istif, Emin; Cebecioglu, Rumeysa; Ali, Mohsin; Atik, Yasin; Dag, Cagdas; Beker, Levent; Molecular Biology and GeneticsContinuous monitoring of protein biomarkers in interstitial fluid (ISF) is essential for improving patient care and outcomes. This study presents a novel electrochemical impedance spectroscopy (EIS) sensor utilizing microneedles (MNs) patterned with interdigitated electrodes for the detection of vascular endothelial growth factor (VEGF). The MNs, are fabricated from flexible polylactide (PLA) using a simple molding technique, followed by metal deposition with an interdigitated pattern to serve as a platform for the EIS sensor. After functionalization with anti-VEGF antibodies, impedance measurements are conducted to detect VEGF levels, demonstrating a significant change in impedance in response to varying concentrations of the target biomarker. The MNs can easily penetrate rat skin by hand, puncturing without mechanical breakage. This innovative approach enhances the sensitivity and specificity of biomarker detection and paves the way for continuous monitoring applications in diagnostics and preventative medicine.Article Citation - WoS: 41Citation - Scopus: 42Photolithography-Based Microfabrication of Biodegradable Flexible and Stretchable Sensors(Wiley-V C H Verlag Gmbh, 2023) Istıf, Emın; Singh, Rahul; Mirzajani, Hadi; Istif, Emin; Akhtar, Muhammad Junaid; Abbasiasl, Taher; Beker, Levent; Molecular Biology and GeneticsBiodegradable sensors based on integrating conductive layers with polymeric materials in flexible and stretchable forms have been established. However, the lack of a generalized microfabrication method results in large-sized, low spatial density, and low device yield compared to the silicon-based devices manufactured via batch-compatible microfabrication processes. Here, a batch fabrication-compatible photolithography-based microfabrication approach for biodegradable and highly miniaturized essential sensor components is presented on flexible and stretchable substrates. Up to 1600 devices are fabricated within a 1 cm(2) footprint and then the functionality of various biodegradable passive electrical components, mechanical sensors, and chemical sensors is demonstrated on flexible and stretchable substrates. The results are highly repeatable and consistent, proving the proposed method's high device yield and high-density potential. This simple, innovative, and robust fabrication recipe allows complete freedom over the applicability of various biodegradable materials with different properties toward the unique application of interests. The process offers a route to utilize standard micro-fabrication procedures toward scalable fabrication of highly miniaturized flexible and stretchable transient sensors and electronics.Editorial Citation - WoS: 1A Low-Cost Wireless Miniaturized Device for Food Spoilage Monitoring(Nature Portfolio, 2023) Istif, Emin; Istıf, Emın; Beker, Levent; Molecular Biology and Genetics[Abstract Not Available]Article Citation - WoS: 17A Wearable Touch-Activated Device Integrated with Hollow Microneedles for Continuous Sampling and Sensing of Dermal Interstitial Fluid (Adv. Mater. 2/2024)(Wiley-v C H verlag Gmbh, 2024) Istıf, Emın; Mirlou, Fariborz; Mirzajani, Hadi; Bathaei, Mohammad Javad; Istif, Emin; Shomalizadeh, Narges; Beker, Levent; Molecular Biology and Genetics[No Abstract Available]Article Citation - WoS: 4Multicolor Photoluminescence from Nonconjugated Poly(3,4-dihydropyran) Nanoparticles(Amer Chemical Soc, 2023) Istıf, Emın; Bui, Anh Thy; Jonusauskas, Gediminas; McClenaghan, Nathan D.; Istif, Emin; Mantione, Daniele; Pavlopoulou, Eleni; Molecular Biology and GeneticsIn recent years, nonconjugated organic luminophores arereceivingconsiderable interest from the scientific community, offering a newconceptual basis for the development of alternative photoluminescence-basedtechnologies. In this work, the polymerization of 3,4-dihydropyranwas exploited for the preparation of nonconjugated photoluminescentpolymer nanoparticles. Remarkably, excitation-dependent multicoloremission ranging from blue to yellow was observed in both solid andsolution. In contrast with similar materials, this behavior was notattributed to aggregation-induced emission, but rather to the presenceof independent, noninteracting chromophores located on the polymerstructure. Structural and optical characterizations along with furtherchemical modifications suggest that the emission is related to thepresence of acetal groups formed by ring-opening polymerization. Inaddition, it was shown that the removal of unsaturated structurescould enhance the photoluminescence quantum yield of the polymer (QY)up to 0.20 (lambda(ex) = 355 nm). This work provides a newtype of nonconjugated organic luminophore with both high QY and multicoloremission.Article Citation - WoS: 3Citation - Scopus: 2Paper Integrated Microfluidic Contact Lens for Colorimetric Glucose Detection(Royal Soc Chemistry, 2024) Isgor, Pelin Kubra; Istıf, Emın; Abbasiasl, Taher; Das, Ritu; Istif, Emin; Yener, Umut Can; Beker, Levent; Molecular Biology and GeneticsContact lenses offer a simple, cost-effective, and non-invasive method for in situ real-time analysis of various biomarkers. Electro-chemical sensors are integrated into contact lenses for analysis of various biomarkers. However, they suffer from rigid electronic components and connections, leading to eye irritation and biomarker concentration deviation. Here, a flexible and microfluidic integrated paper-based contact lens for colorimetric analysis of glucose was implemented. Facilitating a three-dimensional (3D) printer for lens fabrication eliminates cumbersome cleanroom processes and provides a simple, batch compatible process. Due to the capillary force of the filter paper, the sample was routed to detection chambers inside microchannels, and it allowed further colorimetric detection. The paper-embedded microfluidic contact lens successfully detects glucose down to 2 mM within similar to 10 s. The small dimension of the microfluidic system enables detection of glucose levels as low as 5 mu l. The results show the potential of the presented approach to analyze glucose concentration in a rapid manner. It is demonstrated that the fabricated contact lens can successfully detect glucose levels of diabetic patients. Contact lenses offer a simple, cost-effective, and non-invasive method for in situ real-time analysis of various biomarkers.
