Lipoprotein lipase gene polymorphism and lipid profile in coronary artery disease
Abstract
Context.-Lipoprotein lipase (LPL) plays a central role in lipid metabolism hydrolyzing triglyceride in chylomicrons and very-low-density lipoproteins. The PvuII polymorphic variant of LPL gene is common and might affect risk of coronary artery disease (CAD). Objective.-Our aim was to determine whether LPL-PvuII polymorphism can be considered to be an independent risk factor or a predictor for CAD in Turkish subjects. Design.-We used polymerase chain reaction and restriction enzyme digestion to determine the distribution of the previously described C-->T transition that causes a PvuII polymorphism in intron 6 among healthy blood donors of Turkish origin and among angiographically confirmed CAD patients with comparable ethnic backgrounds. Results.-For the PvuII genotypes within the CAD group (n = 80) the +/- genotype was found in 39 individuals (48.8%) whereas 25 (31.3%) carried the +/+ genotype and 14 (17.5%) carried the -/- genotype. Within the control group (n = 49) the -/- genotype was found in 19 individuals (38.8%) 16 (32.7%) carried the +/- genotype and 14 (28.6%) carried the +/+ genotype. The genotype frequency distribution was significantly different (P = .049) in the CAD and control study groups. The most frequent genotype among CAD patients was +/- this genotype was more frequent in patients than in control subjects. However the -/- genotype was more prevalent in the control group. Lipoprotein lipase-PvuII polymorphism was found to be associated with fasting total cholesterol and low-density lipoprotein cholesterol levels. The +/+ genotype was found to have higher levels of total cholesterol and low-density lipoprotein cholesterol in both the CAD and control groups. Conclusion.-There was a difference in the distribution of LPL-PvuII genotypes between the healthy subjects and the patients with CAD. Lipoprotein lipase-PvuII polymorphisms were not detected as independent risk factors for CAD in this study group but had associations with lipid levels.
Source
Archives of Pathology & Laboratory MedicineIssue
8Volume
128Pages
869-874URI
https://hdl.handle.net/20.500.12469/151https://www.archivesofpathology.org/doi/full/10.1043/1543-2165(2004)128%3C869:LLGPAL%3E2.0.CO;2
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- Araştırma Çıktıları / PubMed [194]
- Araştırma Çıktıları / Scopus [1565]
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