Apolipoprotein B Gene Variants Are Involved in the Determination of Blood Glucose and Lipid Levels in Patients With Non-Insulin Dependent Diabetes Mellitus

dc.contributor.authorDuman, Belgin Süsleyici
dc.contributor.authorÖztürk, Melek
dc.contributor.authorYilmazer, Selma
dc.contributor.authorÇağatay, Penbe
dc.contributor.authorHatemi, Hüsrev
dc.date.accessioned2019-06-27T08:06:48Z
dc.date.available2019-06-27T08:06:48Z
dc.date.issued2006
dc.description.abstractWe have examined the frequency of the EcoRI XbaI and MspI RFLPs of the apolipoprotein B (apo 13) gene in I 10 type 2 diabetic patients and 9 1 healthy control subjects in order to ascertain whether variation in this gene may influence the development of non-insulin dependent diabetes mellitus (type 2 diabetes). Serum lipids including total-cholesterol (T-Chol) triacylglycerol (TAG) apolipoprotein E (apo E) apolipoprotein Al (apo Al) apolipoprotein B and lipoprotein (a) (Lp(a)) were analysed. Genomic DNA was extracted and the apo B polymorphic regions amplified by the polymerase chain reaction. Regions carrying EcoRI XbaI and MspI restriction sites present in the apo B gene were amplified and digested separately by the respective enzymes. No significant difference for genotypic frequencies was observed for the EcoRI XbaI and MspI restriction sites in type 2 diabetic patients as compared to controls. Type 2 diabetic patients and controls with EcoRI +/+ and XbaI +/+ genotypes had higher apo E levels. The MspI +/+ genotype is more frequent in the patient and control groups With elevated T-Chol. Furthermore the EcoRI -/- XbaI -/- and MspI +/+ genotypes were found to be significantly more frequent in type 2 diabetic patients with higher blood glucose levels. This study identifies the apo B gene polymorphisms in modulating plasma lipid/lipoprotein and glucose levels in patients with type 2 diabetes. Copyright 0 2005 John Wiley & Sons Ltd.en_US]
dc.identifier.citation7
dc.identifier.doi10.1027/cbf.1218en_US
dc.identifier.endpage267
dc.identifier.issn0263-6484en_US
dc.identifier.issn1099-0844en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue3
dc.identifier.pmid16634094en_US
dc.identifier.scopus2-s2.0-33646790855en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage261en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/1231
dc.identifier.urihttps://doi.org/10.1002/cbf.1218
dc.identifier.volume24en_US
dc.identifier.wosWOS:000237872600010en_US
dc.identifier.wosqualityQ3
dc.institutionauthorÖztürk, Meleken_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-insulin dependent diabetes mellitusen_US
dc.subjectApolipoprotein Ben_US
dc.subjectPolymorphismen_US
dc.titleApolipoprotein B Gene Variants Are Involved in the Determination of Blood Glucose and Lipid Levels in Patients With Non-Insulin Dependent Diabetes Mellitusen_US
dc.typeArticleen_US
dspace.entity.typePublication

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