Genetic Variations of the Apolipoprotein B Gene in Turkish Patients With Coronary Artery Disease

dc.contributor.author Duman, Belgin Süsleyici
dc.contributor.author Türkoğlu, Çavlan
dc.contributor.author Akpınar, Belhhan
dc.contributor.author Güden, Mustafa
dc.contributor.author Vertii, Anastassia
dc.contributor.author Çağatay, Penbe
dc.contributor.author Günay, Demet
dc.contributor.author Büyükdevrim, Ahmet Sevim
dc.date.accessioned 2019-06-27T08:00:51Z
dc.date.available 2019-06-27T08:00:51Z
dc.date.issued 2005
dc.description.abstract Background: The results of studies that clarify the association of genetic markers at the apolipoprotein B (apo B) gene (EcoRI and XbaI polymorphisms) with coronary artery disease (CAD) are not consistent and suggest that the effect is context dependent (dependent on ethnicity and sex). The present study represents the first investigation of the apo B gene polymorphisms in Turkish patients with CAD and their influence on lipid levels. Aim: The study investigated the association of apo B gene EcoRI and XbaI polymorphisms with CAD and with variation in lipid levels (total cholesterol (T-Chol) high-density lipoprotein cholesterol (HDL-Chol) low-density lipoprotein cholesterol (LDL-Chol) and triacylglycerol (TAG)). Subjects and methods: The study group was composed of 150 individuals with angiographically documented CAD and 100 angiographically proven to be healthy controls. PCR-RFLP was used to determine the DNA polymorphisms of the apo B gene. Results: The frequencies of apo B genotypes detected with EcoRI (AA AG GG) and XbaI (CC CT T-F) did not differ significantly between case and control subjects. A significant association between EcoRI genotypes and T-Chol (p <= 0.05) and LDL-Chol (p <= 0.001) was observed only in CAD patients. Patients with the AA genotype had higher levels of serum T-Chol and LDL-Chol compared with AG. With logistic regression analysis the XbaI TT genotype was found to be associated with CAD prevention. However no significant differences in lipid variables were determined for the XbaI polymorphisms in the patients with CAD. Conclusions: Apo B EcoRI genotypes were not found as risk factors for CAD whereas XbaI TT genotype was detected to prevent against CAD in our study group. en_US]
dc.identifier.citationcount 12
dc.identifier.doi 10.1080/03014460500228626 en_US
dc.identifier.endpage 629
dc.identifier.issn 0301-4460 en_US
dc.identifier.issn 1464-5033 en_US
dc.identifier.issn 0301-4460
dc.identifier.issn 1464-5033
dc.identifier.issue 5
dc.identifier.pmid 16316917 en_US
dc.identifier.scopus 2-s2.0-27844531701 en_US
dc.identifier.scopusquality Q2
dc.identifier.startpage 620 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/120
dc.identifier.uri https://doi.org/10.1080/03014460500228626
dc.identifier.volume 32 en_US
dc.identifier.wos WOS:000233411200006 en_US
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Taylor & Francis Ltd en_US
dc.relation.journal Annals of Human Biology en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 15
dc.subject Polymorphism en_US
dc.subject Lipoproteins en_US
dc.subject Coronary artery disease en_US
dc.title Genetic Variations of the Apolipoprotein B Gene in Turkish Patients With Coronary Artery Disease en_US
dc.type Article en_US
dc.wos.citedbyCount 14
dspace.entity.type Publication

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