Dna Polymorphism of Pvu Ii Site in the Lipoprotein Lipase Gene in Patients With Non-Insulin Dependent Diabetes Mellitus

dc.contributor.author Duman, Belgin Süsleyici
dc.contributor.author Öztürk, Melek
dc.contributor.author Yilmazer, Selma
dc.contributor.author Çağatay, Penbe
dc.contributor.author Hatemi, Hüsrev
dc.date.accessioned 2019-06-27T08:00:51Z
dc.date.available 2019-06-27T08:00:51Z
dc.date.issued 2005
dc.description.abstract We studied the effect of variation at the lipoprotein lipase (LPL) gene locus on the susceptibility of individuals with non-insulin dependent diabetes mellitus (NIDDM) in a population of 110 NIDDM patients and 91 controls. Our objective was to study the relationship between the LPL-Pvu II polymorphism and NIDDM and lipid metabolism. PCR-RFLP was used to determine the DNA polymorphism of the sixth intron of the LPL gene. The frequencies of the genotypes in case and control groups were 29.1 and 30.8% for P+/P+ en_US]
dc.description.abstract 45.5 and 36.3% for P+/P- en_US]
dc.description.abstract 25.5 and 33% for P-/P- respectively. There was no significant difference in frequencies of genotypes between the two groups. Logistic regression analysis revealed that triacylglycerol (TAG) and apolipoprotein E levels were associated with NIDDM whereas Pvu II genotypes were not found as independent risk factors for the disease. Overall this study demonstrates the role of the Pvu II polymorphism in the LPL gene in modulating plasma lipid/lipoprotein levels in patients with NIDDM. Copyright (c) 2004 John Wiley & Sons Ltd. en_US]
dc.identifier.citationcount 2
dc.identifier.doi 10.1027/cbf.1162 en_US
dc.identifier.endpage 404
dc.identifier.issn 0263-6484 en_US
dc.identifier.issn 1099-0844 en_US
dc.identifier.issn 0263-6484
dc.identifier.issn 1099-0844
dc.identifier.issue 6
dc.identifier.pmid 15543643 en_US
dc.identifier.scopus 2-s2.0-27844474643 en_US
dc.identifier.scopusquality Q2
dc.identifier.startpage 399 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/116
dc.identifier.uri https://doi.org/10.1027/cbf.1162
dc.identifier.volume 23 en_US
dc.identifier.wos WOS:000233352300004 en_US
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.relation.journal Cell Biochemistry and Function en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 3
dc.subject NIDDM en_US
dc.subject Lipoprotein lipase en_US
dc.subject Polymorphism en_US
dc.subject Pvu II en_US
dc.subject Lipoprotein en_US
dc.title Dna Polymorphism of Pvu Ii Site in the Lipoprotein Lipase Gene in Patients With Non-Insulin Dependent Diabetes Mellitus en_US
dc.type Article en_US
dc.wos.citedbyCount 2
dspace.entity.type Publication

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