The involvement of nitric oxide in the analgesic effects of ketamine

dc.contributor.authorBulutcu, Füsun S.
dc.contributor.authorDoğrul, Ahmet
dc.contributor.authorGüç, M. Oğuz
dc.date.accessioned2019-06-27T08:01:01Z
dc.date.available2019-06-27T08:01:01Z
dc.date.issued2002
dc.description.abstractWe investigated the contribution of NO-cyclic GMP (cGMP) pathway to the antinociceptive effects of ketamine in mice by using the nitric oxide synthase inhibitor nitro(g)-L-arginine methyl ester (L-NAME). Intraperitoneal (i.p.) (1 5 or 10 mg/kg) or intrathecal (i.th.) (10 30 or 60 mug/mouse) administration of ketamine produced dose-dependent antinociceptive effects in the acetic acid-induced writhing and formalin tests but not in the tail-flick nor in hot-plate tests. pretreatment of mice with L-NAME (10 mg/kg i.p.) which produced no antinociception on its own significantly inhibited the antinociceptive effect of ketamine (1 5 or 10 mg/kg i.p.). However L-NAME (30 mug/mouse) was given intrathecally it neither modified the antinociceptive effect of i.th. ketamine (10 3 0 or 60 mug/mouse) nor did it produce an antinociceptive effect alone. These data suggest that the activation of the NO-cGMP pathway probably at the supraspinal level but not spinal level contributes to the antinociceptive effects of ketamine. (C) 2002 Published by Elsevier Science Inc.en_US]
dc.identifier.citation33
dc.identifier.doi10.1016/S0024-3205(02)01765-4en_US
dc.identifier.endpage853
dc.identifier.issn0024-3205en_US
dc.identifier.issn0024-3205
dc.identifier.issue7
dc.identifier.pmid12074943en_US
dc.identifier.scopus2-s2.0-0037025040en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage841en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/212
dc.identifier.urihttps://doi.org/10.1016/S0024-3205(02)01765-4
dc.identifier.volume71en_US
dc.identifier.wosWOS:000177121100012en_US
dc.identifier.wosqualityQ1
dc.institutionauthorBulutçu, Füsun S.en_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.journalLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKetamineen_US
dc.subjectNitric oxideen_US
dc.subjectAnalgesiaen_US
dc.subjectNMDA receptorsen_US
dc.subjectAnaestheticsen_US
dc.subjectL-N-G nitro arginine methylester (L-NAME)en_US
dc.subjectFormalinen_US
dc.subjectWrithingen_US
dc.subjectPainen_US
dc.subjectDissociative anesthesiaen_US
dc.titleThe involvement of nitric oxide in the analgesic effects of ketamineen_US
dc.typeArticleen_US
dspace.entity.typePublication

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