Güven, Ebru Bilget
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Name Variants
E. Güven
Güven, E. B.
Güven, Ebru Bilget
Güven,E.B.
EBRU BILGET GÜVEN
Güven, E.
Ebru Bilget, Guven
Güven E.
GÜVEN, Ebru Bilget
Guven, Ebru Bilget
G., Ebru Bilget
Ebru Bilget GÜVEN
Guven,E.B.
GÜVEN, EBRU BILGET
Güven, EBRU BILGET
E. B. Güven
Guven,Ebru Bilget
G.,Ebru Bilget
Ebru Bilget Güven
Bilget Güven, Ebru
Güven, B.
Güven, E. B.
Güven, Ebru Bilget
Güven,E.B.
EBRU BILGET GÜVEN
Güven, E.
Ebru Bilget, Guven
Güven E.
GÜVEN, Ebru Bilget
Guven, Ebru Bilget
G., Ebru Bilget
Ebru Bilget GÜVEN
Guven,E.B.
GÜVEN, EBRU BILGET
Güven, EBRU BILGET
E. B. Güven
Guven,Ebru Bilget
G.,Ebru Bilget
Ebru Bilget Güven
Bilget Güven, Ebru
Güven, B.
Job Title
Dr. Öğr. Üyesi
Email Address
ebru.bguven@khas.edu.tr
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output
5
Articles
3
Citation Count
3
Supervised Theses
0
5 results
Scholarly Output Search Results
Now showing 1 - 5 of 5
Article Citation Count: 3A new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation(Nature Portfolio, 2022) Kahraman, Deniz Cansen; Guven, Ebru Bilget; Aytac, Peri S.; Aykut, Gamze; Tozkoparan, Birsen; Atalay, Rengul CetinHepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and resistant to both conventional and targeted chemotherapy. Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to decrease the incidence and mortality of different types of cancers. Here, we investigated the cellular bioactivities of a series of triazolothiadiazine derivatives on HCC, which have been previously reported as potent analgesic/anti-inflammatory compounds. From the initially tested 32 triazolothiadiazine NSAID derivatives, 3 compounds were selected based on their IC50 values for further molecular assays on 9 different HCC cell lines. 7b, which was the most potent compound, induced G2/M phase cell cycle arrest and apoptosis in HCC cells. Cell death was due to oxidative stress-induced JNK protein activation, which involved the dynamic involvement of ASK1, MKK7, and c-Jun proteins. Moreover, 7b treated nude mice had a significantly decreased tumor volume and prolonged disease-free survival. 7b also inhibited the migration of HCC cells and enrichment of liver cancer stem cells (LCSCs) alone or in combination with sorafenib. With its ability to act on proliferation, stemness and the migration of HCC cells, 7b can be considered for the therapeutics of HCC, which has an increased incidence rate of similar to 3% annually.Article Citation Count: 3Design, Synthesis and in Vitro Cytotoxic Activity of New 6,9-Disubstituted Purine Analogues(Slovensko Kemijsko Drustvo, 2020) Kuçükdumlu, Aslıgül; Tunçbilek, Meral; Bilget Güven, Ebru; Atalay, Rengül ÇetinA series of new 6,9-disubstituted purine analogs with 4-substituted piperazine at C-6 and 4-substituted benzyl at N-9 were designed and synthesized in four steps. All synthesized compounds (7-26) were screened initially for their in vitro anticancer activity on Huh7 liver, HCT116 colon and MCF7 breast carcinoma cell lines. Cytotoxic bioactivity studies revealed that all compounds screened, with compound 19 being the exception, were found to have promising cytotoxic activities at IC50 range of 0.05-21.8 mu M against cancer cells Huh7, HCT116 and MCF7. Among the prepared purine analogs, two of them (12 and 22) exhibited excellent cytotoxic activities, with IC50 0.08-0.13 mu M, on Huh7 cells comparable to camptothecin (CPT) and better than cladribine, fludarabine and 5-FU. Afterwards, the evaluation of cytotoxicity of the most potent purine analogs was screened against further hepatocellular cancer (HCC) cell lines. The 6-(4-(4-trifluoromethylphenyl)piperazine (12) and 6-(4-(3,4-dichlorophenyl)piperazine analogs (25) displayed a significant IC50 values (IC50 < 0.1-0.13 mu M) comparable to CPT and better cytotoxic bioactivity when compared with 5-FU, cladribine and fludarabine on HCC cells (Huh7 and HepG2).Article Citation Count: 0Development of an Enzyme Immunoassay for the Determination of Testosterone(2003) Güven, B.; Özsar, S.; Maraşli, N.; Maraşli, Ş.; Özcan, A.In this study, a double antibody enzyme immunoassay for the direct determination of testosterone in plasma was developed. Testosterone 3-O-CMO was conjugated with horseradish peroxidase by the mixed anhydride method, and the conjugate purified by column chromatography (sephadex G-25). Testosterone antibody was obtained by immunization of rabbits against Testosterone-3-O-CMO-BSA. Cross reactions of the antiserum against some steroids were found to be <0.01%. The detection limit of the assay was 2.5 pg/well and the working range of the standard curve was 0-20 ng/ml (0-200 pg/well). The recovery was found to be 98.8% after the addition of known amounts of testosterone to plasma samples. The inter-assay coefficient of variation was 12.6%. The described EIA offers a very economical alternative for the routine estimation of testosterone levels. Only minimal laboratory equipment is required and therefore the assay should be especially useful for research in animal science.Conference Object Citation Count: 0A New Thiadiazine Derivative Induces Oxidative Stress Dependent Cell Death in Hepatocellular Carcinoma Stem Cells(Wiley, 2019) Kahraman, Deniz Cansen; Bilget Güven, Ebru; Aytaç, Peri; Tozkoparan, Birsen; Çetin Atalay, Rengül[Abstract Not Available]Conference Object Citation Count: 0A New Thiadiazine Derivative Induces Oxidative Stress Dependent Jnk Pathway Activation and Cell Death in Hepatocellular Carcinoma(Amer Assoc Cancer Research,, 2019) Kahraman, Deniz Cansen; Bilget Güven, Ebru; Tozkoparan, Birsen; Çetin Atalay, Rengül[Abstract Not Available]
