The effects of prolactin on the immune system, its relationship with the severity of COVID-19, and its potential immunomodulatory therapeutic effect

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dc.contributor.authorRasmi, Yousef
dc.contributor.authorJalali, Ladan
dc.contributor.authorKhalid, Saliha
dc.contributor.authorShokati, Ameneh
dc.contributor.authorTyagi, Poonam
dc.contributor.authorOzturk, Alpaslan
dc.contributor.authorNasimfar, Amir
dc.date.accessioned2023-10-19T15:11:32Z
dc.date.available2023-10-19T15:11:32Z
dc.date.issued2023
dc.department-temp[Rasmi, Yousef; Jalali, Ladan] Urmia Univ Med Sci, Fac Med, Dept Biochem, Orumiyeh, Iran; [Khalid, Saliha] Kadir Has Univ, Sch Engn & Nat Sci, Dept Bioinformat & Genet, Cibali Campus Fatih, TR-34083 Istanbul, Turkiye; [Shokati, Ameneh] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Appl Cell Sci, Tehran, Iran; [Shokati, Ameneh] Univ Tehran Med Sci, Neurosci Inst, Multiple Sclerosis Res Ctr, Tehran, Iran; [Tyagi, Poonam] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Riyadh, Saudi Arabia; [Ozturk, Alpaslan] Hlth Sci Univ, Ankara Diskapi Yildirim Beyazit Training & Res Hos, Dept Med Biochem, Ankara, Turkiye; [Nasimfar, Amir] Urmia Univ Med Sci, Fac Med, Dept Pediat, Orumiyeh, Iran; [Jalali, Ladan] Urmia Univ Med Sci, Sch Med, Dept Biochem, Orumiyeh, Iranen_US
dc.description.abstractProlactin (PRL) is an endocrine hormone secreted by the anterior pituitary gland that has a variety of physiological effects, including milk production, immune system regulation, and anti-inflammatory effects. Elevated levels of PRL have been found in several viral infections, including 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), a viral pathogen that has recently spread worldwide. PRL production is increased in SARS-CoV2 infection. While PRL can trigger the production of proinflammatory cytokines, it also has several anti-inflammatory effects that can reduce hyperinflammation. The exact mechanism of PRL's contribution to the severity of COVID-19 is unknown. The purpose of this review is to discuss the interaction between PRL and SARS-CoV2 infection and its possible association with the severity of COVID-19.en_US
dc.identifier.citation4
dc.identifier.doi10.1016/j.cyto.2023.156253en_US
dc.identifier.issn1043-4666
dc.identifier.issn1096-0023
dc.identifier.pmid37320963en_US
dc.identifier.scopus2-s2.0-85162171729en_US
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2023.156253
dc.identifier.urihttps://hdl.handle.net/20.500.12469/5061
dc.identifier.volume169en_US
dc.identifier.wosWOS:001054021200001en_US
dc.identifier.wosqualityQ3
dc.khas20231019-WoSen_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofCytokineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNecrosis-Factor-AlphaEn_Us
dc.subjectActivated MacrophagesEn_Us
dc.subjectSignal-TransductionEn_Us
dc.subjectGrowth-HormoneEn_Us
dc.subjectC-JunEn_Us
dc.subjectExpressionEn_Us
dc.subjectCellEn_Us
dc.subjectReceptorEn_Us
dc.subjectMechanismsEn_Us
dc.subjectReleaseEn_Us
dc.subjectNecrosis-Factor-Alpha
dc.subjectActivated Macrophages
dc.subjectSignal-Transduction
dc.subjectGrowth-Hormone
dc.subjectC-Jun
dc.subjectExpression
dc.subjectProlactinen_US
dc.subjectCell
dc.subjectSARS-CoV-2en_US
dc.subjectReceptor
dc.subjectSeverityen_US
dc.subjectMechanisms
dc.subjectCOVID-19en_US
dc.subjectRelease
dc.subjectImmunomodulatory effectsen_US
dc.titleThe effects of prolactin on the immune system, its relationship with the severity of COVID-19, and its potential immunomodulatory therapeutic effecten_US
dc.typeArticleen_US
dspace.entity.typePublication

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