Biclustering Expression Data Based on Expanding Localized Substructures

dc.contributor.authorErten, Cesim
dc.contributor.authorSözdinler, Melih
dc.date.accessioned2019-06-27T08:05:47Z
dc.date.available2019-06-27T08:05:47Z
dc.date.issued2009
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümüen_US
dc.description.abstractBiclustering gene expression data is the problem of extracting submatrices of genes and conditions exhibiting significant correlation across both the rows and the columns of a data matrix of expression values. We provide a method LEB (Localize-and-Extract Biclusters) which reduces the search space into local neighborhoods within the matrix by first localizing correlated structures. The localization procedure takes its roots from effective use of graph-theoretical methods applied to problems exhibiting a similar structure to that of biclustering. Once interesting structures are localized the search space reduces to small neighborhoods and the biclusters are extracted from these localities. We evaluate the effectiveness of our method with extensive experiments both using artificial and real datasets.en_US]
dc.identifier.citation5
dc.identifier.doi10.1007/978-3-642-00727-9_22en_US
dc.identifier.endpage+
dc.identifier.isbn978-3-642-00726-2
dc.identifier.issn0302-9743en_US
dc.identifier.issn1611-3349en_US
dc.identifier.issn0302-9743
dc.identifier.issn1611-3349
dc.identifier.scopus2-s2.0-68249117368en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage224en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/1116
dc.identifier.urihttps://doi.org/10.1007/978-3-642-00727-9_22
dc.identifier.volume5462en_US
dc.identifier.wosWOS:000265785800022en_US
dc.institutionauthorErten, Cesimen_US
dc.institutionauthorErten, Cesim
dc.language.isoenen_US
dc.publisherSpringer-Verlag Berlinen_US
dc.relation.journalInternational Conference on Bioinformatics and Computational Biologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleBiclustering Expression Data Based on Expanding Localized Substructuresen_US
dc.typeConference Objecten_US
dspace.entity.typePublication
relation.isAuthorOfPublicationba94d962-58f9-4c10-bdc8-667be0ec3b67
relation.isAuthorOfPublication.latestForDiscoveryba94d962-58f9-4c10-bdc8-667be0ec3b67

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