Vitamin D receptor alleles bone mineral density and turnover in postmenopausal osteoporotic and healthy women
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Date
2004
Authors
Duman, Belgin Süsleyici
Tanakol, Refik
Erensoy, Nevin
Öztürk, Melek
Yılmazer, Selma
Journal Title
Journal ISSN
Volume Title
Publisher
Karger
Abstract
Objective: Vitamin D receptor (VDR) gene polymorphisms and bone metabolic markers were investigated as potential genetic markers for osteoporosis in postmenopausal Turkish women. The relationship between their VDR gene polymorphisms and bone states was determined. Materials and Methods: Restriction fragment length polymorphisms at the VDR gene locus (i.e. for BsmI ApaI and TaqI) was investigated in 75 postmenopausal osteoporotic (53.16+/-1.31 years) and 66 healthy (52.62+/-1.69 years) Turkish women and the genotypes were related to bone mineral density (BMD) at femoral neck (FN) lumbar spine (L1-4) trochanter Ward's triangle (Ward's) and metabolic parameters of bone turnover. Results: In osteoporotic women TaqI genotype-related differences of the VDR gene were found to be significant at all BMD sites
TT genotype had higher L1-4 BMD values than Tt and tt (p<0.05)
tt genotype had significantly lower BMD at FN (p<0.05) trochanter (p<0.01) and Ward's (p<0.05) compared to TT genotype. The tt genotype was found to be associated with higher (p<0.05) serum osteocalcin levels compared to Tt and TT genotypes in the osteoporotic women whereas no such association was found for the healthy women. Conclusion: Our data showed an association between VDR TaqI genotype and BMD at the FN L1-4 trochanter and Ward's triangle in nonobese postmenopausal osteoporotic women. Thus the VDR gene TaqI polymorphism modulates differences in BMD in the postmenopausal osteoporotic women. Copyright (C) 2004 S. Karger AG Basel.
TT genotype had higher L1-4 BMD values than Tt and tt (p<0.05)
tt genotype had significantly lower BMD at FN (p<0.05) trochanter (p<0.01) and Ward's (p<0.05) compared to TT genotype. The tt genotype was found to be associated with higher (p<0.05) serum osteocalcin levels compared to Tt and TT genotypes in the osteoporotic women whereas no such association was found for the healthy women. Conclusion: Our data showed an association between VDR TaqI genotype and BMD at the FN L1-4 trochanter and Ward's triangle in nonobese postmenopausal osteoporotic women. Thus the VDR gene TaqI polymorphism modulates differences in BMD in the postmenopausal osteoporotic women. Copyright (C) 2004 S. Karger AG Basel.
Description
Keywords
Bone mineral density, Vitamin D receptor gene polymorphism, Osteoporosis, Menopause
Turkish CoHE Thesis Center URL
Citation
33
WoS Q
N/A
Scopus Q
Q2
Source
Volume
13
Issue
5
Start Page
260
End Page
266